Grants
```r
merged_grant_df <- dccvalidator::get_synapse_table(\syn21918972\, syn)
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```r
merged_grant_df %>%
select(-institutionAlias) %>%
# select(grantId, institutionId) %>%
separate_rows(institutionId, sep = ",") %>%
mutate_all(~ str_trim(.)) %>%
left_join(select(db_institution_df, institutionId = id, institutionAlias = displayName),
by = "institutionId") %>%
group_by_at(vars(-one_of(c("institutionId", "institutionAlias")))) %>%
summarize_all(~ str_c(., collapse = ", ")) %>%
ungroup() %>%
mutate(institutionAlias = map_chr(institutionAlias, .delim_str_to_json)) %>%
update_synapse_table("syn21918972", ., syn, syntab)
<synapseclient.table.CsvFileTable>
merged_grant_df %>%
select(grantId, institutionId) %>%
separate_rows(institutionId, sep = ",") %>%
mutate_all(str_trim) %>%
distinct() %>%
I %>%
update_synapse_table("syn21905912", ., syn, syntab)
<synapseclient.table.CsvFileTable>
db_institution_df <- dccvalidator::get_synapse_table("syn21905891", syn)
merged_grant_cleaned <- merged_grant_df %>%
separate_rows(institutionId, institution, sep = "\\|") %>%
mutate_all(str_trim) %>%
distinct() %>%
arrange(institution) %>%
mutate(institutionId = case_when(
institution == "University of Pennsylvania" ~ "syn21905883",
institution == "University of Virginia" ~ "syn21905886",
institution == "University of Colorado Denver" ~ "",
institution == "University of Delaware" ~ "",
institution == "Pacific Northwest National Laboratory" ~ "",
institution == "Massachusetts Institute of Technology" ~ "syn21905863",
institution == "The Hebrew University of Jerusalem" ~ "",
TRUE ~ institutionId
)) %>%
mutate(institution = str_replace(institution, "^The ", "")) %>%
# filter(institutionId == "") %>%
left_join(select(db_institution_df, id, institution = fullName), by = "institution") %>%
mutate(institutionId = ifelse(institutionId == "", id, institutionId)) %>%
select(-id) %>%
distinct() %>%
group_by_at(vars(-contains("institution"))) %>%
summarize(
institutionId = str_c(unique(institutionId), collapse = ", "),
institution = str_c(unique(institution), collapse = " | ")
) %>%
ungroup() %>%
mutate_all(~ ifelse(str_detect(., "Not Applicable"), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '"Not Applicable"'), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., "^NA$"), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '\\["NA"\\]'), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '"NA"'), NA, .)) %>%
I
merged_grant_cleaned
```r
merged_grant_syntable <- update_synapse_table(\syn21918972\, merged_grant_cleaned, syn, syntab)
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## Projects
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```r
```r
merged_project_df <- dccvalidator::get_synapse_table(\syn21868602\, syn)
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```r
```r
merged_project_cleaned <- merged_project_df %>%
mutate(theme = str_replace(theme, \Tumor Evolution\, \Evolution\)) %>%
mutate(theme = str_replace(theme, \metastasis\, \Metastasis\)) %>%
mutate(theme = str_replace(theme, \drug resistance/sensitivity\, \Drug Resistance/Sensitivity\)) %>%
mutate(theme = str_replace(theme, \microenvironment\, \Microenvironment\)) %>%
mutate_all(~ ifelse(str_detect(., \Not Applicable\), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '\Not Applicable\'), \\, .)) %>%
mutate_all(~ ifelse(str_detect(., \^NA$\), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '\\[\NA\\\]'), \[]\, .)) %>%
mutate_all(~ ifelse(str_detect(., '\NA\'), \\, .)) %>%
# filter(projectId == \syn21645193\) %>%
# update_synapse_table(\syn21930566\, ., syn, syntab) %>%
I
merged_project_cleaned
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```r
```r
merged_project_syntable <- update_synapse_table(\syn21868602\, merged_project_cleaned, syn, syntab)
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## Tools
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```r
```r
merged_tool_df <- dccvalidator::get_synapse_table(\syn21930566\, syn)
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```r
```r
merged_tool_cleaned <- merged_tool_df %>%
mutate(theme = str_replace(theme, \Tumor Evolution\, \Evolution\)) %>%
mutate_all(~ ifelse(str_detect(., \Not Applicable\), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '\Not Applicable\'), \\, .)) %>%
mutate_all(~ ifelse(str_detect(., \^NA$\), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '\\[\NA\\\]'), \[]\, .)) %>%
mutate_all(~ ifelse(str_detect(., '\NA\'), \\, .)) %>%
mutate(homepageUrl = ifelse(is.na(homepageUrl), \\, homepageUrl)) %>%
mutate(toolType = ifelse(is.na(toolType), \\, toolType)) %>%
mutate(publicationId = ifelse(is.na(publicationId), \\, publicationId)) %>%
mutate(publicationTitle = ifelse(is.na(publicationTitle), \\, publicationTitle)) %>%
mutate(publication = ifelse(is.na(publication), \\, publication))
merged_tool_cleaned
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```r
```r
merged_tool_syntable <- update_synapse_table(\syn21930566\, merged_tool_cleaned, syn, syntab)
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## Datasets
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```r
merged_dataset_df <- dccvalidator::get_synapse_table("syn21897968", syn)
```r
merged_dataset_cleaned <- merged_dataset_df %>%
mutate(theme = str_replace(theme, \Tumor Evolution\, \Evolution\)) %>%
mutate(theme = str_replace(theme, \metastasis\, \Metastasis\)) %>%
mutate(theme = str_replace(theme, \drug resistance/sensitivity\, \Drug Resistance/Sensitivity\)) %>%
mutate(theme = str_replace(theme, \microenvironment\, \Microenvironment\)) %>%
mutate(assay = str_replace(assay, \Whoe\, \Whole\)) %>%
mutate_all(~ ifelse(str_detect(., \Not Applicable\), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '\Not Applicable\'), \\, .)) %>%
mutate_all(~ ifelse(str_detect(., \^NA$\), NA, .)) %>%
mutate_all(~ ifelse(str_detect(., '\\[\NA\\\]'), \[]\, .)) %>%
mutate_all(~ ifelse(str_detect(., '\NA\'), \\, .)) %>%
mutate(tumorType = ifelse(is.na(tumorType), \\, tumorType)) %>%
# filter(datasetId == \syn21645193\) %>%
# update_synapse_table(\syn21930566\, ., syn, syntab) %>%
I
merged_dataset_cleaned
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{"columns":[{"label":[""],"name":["_rn_"],"type":[""],"align":["left"]},{"label":["datasetId"],"name":[1],"type":["chr"],"align":["left"]},{"label":["datasetName"],"name":[2],"type":["chr"],"align":["left"]},{"label":["datasetAlias"],"name":[3],"type":["chr"],"align":["left"]},{"label":["description"],"name":[4],"type":["chr"],"align":["left"]},{"label":["overallDesign"],"name":[5],"type":["chr"],"align":["left"]},{"label":["assay"],"name":[6],"type":["chr"],"align":["left"]},{"label":["species"],"name":[7],"type":["chr"],"align":["left"]},{"label":["tumorType"],"name":[8],"type":["chr"],"align":["left"]},{"label":["themeId"],"name":[9],"type":["chr"],"align":["left"]},{"label":["theme"],"name":[10],"type":["chr"],"align":["left"]},{"label":["consortiumId"],"name":[11],"type":["chr"],"align":["left"]},{"label":["consortium"],"name":[12],"type":["chr"],"align":["left"]},{"label":["grantId"],"name":[13],"type":["chr"],"align":["left"]},{"label":["grant"],"name":[14],"type":["chr"],"align":["left"]},{"label":["grantName"],"name":[15],"type":["chr"],"align":["left"]},{"label":["publicationId"],"name":[16],"type":["chr"],"align":["left"]},{"label":["publicationTitle"],"name":[17],"type":["chr"],"align":["left"]},{"label":["publication"],"name":[18],"type":["chr"],"align":["left"]},{"label":["externalLink"],"name":[19],"type":["chr"],"align":["left"]}],"data":[{"1":"syn21789710","2":"Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state","3":"PRJNA252579","4":"mRNA-seq and ribosome profiling of neural stem cells overexpressing or knocked out for Musashi RNA-binding proteins","5":"Study of the global effects of Musashi (Msi) proteins on the transcriptome of embryonic neural stem cells. Neural stem cells were derived from brains of E12.5 or E13.5 embryos engineered to have inducible Msi1 or Msi2 genes, or from embryos with double floxed alleles of Msi1 and Msi2 carrying a Tamoxifen-induclble Cre (CreER). The overexpression mice were made using the Flp-in system (OpenBioSystems), where a cDNA of interest (in this case Msi1 or Msi2) is knocked into the Collagen (Col1A1) locus. The expression of the cDNA of interest is driven by m2rTTA that is knocked into the Rosa26 locus (R26). KH2 describes a strain containing the R26-m2rTTA but lacking Msi1 or Msi2 cDNA. MSI1 describes a strain containing R26-m2rTTA and Msi1 cDNA in Col1A1. MSI2 describes a strain containing R26-m2rTTA and Msi2 cDNA in Col1A1. C1 describes a strain lacking the CreER allele but containing double floxed alleles of Msi1/Msi2 (used as Tamoxifen control). C4 describes a strain carrying the CreER allele and double floxed alleles of Msi1/Msi2.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630079, syn21630075","10":"[\"Metastasis\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775689","14":"[\"CA184897\"]","15":"Dynamics of Gene and Isoform Regulation during EMT and tumor progression","16":"syn21645611","17":"Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state","18":"[Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state(PMID:25380226)](https://www.ncbi.nlm.nih.gov/pubmed/?term=25380226)","19":"[GEO:GSE58423](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58423), [SRA:SRP043153](https://www.ncbi.nlm.nih.gov/sra?term=SRP043153)","_rn_":"1"},{"1":"syn13858921","2":"Methylation disorder in CLL","3":"PRJNA253815","4":"We performed RRBS and WGBS on primary human chronic lymphocytic leukemia and normal healthy donor B cell samples Due to patient privacy concerns, the raw data is being made available via controlled access in dbGaP (http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000435.v1.p1).","5":"cross-sectional/longitudinal","6":"[\"Bisulfite Sequencing\"]","7":"[\"Human\"]","8":"[\"Chronic Lymphocytic Leukemia\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE58889](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE58889)","_rn_":"2"},{"1":"syn10846118","2":"Transcriptome analysis of isolated stormal cells and tumor epithelial cells in mouse lung cancer by RNA-Seq","3":"PRJNA256324","4":"We sequenced mRNA from individual stormal cells (Macrophages, Monocytes, and Neutrophils) and tumor epithelial cells from KrasG12dD; p53-/- murine lung cancer model and WT control mouse to compare gene expressio profiles of lung cancer stroma and tumor cells to their counterparts of WT lugns. The tumor was generated by injecting HKP1 lung cancer cell line, which was driven by KrasG12D activation and loss of p53, via tail vein. The cells were sorted by their specific surface markers at day 20-25 after orthortopic lung cancer formation.","5":"Examination of mRNA levels in individual stormal cells and tumor cells from tumor lungs compared to their counterparts from WT lungs","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Lung Non-Small Cell Carcinoma\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775595","14":"[\"CA188388\"]","15":"Modeling and targeting stroma-tumor crosstalk in non small cell lung cancer","16":"NA","17":"Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model","18":"[\"Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model(PMID: 25704820)\"](https://www.ncbi.nlm.nih.gov/pubmed/25704820)","19":"[GEO:GSE59831](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE59831)","_rn_":"3"},{"1":"syn21790604","2":"H3K27ac ChIP in Dicer KO/WT [ChIP-seq]","3":"PRJNA260117","4":"We performed ChIP-Seq of H3K27ac in duplicate in both WT and KO mesenchymal stem cells to evaluate global transcriptional changes between the new cells. We identified putative transcription factor binding sites using GEM v1.1 in K27ac data as well as in p MicroRNAs (miRNAs) are small non-coding RNAs that regulates development and disease but induce only moderate repression of directs mRNA targets, suggesting that they coordinate with other modes ofs cellular regulation to effect large changes in gene expression. Ins this work we decouple direct effects of global miRNA loss froms transcriptional changes downstream in a pair of isogenic murines fibroblast cell lines with and without Dicer expression. Wes demonstrate how effects on direct miRNA targets are amplified bys transcription machinery through the construction of a network models that identifies specific transcription factors that cause changes ins mRNA expression upon Dicer loss. Through transcription factors over-expression, we delineate miRNA-mediated transcriptional programss and identify miRNA-mediated coherent and incoherent feed-forwards loops, suggesting a functional role of the interaction between miRNAss and transcription factors. In total, our results indicate thats miRNAs tightly control transcription factors within a denses interconnected network to modulate gene expression.","5":"The experiment was designed to mimic the previously captured ChIP-Seq with two replicates in both WT and KO MSCs","6":"[\"ChIP-Seq\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630075","10":"[\"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9772917","14":"[\"CA184898\"]","15":"Embryonal Brain Tumor Networks","16":"syn21645595","17":"Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements","18":"[Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements(PMID:26748710)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26748710)","19":"[GEO:GSE61034](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE61034), [SRA:SRP046258](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP046258)","_rn_":"4"},{"1":"syn21790607","2":"Dicer WT/KO MSC RNA-Seq [total RNA]","3":"PRJNA260118","4":"RNA-Seq performed on Dicer KO and WT murine mesenchymal stem cells from total RNA MicroRNAs (miRNAs) are small non-coding RNAs that regulates development and disease but induce only moderate repression of directs mRNA targets, suggesting that they coordinate with other modes ofs cellular regulation to effect large changes in gene expression. Ins this work we decouple direct effects of global miRNA loss froms transcriptional changes downstream in a pair of isogenic murines fibroblast cell lines with and without Dicer expression. Wes demonstrate how effects on direct miRNA targets are amplified bys transcription machinery through the construction of a network models that identifies specific transcription factors that cause changes ins mRNA expression upon Dicer loss. Through transcription factors over-expression, we delineate miRNA-mediated transcriptional programss and identify miRNA-mediated coherent and incoherent feed-forwards loops, suggesting a functional role of the interaction between miRNAss and transcription factors. In total, our results indicate thats miRNAs tightly control transcription factors within a denses interconnected network to modulate gene expression.","5":"Total RNA was analyzed from adult mesenchymal stem cells (immortalized monoclonal lines of murine MSCs) with and without Dicer (WT: Dicer f/f, KO: Dicer -/-), as well as from WT cells transfected with an empty vector or a vector containing Tead4, Sox9 or Pbx3 transcripts.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630075","10":"[\"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9772917","14":"[\"CA184898\"]","15":"Embryonal Brain Tumor Networks","16":"syn21645595","17":"Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements","18":"[Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements(PMID:26748710)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26748710)","19":"[GEO:GSE61033](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE61033)","_rn_":"5"},{"1":"syn21811280","2":"Altering cancer transcriptomes using epigenomic inhibitors [RNA-Seq]","3":"PRJNA269148","4":"We have compared the genome-wide effects on the transcriptome after treatment with ICG-001 (the specific CBP inhibitor) versus C646, a compound that competes with acetyl-coA for the Lys-coA binding pocket of both CBP and p300. We found that both drugs cause large-scale changes in the transcriptome of HCT116 colon cancer cells and PANC1 pancreatic cancer cells, and reverse some tumor-specific changes in gene expression. Interestingly, although the epigenetic inhibitors affect cell cycle pathways in both the colon and pancreatic cancer cell lines, the WNT signaling pathway was affected only in the colon cancer cells. Notably, WNT target genes were similarly down-regulated after treatment of HCT116 with C646 as with ICG-001.","5":"To identify genes affected by direct targeting of a component of the transcriptional complex implicated in WNT regulation, we used siRNAs to knockdown TCF7L2 in PANC1 cells. Cells were treated with control siRNAs or siRNAs specific for TCF7L2 and RNA was analyzed by RNA-seq.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE63776](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63776), [SRA:SRP050497](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP050497)","_rn_":"6"},{"1":"syn21811256","2":"Altering cancer transcriptomes using epigenomic inhibitors [Illumina beadchip]","3":"PRJNA269947","4":"We have compared the genome-wide effects on the transcriptome after treatment with ICG-001 (the specific CBP inhibitor) versus C646, a compound that competes with acetyl-coA for the Lys-coA binding pocket of both CBP and p300. We found that both drugs cause large-scale changes in the transcriptome of HCT116 colon cancer cells and PANC1 pancreatic cancer cells, and reverse some tumor-specific changes in gene expression. Interestingly, although the epigenetic inhibitors affect cell cycle pathways in both the colon and pancreatic cancer cell lines, the WNT signaling pathway was affected only in the colon cancer cells. Notably, WNT target genes were similarly down-regulated after treatment of HCT116 with C646 as with ICG-001.","5":"Total RNA obtained from isolated HCT116 or PANC1 cell lines were treated with 10uM ICG-001, 10uM C646, or 0.05% DMSO and collected after 12 or 96 hours.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE64038](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE64038)","_rn_":"7"},{"1":"syn21789760","2":"Robust enumeration of cell subsets from tissue expression profiles (HGU133Plus2)","3":"PRJNA273241","4":"We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content, and closely related cell types. CIBERSORT should enable large-scale analysis of RNA specimens for cellular biomarkers and therapeutic targets (http://cibersort.stanford.edu).","5":"To evaluate the performance of CIBERSORT, RNA was extracted from the following primary human samples: (i) 14 disaggregated lymph node biopsies from patients with follicular lymphoma (FL), (ii) pre- and/or post-immunotherapy PBMC samples from 3 patients with extranodal marginal zone lymphoma (EMZL) or diffuse large B cell lymphoma (DLBCL), and (iii) B or T cells purified from the tonsils of 5 healthy normal controls.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630077, syn21630079, syn21630078","10":"[\"Tumor-Immune\", \"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315808","14":"[\"CA209971\"]","15":"Stanford University Center for Cancer Systems Biology","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE65135](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE65135)","_rn_":"8"},{"1":"syn21789789","2":"Robust enumeration of cell subsets from tissue expression profiles (HGU133A)","3":"PRJNA273242","4":"We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content, and closely related cell types. CIBERSORT should enable large-scale analysis of RNA specimens for cellular biomarkers and therapeutic targets (http://cibersort.stanford.edu).","5":"To evaluate the performance of CIBERSORT for enumerating Tregs, RNA was extracted from PBMC samples from 6 healthy normal controls and 1 follicular lymphoma (FL) patient. All PBMC samples were also interrogated by flow cytometry for FOXP3+ Tregs.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630077, syn21630079, syn21630078","10":"[\"Tumor-Immune\", \"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315808","14":"[\"CA209971\"]","15":"Stanford University Center for Cancer Systems Biology","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE65134](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE65134)","_rn_":"9"},{"1":"syn21789797","2":"Robust enumeration of cell subsets from tissue expression profiles (BeadChip)","3":"PRJNA273243","4":"We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with respect to noise, unknown mixture content, and closely related cell types. CIBERSORT should enable large-scale analysis of RNA specimens for cellular biomarkers and therapeutic targets (http://cibersort.stanford.edu).","5":"To evaluate the performance of CIBERSORT against flow cytometry, gene expression profiling was performed on a set of 20 PBMC samples comprised of adults of varying ages receiving influenza immunization (NCT01827462). These samples were analyzed by flow cytometry to enumerate several leukocyte subsets. Normalized gene expression data and accompanying flow cytometry data are available at the CIBERSORT website (http://cibersort.stanford.edu/download.php).","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630077, syn21630079, syn21630078","10":"[\"Tumor-Immune\", \"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315808","14":"[\"CA209971\"]","15":"Stanford University Center for Cancer Systems Biology","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE65133](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE65133)","_rn_":"10"},{"1":"syn21790630","2":"Profiling of soma and neurite transcriptomes","3":"PRJNA281008","4":"We report mRNA profiles of subcellularly localized transcriptomes (soma and neurite) of two mouse cell lines, N2A and CAD, as well as primary cortical neurons from E18.5 mice. We also performed this fractionation and sequencing after RNAi knockdown (cell lines) or in knockout mice (primary cortical neurons) of the RNA-binding proteins muscleblind 1 and 2 (Mbnl1 and Mbnl2).","5":"Fractionate neurons using porous transwell membranes. Isolate poly-A RNA.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630079, syn21630075","10":"[\"Metastasis\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775689","14":"[\"CA184897\"]","15":"Dynamics of Gene and Isoform Regulation during EMT and tumor progression","16":"syn21645610","17":"Distal Alternative Last Exons Localize mRNAs to Neural Projections","18":"[Distal Alternative Last Exons Localize mRNAs to Neural Projections(PMID:26907613)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26907613)","19":"[GEO:GSE67828](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67828)","_rn_":"11"},{"1":"syn21790715","2":"Activation of proto-oncogenes by disruption of chromosome neighborhoods [chIA-PET]","3":"PRJNA284250","4":"Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. Recurrent microdeletions frequently overlap neighborhood boundary sites in T-ALL genomes, and we demonstrate that site-specific perturbation of loop boundaries is sufficient to activate the respective proto-oncogenes in non-malignant cells. We found somatic genomic rearrangements affecting loop boundaries in many cancers. These results suggest that chromosome structural organization is fundamental to identify functional somatic alterations in cancer genomes.","5":"Two replicates of SMC1 ChIA-PET in T-ALL Jurkat Cells","6":"[\"ChIA-PET\"]","7":"[\"Human\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645430","17":"Activation of proto-oncogenes by disruption of chromosome neighborhoods","18":"[Activation of proto-oncogenes by disruption of chromosome neighborhoods(PMID:26940867)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26940867)","19":"[GEO:GSE68977](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68977), [SRA:SRP058437](https://www.ncbi.nlm.nih.gov/sra?term=SRP058437)","_rn_":"12"},{"1":"syn21790720","2":"Activation of proto-oncogenes by disruption of chromosome neighborhoods [ChIP-Seq]","3":"PRJNA284251","4":"Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. Recurrent microdeletions frequently overlap neighborhood boundary sites in T-ALL genomes, and we demonstrate that site-specific perturbation of loop boundaries is sufficient to activate the respective proto-oncogenes in non-malignant cells. We found somatic genomic rearrangements affecting loop boundaries in many cancers. These results suggest that chromosome structural organization is fundamental to identify functional somatic alterations in cancer genomes.","5":"CTCF ChIP-seq and input control in Jurkat T-ALL cellsH3K27Ac, RUNX1, and GATA3 ChIP-seq and input control in Jurkat T-ALL cellsCTCF ChIP-seq and input control in wildtype and mutant HEK293T cells","6":"[\"ChIP-Seq\"]","7":"[\"Human\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645430","17":"Activation of proto-oncogenes by disruption of chromosome neighborhoods","18":"[Activation of proto-oncogenes by disruption of chromosome neighborhoods(PMID:26940867)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26940867)","19":"[GEO:GSE68976](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68976), [SRA:SRP058436](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP058436)","_rn_":"13"},{"1":"syn21790733","2":"Activation of proto-oncogenes by disruption of chromosome neighborhoods [RNA-Seq]","3":"PRJNA284252","4":"Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. Recurrent microdeletions frequently overlap neighborhood boundary sites in T-ALL genomes, and we demonstrate that site-specific perturbation of loop boundaries is sufficient to activate the respective proto-oncogenes in non-malignant cells. We found somatic genomic rearrangements affecting loop boundaries in many cancers. These results suggest that chromosome structural organization is fundamental to identify functional somatic alterations in cancer genomes.","5":"Paired-end 80x80 Poly-A RNA-seq in Jurkat T-ALL","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645430","17":"Activation of proto-oncogenes by disruption of chromosome neighborhoods","18":"[Activation of proto-oncogenes by disruption of chromosome neighborhoods(PMID:26940867)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26940867)","19":"[GEO:GSE68975](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68975), [SRA:SRP058435](https://www.ncbi.nlm.nih.gov/sra?term=SRP058435)","_rn_":"14"},{"1":"syn11712135","2":"Expression data from isogenic Pten WT mouse T-ALLs infected with MSCV Myr-AKT-IRES-mCherry or empty vector, treated with DBZ or DMSO","3":"PRJNA290331","4":"To explore the mechanisms downstream of NOTCH1 and PTEN in the control of leukemia cell growth, we performed expression profiling on NOTCH1 induced and Pten-positive T-ALL tumor cells infected with constitutively active AKT (myristoylated-AKT). Constitutive activation of AKT rescues the transcriptional programs induced by NOTCH1 inhibition in Pten-positive T-ALL cells","5":"We performed microarray gene expression analysis of GSI treatment in Pten WT NOTCH1 induced leukemias infected with constitutively active AKT (myristoylated-AKT) or empty vector.","6":"[\"cDNA Array\"]","7":"[\"Mouse\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE71089](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE71089)","_rn_":"15"},{"1":"syn11712136","2":"Expression data from isogenic Pten WT or KO mouse T-ALLs treated with DBZ or DMSO","3":"PRJNA290332","4":"To investigate the underlying mechanisms mediating resistance to NOTCH inhibition in Pten-null T-ALL tumor cells we performed gene expression profiling of isogenic Pten-positive and Pten-deleted leukemia lymphoblasts after acute treatment with DBZ in vivo. This analysis revealed that, while direct NOTCH1 target genes (such as Hes1, Dtx1, PtcrA, HeyL and Notch3) are effectively downregulated in both Pten-positive and Pten-deleted tumors, genetic ablation of Pten elicits a global reversal of much of the transcriptional effects of NOTCH inhibition.","5":"We performed microarray gene expression analysis of GSI treatment in isogenic Pten KO or WT NOTCH1 induced leukemias","6":"[\"cDNA Array\"]","7":"[\"Mouse\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE71087](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE71087)","_rn_":"16"},{"1":"syn11712134","2":"Gene expression profiling of CUTLL cell lines upon 17 drug treatments","3":"PRJNA312888","4":"The clinical development of targeted therapies has been hampered by their limited intrinsic antitumor activity and the rapid emergence of resistance, highlighting the need to identify highly active and synergistic drug combinations. However, empirical synergistic drug screening approaches are challenging and elucidating the mechanisms that underlie such drug interactions is typically complex. Here we performed an expression based screen and network analyses to identify drugs amplyfiying the antitumor effects of NOTCH inhibition in T-ALL. These studies uncovered a novel and druggable synthetic lethal interaction between supression of protein translation and NOTCH inhibition in T-ALL. Our results illustrate the power of expression-based analyses towards the identification and functional characterization of new antitumor drug combinations for the treatment of human cancer.","5":"CUTLL cell lines were treated with drugs (Pyrvinium P, Vorinostat, Geldanamycin, Lanatoside C, Withaferin A, Prochlorperazine, Astemizole, Mefloquine, Trichostatin A, Rapamycin, Parthenolide, Valproic acid, Thioridazine, Trifluoperazine, Phenoxibenzamine, Wortmannin, Resveratrol) or DMSO control at 24hrs in 3 replicates.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE78188](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78188)","_rn_":"17"},{"1":"syn11712133","2":"Gene expression profileing of CUTLL cell lines upon Withaferin A treatment","3":"PRJNA312889","4":"The clinical development of targeted therapies has been hampered by their limited intrinsic antitumor activity and the rapid emergence of resistance, highlighting the need to identify highly active and synergistic drug combinations. However, empirical synergistic drug screening approaches are challenging and elucidating the mechanisms that underlie such drug interactions is typically complex. Here we performed an expression based screen and network analyses to identify drugs amplyfiying the antitumor effects of NOTCH inhibition in T-ALL. These studies uncovered a novel and druggable synthetic lethal interaction between supression of protein translation and NOTCH inhibition in T-ALL. Our results illustrate the power of expression-based analyses towards the identification and functional characterization of new antitumor drug combinations for the treatment of human cancer.","5":"CUTLL cell lines were treated with Withaferin A or DMSO control at 24hrs in 6 replicates.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE78187](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78187)","_rn_":"18"},{"1":"syn18425347","2":"Human basal-like breast cancer cell line HCC1143 treated with BET inhibitor JQ1 with MEK inhibitor Trametinib or PI3K/mTOR inhibitor BEZ235","3":"PRJNA323723","4":"The goal of this experiment was to understand the changes in gene expression in the human basal-like breast cancer cell line HCC1143 following treatment with the MEK inhibitor Trametinib (T), PI3K/mTOR inhibitor BEZ235 (B), the BET inhibition JQ1 (JQ), Trametinib + JQ1 (TJ), or BEZ235 + JQ1(BJ), compared to a DMSO control (D). Samples were treated for 72hr and run in triplicate.","5":"The human basal-like breast cancer cell line HCC1143 was treated for 72hr with 1uM Trametinib (T), 1uM BEZ235, 1uM JQ1 (JQ), 1uM Trametinib + 1uM JQ1 (TJ), 1uM BEZ235 + 1uM JQ1 (BJ), or a 0.05% DMSO control. Total RNA was isolated using a QIAGEN total RNA RNeasy kit, libraries were generated with a Truseq kit, and samples were run on the Nextseq500, data processing is described below.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Ductal Carcinoma\"]","9":"syn21630076, syn21630075, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773345","14":"[\"CA209988\"]","15":"Measuring, Modeling and Controlling Heterogeneity (M2CH)","16":"syn21649001","17":"Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer","18":"[Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer(PMID:30232459)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30232459)","19":"[GEO:GSE82032](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE82032), [SRA:SRP075882](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP075882)","_rn_":"19"},{"1":"syn13858917","2":"Epigenetic restriction of embryonic and extraembryonic lineages mirrors the somatic transition to cancer (ATAC-seq)","3":"PRJNA328459","4":"Concerted efforts over past decades have established a thorough understanding of the canonical somatic DNA methylation landscape as well as its systematic misregulation across most human cancers. However, the underlying mechanism that directs this genome-scale transformation remains elusive, with no clear model for its acquisition or understanding of its potential developmental utility. Here we present base pair resolution analysis of global remethylation from the hypomethylated state of the preimplantation embryo into the early epiblast and extraembryonic ectoderm. We show that these two states acquire highly divergent genomic distributions: while the proximal epiblast establishes a canonical CpG-density dependent pattern found in somatic cells, the extraembryonic epigenome becomes substantially more mosaic. Moreover, this alternate pattern includes specific de novo methylation of hundreds of CpG island promoter containing genes that function in early embryonic development and are orthologously methylated across an extensive cohort of human cancers. From these data, we propose a model where the evolutionary innovation of extraembryonic tissues in eutherian mammals required cooption of DNA methylation-based suppression as an alternate pathway to the embryonically utilized Polycomb group proteins, which otherwise coordinate germ layer formation in response to extraembryonic cues at the onset of gastrulation. Moreover, we establish that this decision is made deterministically downstream of the promiscuously utilized, and frequently oncogenic, FGF signaling pathway and utilizes a novel combination of epigenetic cofactors. Recruitment of this silencing mechanism to developmental genes during cancer therefore reflects the misappropriation of an innate regulatory pathway that may be spontaneously sampled as an alternate epigenetic landscape within somatic cells.","5":"Comparison of chromatin accessibility patterns in Extraembryonic Ectoderm and cancer","6":"[\"ATAC-Seq\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21645383","17":"Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer","18":"[Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer(PMID:28959968)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28959968)","19":"[GEO:GSE84232](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE84232), [SRA:SRP078239](https://www.ncbi.nlm.nih.gov/sra?term=SRP078239)","_rn_":"20"},{"1":"syn13858916","2":"Epigenetic restriction of embryonic and extraembryonic lineages mirrors the somatic transition to cancer (RNA-seq)","3":"PRJNA328460","4":"Concerted efforts over past decades have established a thorough understanding of the canonical somatic DNA methylation landscape as well as its systematic misregulation across most human cancers. However, the underlying mechanism that directs this genome-scale transformation remains elusive, with no clear model for its acquisition or understanding of its potential developmental utility. Here we present base pair resolution analysis of global remethylation from the hypomethylated state of the preimplantation embryo into the early epiblast and extraembryonic ectoderm. We show that these two states acquire highly divergent genomic distributions: while the proximal epiblast establishes a canonical CpG-density dependent pattern found in somatic cells, the extraembryonic epigenome becomes substantially more mosaic. Moreover, this alternate pattern includes specific de novo methylation of hundreds of CpG island promoter containing genes that function in early embryonic development and are orthologously methylated across an extensive cohort of human cancers. From these data, we propose a model where the evolutionary innovation of extraembryonic tissues in eutherian mammals required cooption of DNA methylation-based suppression as an alternate pathway to the embryonically utilized Polycomb group proteins, which otherwise coordinate germ layer formation in response to extraembryonic cues at the onset of gastrulation. Moreover, we establish that this decision is made deterministically downstream of the promiscuously utilized, and frequently oncogenic, FGF signaling pathway and utilizes a novel combination of epigenetic cofactors. Recruitment of this silencing mechanism to developmental genes during cancer therefore reflects the misappropriation of an innate regulatory pathway that may be spontaneously sampled as an alternate epigenetic landscape within somatic cells.","5":"Comparison of gene expression patterns in Extraembryonic Ectoderm and cancer","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21645383","17":"Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer","18":"[Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer(PMID:28959968)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28959968)","19":"[GEO:GSE84234](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE84234), [SRA:SRP078238](https://www.ncbi.nlm.nih.gov/sra?term=SRP078238)","_rn_":"21"},{"1":"syn13858914","2":"Epigenetic restriction of embryonic and extraembryonic lineages mirrors the somatic transition to cancer (WGBS)","3":"PRJNA328546","4":"Concerted efforts over past decades have established a thorough understanding of the canonical somatic DNA methylation landscape as well as its systematic misregulation across most human cancers. However, the underlying mechanism that directs this genome-scale transformation remains elusive, with no clear model for its acquisition or understanding of its potential developmental utility. Here we present base pair resolution analysis of global remethylation from the hypomethylated state of the preimplantation embryo into the early epiblast and extraembryonic ectoderm. We show that these two states acquire highly divergent genomic distributions: while the proximal epiblast establishes a canonical CpG-density dependent pattern found in somatic cells, the extraembryonic epigenome becomes substantially more mosaic. Moreover, this alternate pattern includes specific de novo methylation of hundreds of CpG island promoter containing genes that function in early embryonic development and are orthologously methylated across an extensive cohort of human cancers. From these data, we propose a model where the evolutionary innovation of extraembryonic tissues in eutherian mammals required cooption of DNA methylation-based suppression as an alternate pathway to the embryonically utilized Polycomb group proteins, which otherwise coordinate germ layer formation in response to extraembryonic cues at the onset of gastrulation. Moreover, we establish that this decision is made deterministically downstream of the promiscuously utilized, and frequently oncogenic, FGF signaling pathway and utilizes a novel combination of epigenetic cofactors. Recruitment of this silencing mechanism to developmental genes during cancer therefore reflects the misappropriation of an innate regulatory pathway that may be spontaneously sampled as an alternate epigenetic landscape within somatic cells.","5":"Comparison of DNA methylation patterns in Extraembryonic Ectoderm and cancer","6":"[\"Bisulfite Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21645383","17":"Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer","18":"[Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer(PMID:28959968)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28959968)","19":"[GEO:GSE84235](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE84235), [SRA:SRP078328](https://www.ncbi.nlm.nih.gov/sra?term=SRP078328)","_rn_":"22"},{"1":"syn21792681","2":"Network-based, cross-cohort discovery of transcriptional mechanisms presiding over maintenance of high-risk neuroblastoma subtype state","3":"PRJNA329050","4":"Network-based analysis of neuroblastoma samples from two large cohorts identified master regulator proteins controlling the transcriptional state of three high-risk molecular subtypes. In particular, a TEAD4-MYCN positive feedback loop emerged as the core regulatory motif of a small protein module presiding over implementation and stability of the subtype associated with MYCN amplification. Specifically, MYCN transcriptionally activates TEAD4, which in turn activates MYCN both transcriptionally and post-translationally. The resulting MYCN-TEAD4 positive feedback loop plays a critical role in maintaining aberrant activity of a 10-protein regulatory module that causally regulates the transcriptional state of this subtype. Consistently, loss of TEAD4 activity induces core module activity collapse and abrogates neuroblastoma cell viability in vitro and in vivo, thus suggesting novel therapeutic strategies for this important childhood cancer.","5":"Study of the transcriptional control by TEAD4 and MYCN positive feedback loop using RNA-seq profiles of TEAD4, WWTR1 and MYCN shRNA knockdowns in neuroblastoma BE2 cells. ChIP-Seq analysis using TEAD4 antibody in BE2 cells.","6":"[\"Whole Transcriptome Sequencing\", \"ChIP-Seq\"]","7":"[\"Human\"]","8":"[\"Neuroblastoma\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21648926","17":"Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma","18":"[Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma(PMID:29510988)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29510988)","19":"[GEO:GSE84389](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE84389), [SRA:SRP078495](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP078495)","_rn_":"23"},{"1":"syn21790809","2":"An automatec microwell platform for large-scale single cell RNA-seq.","3":"PRJNA338815","4":"We report an automated microwell array platform for single cell RNA-seq with significantly improved performance over previous implementations. We demonstrate cell capture efficiencies of >50%, compatibility with commercially available barcoded mRNA capture beads, and parallel expression profiling from thousands of individual cells. We apply our system to comprehensively assess heterogeneity in gene expression of patient-derived glioma neurospheres and uncover subpopulations similar to those observed in human glioma tissue.","5":"Performed single cell RNA-seq on thousands of cells from three cell lines.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\", \"Human\"]","8":"[]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127, syn21630128","12":"[\"CSBC\", \"PS-ON\"]","13":"syn7315802, syn7349759","14":"[\"CA209997\", \"CA193313\"]","15":"Center for Cancer Systems Therapeutics (CaST) | Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21645316","17":"An Automated Microwell Platform for Large-Scale Single Cell RNA-Seq","18":"[An Automated Microwell Platform for Large-Scale Single Cell RNA-Seq(PMID:27670648)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27670648)","19":"[GEO:GSE85575](www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85575)","_rn_":"24"},{"1":"syn21792841","2":"HOXA5 is a survival locus associated with chromosome 7 gain in IDH-wildtype glioblastoma","3":"PRJNA352075","4":"Glioblastomas (GBMs) are divided into CpG Island Methylator Phenotype (CIMP) and non-CIMP tumors. Non-CIMP GBMs derive from cells with non-disjunction of chromosome (chr7) and chromosome 10 (chr10), resulting in chr7 gain and chr10 loss, while CIMP GBMs have mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2). Gain of chr7 is largely driven by PDGFA, but other genes on chr7 are likely to contribute to fitness gains and aggressiveness of these GBMs. We computationally investigated genes on chr7 whose gene expression correlated with survival, identifying HOXA5 as a potential driver of proneural gliomagenesis. Using a combination of human GBM cells and mouse PDGF-driven gliomas, we showed that HOXA5 drives increased proliferation and radiation resistance in culture and in vivo. These phenotypes appear to be in part due to effects on p53 and other apoptosis-related genes.","5":"In order to determine whether elevated HOXA5 gene expression is causally related to aggressiveness of non-CIMP PN GBM, we used a PDGF-driven PN GBM mouse model based on the RCAS/tva system to perform gain of function analysis for HOXA5.","6":"[\"Expression Array\"]","7":"[\"Mouse\"]","8":"[\"Glioma\"]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759, syn7349757","14":"[\"CA193313\", \"CA193461\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity | Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"NA","17":"NA","18":"NA","19":"[GSE:GSE89409](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89409)","_rn_":"25"},{"1":"syn12976510","2":"The transcriptome effect of knocking down EZH2 in TamR MCF7L","3":"PRJNA357207","4":"Purpose: Increasing evidence suggests that epigenetic reprogramming contributes significantly to the development of endocrine therapy resistance in breast cancer. The goal of this work is to explore how the histone methyltransferase EZH2 interacts with ER signaling and drives the insensitiveness of breast cancer cells to the antagonistic effect of tamoxifen on ER activity. Therefore, we comprehensively analyzed the transcriptional program regulated by EZH2 in tamoxifen-resistant (TamR) MCF-7 cells. Methods: TamR MCF-7 cells between passage 142-144 upon were used for this assay. For mRNA-Seq, cells are transfected with scrambled control shRNAs (shCtrl) or shRNAs targeting EZH2 (shEZH2). Total RNA were extracted by TRIzol (Invitrogen) and libraries were constructed using Illumina TruSeq RNA Sample Prep Kit v2 (Cat.# RS-122-2001). Hiseq 3000 was used for sequencing.","5":"Transcriptome profiles of Tamoxifen resistance MCF-7 infected with shCtrl or shEZH2 were sequenced in duplicate using Illumina HiSeq 3000.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Ductal Carcinoma\"]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21645251","17":"Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis","18":"[Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis(PMID:29212856)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29212856)","19":"[GEO:GSE92316](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE92316), [SRA:SRP095013](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP095013)","_rn_":"26"},{"1":"syn11958459","2":"PDGF-driven glioblastoma mouse model scRNA-Seq","3":"PRJNA376203","4":"Generate scRNA-Seq profiles for PDGF-driven glioblastoma mouse model.","5":"Obtain 85 scRNA-Seq profiles from a de novo tumor-derived cell line.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"NULL\"]","8":"[\"Glioblastoma\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE95157](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE95157)","_rn_":"27"},{"1":"syn12976726","2":"protein levels in BRAF inhibitor resistance melanoma cells treated with PF3758309","3":"PRJNA379575","4":"11 BRAF inhibitor resistance melanoma cells were treated with PAK inhibitor PF3758309 for 48 hr, the cell lysis were analyzed by RPPA profiling by protein array (RPPA)","5":"11 pair of samples were analyzed (control and PF3758309 treatment group) by RPPA, more than 200 of proteins were tested","6":"[\"RPPA\"]","7":"[\"Human\"]","8":"[\"Melanoma\"]","9":"syn21630078, syn21630081, syn21630079","10":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349747","14":"[\"CA193417\"]","15":"Physical Science Oncology Center at Penn","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE96753](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96753)","_rn_":"28"},{"1":"syn21796984","2":"H-STS NET cell line perturbed with small molecule compounds","3":"PRJNA379584","4":"Expression profile of H-STS NET cell line at 6h and 24h after perturbation with small molecule compounds.","5":"H-STS cells were perturbed with small molecule compounds at isopotent concentrations, corresponding to ED20 and 1/10 of it, as measured by cell viability assays at 60h, or vehicle control (DMSO, ethanol and methanol). The cells were lysed at 6h and 24h after perturbation and total RNA isolated. Libraries for RNA-seq were generated with the TruSeq protocol (Illumina) and sequenced in a Hi-Seq 2500 instrument (Illumina).","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Neuroendocrine Neoplasm\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21681392","17":"A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors","18":"[A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors(PMID:29915428)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29915428)","19":"[GEO:GSE96760](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96760)","_rn_":"29"},{"1":"syn21791505","2":"RNA sequencing of lncRNAs knockdown in human pancreatic cancer cell lines","3":"PRJNA380131","4":"We report the transcriptome changes that result from the transient knockdown of FAM83H-AS1 in Aspc1 cells and transient knockdown of LINC00673 in Panc1 cells.","5":"Total RNA extracted 48 hour after transfection with targeting and control siRNAs. Libraries were prepared from total RNA (RIN>8) with the TruSeq RNA prep kit (Illumina) and sequenced using the HiSeq2500 (Illumina) instrument. Reads were mapped to the human genome (UCSC/hg19) using Tophat (version 2.0.4) with 4 mismatches and 10 maximum multiple hits. Significantly differentially expressed genes were calculated using DESeq2.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Malignant Neoplasm of Pancreas\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127, syn21630128","12":"[\"CSBC\", \"PS-ON\"]","13":"syn7315802, syn7349759","14":"[\"CA209997\", \"CA193313\"]","15":"Center for Cancer Systems Therapeutics (CaST) | Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21648871","17":"Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma","18":"[Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma(PMID:29440233)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29440233)","19":"[GEO:GSE96931](www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96931)","_rn_":"30"},{"1":"syn12976713","2":"Gene expression signature of vemurafenib resistance in WM989 and WM983B melanoma cells","3":"PRJNA382674","4":"Therapies targeting signaling molecules mutated in cancers can often have striking short-term effects, but the emergence of resistant cancer cells is a major barrier to full cures. Resistance can sometimes result from a secondary mutations in rare cells, but other times, there is no clear genetic cause, raising leaving the possibility of non-genetic rare cell variability. Here, we show that melanoma cells can display profound transcriptional variability at the single cell level that predicts which cells will ultimately resist drug treatment. This variability involves semi-coordinated transcription of a number of resistance markers at high levels in a very small percentage of cells. The addition of drug then induces an epigenetic reprogramming in these cells, converting the transient transcriptional state to a stably resistant state. This reprogramming begins withis a progressive process consisting of a loss of SOX10-mediated differentiation followed by activation of new signaling pathways, partially mediated by activity of Jun-AP-1 and TEAD. Our work reveals the multistage nature of the acquisition of drug resistance and provides a framework for understanding resistance dynamics. We find that other cell types also exhibit sporadic expression of many of these same marker genes, suggesting the existence of a general rare-cell expression program.","5":"We performed RNA sequencing on WM989 cells without vemurafenib, after 48 hours of treatment, and upon the development of resistance.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Melanoma\"]","9":"syn21630078, syn21630081, syn21630079","10":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349747","14":"[\"CA193417\"]","15":"Physical Science Oncology Center at Penn","16":"syn21649208","17":"Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance","18":"[Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance(PMID:28607484)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28607484)","19":"[GEO:GSE97681](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97681), [SRA:SRP103828](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP103828)","_rn_":"31"},{"1":"syn12976715","2":"Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance [RNA-seq]","3":"PRJNA382752","4":"Therapies targeting signaling molecules mutated in cancers can often have striking short-term effects, but the emergence of resistant cancer cells is a major barrier to full cures. Resistance can sometimes result from a secondary mutations in rare cells, but other times, there is no clear genetic cause, raising leaving the possibility of non-genetic rare cell variability. Here, we show that melanoma cells can display profound transcriptional variability at the single cell level that predicts which cells will ultimately resist drug treatment. This variability involves semi-coordinated transcription of a number of resistance markers at high levels in a very small percentage of cells. The addition of drug then induces an epigenetic reprogramming in these cells, converting the transient transcriptional state to a stably resistant state. This reprogramming begins with a progressive process consisting of a loss of SOX10-mediated differentiation followed by activation of new signaling pathways, partially mediated by activity of Jun-AP-1 and TEAD. Our work reveals the multistage nature of the acquisition of drug resistance and provides a framework for understanding resistance dynamics. We find that other cell types also exhibit sporadic expression of many of these same marker genes, suggesting the existence of a general rare-cell expression program.","5":"We performed FACS to isolate EGFR-high populations of WM989 melanoma cells at three time points (untreated, 1 week in vemurafenib, 4 weeks in vemurafenib) for RNA sequencing and ATAC sequencing. Each sample has three biological replicates.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Melanoma\"]","9":"syn21630078, syn21630081, syn21630079","10":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349747","14":"[\"CA193417\"]","15":"Physical Science Oncology Center at Penn","16":"syn21649208","17":"Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance","18":"[Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance(PMID:28607484)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28607484)","19":"[GEO:GSE97679](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97679), [SRA:SRP103825](https://www.ncbi.nlm.nih.gov/sra?term=SRP103825)","_rn_":"32"},{"1":"syn12976714","2":"Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance [ATAC-seq]","3":"PRJNA382753","4":"Therapies targeting signaling molecules mutated in cancers can often have striking short-term effects, but the emergence of resistant cancer cells is a major barrier to full cures. Resistance can sometimes result from a secondary mutations in rare cells, but other times, there is no clear genetic cause, raising leaving the possibility of non-genetic rare cell variability. Here, we show that melanoma cells can display profound transcriptional variability at the single cell level that predicts which cells will ultimately resist drug treatment. This variability involves semi-coordinated transcription of a number of resistance markers at high levels in a very small percentage of cells. The addition of drug then induces an epigenetic reprogramming in these cells, converting the transient transcriptional state to a stably resistant state. This reprogramming begins withis a progressive process consisting of a loss of SOX10-mediated differentiation followed by activation of new signaling pathways, partially mediated by activity of Jun-AP-1 and TEAD. Our work reveals the multistage nature of the acquisition of drug resistance and provides a framework for understanding resistance dynamics. We find that other cell types also exhibit sporadic expression of many of these same marker genes, suggesting the existence of a general rare-cell expression program.","5":"We performed FACS to isolate EGFR-high populations of WM989 melanoma cells at three time points (untreated, 1 week in vemurafenib, 4 weeks in vemurafenib) for RNA sequencing and ATAC sequencing. Each sample has three biological replicates.","6":"[\"ATAC-Seq\"]","7":"[\"Human\"]","8":"[\"Melanoma\"]","9":"syn21630078, syn21630081, syn21630079","10":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349747","14":"[\"CA193417\"]","15":"Physical Science Oncology Center at Penn","16":"syn21649208","17":"Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance","18":"[Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance(PMID:28607484)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28607484)","19":"[GEO:GSE97680](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97680), [SRA:SRP103827](https://www.ncbi.nlm.nih.gov/sra?term=SRP103827)","_rn_":"33"},{"1":"syn13858909","2":"Epigenetic restriction of embryonic and extraembryonic lineages mirrors the somatic transition to cancer (Perturbation-RNAseq)","3":"PRJNA386938","4":"Concerted efforts over past decades have established a thorough understanding of the canonical somatic DNA methylation landscape as well as its systematic misregulation across most human cancers. However, the underlying mechanism that directs this genome-scale transformation remains elusive, with no clear model for its acquisition or understanding of its potential developmental utility. Here we present base pair resolution analysis of global remethylation from the hypomethylated state of the preimplantation embryo into the early epiblast and extraembryonic ectoderm. We show that these two states acquire highly divergent genomic distributions: while the proximal epiblast establishes a canonical CpG-density dependent pattern found in somatic cells, the extraembryonic epigenome becomes substantially more mosaic. Moreover, this alternate pattern includes specific de novo methylation of hundreds of CpG island promoter containing genes that function in early embryonic development and are orthologously methylated across an extensive cohort of human cancers. From these data, we propose a model where the evolutionary innovation of extraembryonic tissues in eutherian mammals required cooption of DNA methylation-based suppression as an alternate pathway to the embryonically utilized Polycomb group proteins, which otherwise coordinate germ layer formation in response to extraembryonic cues at the onset of gastrulation. Moreover, we establish that this decision is made deterministically downstream of the promiscuously utilized, and frequently oncogenic, FGF signaling pathway and utilizes a novel combination of epigenetic cofactors. Recruitment of this silencing mechanism to developmental genes during cancer therefore reflects the misappropriation of an innate regulatory pathway that may be spontaneously sampled as an alternate epigenetic landscape within somatic cells.","5":"Comparison of gene expression patterns in Extraembryonic Ectoderm and cancer","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21645383","17":"Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer","18":"[Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer(PMID:28959968)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28959968)","19":"[GEO:GSE98960](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98960), [SRA:SRP107205](https://www.ncbi.nlm.nih.gov/sra?term=SRP107205)","_rn_":"34"},{"1":"syn21813402","2":"Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.","3":"PRJNA387311","4":"We compared three CDK4/6 inhibitors that have recently emerged as highly promising agents for advanced breast cancers by performing transcriptional profiling (mRNA-Seq) on a panel of seven breast cancer cell lines following 6 or 24 hours of drug exposure at concentrations ranging from 0.3 to 3.0 uM.","5":"mRNA levels for 7 breast cancer cell lines treated with one of three CDK4/6 inhibitors (abemaciclib, palbociclib, or ribociclib) at either 0.3 uM, 1.0 uM (only for MCF7), or 3.0 uM for either 6 or 24 hours.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681801","17":"Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity","18":"[Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity(PMID:31178407)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31178407)","19":"[GEO:GSE99116](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99116)","_rn_":"35"},{"1":"syn12976509","2":"The transcriptome effect of overexpressing EZH2 in MCF7","3":"PRJNA400606","4":"Purpose: Increasing evidence suggests that epigenetic reprogramming contributes significantly to the development of endocrine therapy resistance in breast cancer. The goal of this work is to explore how the histone methyltransferase EZH2 interacts with ER signaling and drives the insensitiveness of breast cancer cells to the antagonistic effect of tamoxifen on ER activity. Therefore, we comprehensively analyzed the transcriptional program regulated by EZH2 in EZH2 overexpressed MCF-7 cells. Methods: MCF-7 cells between passage 142-144 were used for this assay. For mRNA-Seq, cells are infected with control empty vector (EV) or EZH2 expressing plasmid (EZH2) by lentivirus. Total RNA were extracted by TRIzol (Invitrogen) and libraries were constructed using Illumina TruSeq RNA Sample Prep Kit v2 (Cat.# RS-122-2001). Hiseq 3000 was used for sequencing.","5":"Transcriptome profiles of tamoxifen sensitive MCF-7 infected with pLenti-CMV-hygro-GFP or pLento-HA-EZH2 were sequenced in at least duplicates using Illumina HiSeq 3000.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Ductal Carcinoma\"]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21645251","17":"Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis","18":"[Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis(PMID:29212856)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29212856)","19":"[GEO:GSE103242](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103242)","_rn_":"36"},{"1":"syn21810340","2":"KDM5B links cellular transcriptome heterogeneity to therapy resistance (RNA-Seq)","3":"PRJNA414329","4":"The KDM5B histone H3 lysine 4 (H3K4) demethylase has been implicated in therapy resistance in multiple cancer types including breast cancer, but the underlying mechanism is poorly defined. Here we show that inhibition of KDM5B activity increases sensitivity to anti-estrogens by modulating estrogen-receptor (ER) signaling. Conversely, acquired resistance to KDM5 inhibitors leads to gain of ER chromatin binding and estrogen-independent growth. Sequencing of barcoded cell populations and mathematical modeling demonstrate selection for pre-existent genetically distinct endocrine-resistant cells, while resistance to KDM5 inhibitors is a switch to an acquired epigenetic state. Rare resistant cells can already be detected by single cell RNA-seq prior to treatment. Inhibition of KDM5B in luminal ER+ cells increases H3K4me3 broad domains at promoters and decreases cellular transcriptional heterogeneity. Higher transcriptome heterogeneity is associated with higher KDM5B levels and poor prognosis in ER+ luminal breast tumors.","5":"RNA-Seq of parental and multiple resistant breast cancer cell lines","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681468","17":"KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance","18":"[KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance(PMID:30472020)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30472020)","19":"[GEO:GSE104985](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104985), [SRA:SRP119970](https://www.ncbi.nlm.nih.gov/sra?term=SRP119970)","_rn_":"37"},{"1":"syn21810581","2":"KDM5B links cellular transcriptome heterogeneity to therapy resistance (Exome-Seq)","3":"PRJNA414330","4":"The KDM5B histone H3 lysine 4 (H3K4) demethylase has been implicated in therapy resistance in multiple cancer types including breast cancer, but the underlying mechanism is poorly defined. Here we show that inhibition of KDM5B activity increases sensitivity to anti-estrogens by modulating estrogen-receptor (ER) signaling. Conversely, acquired resistance to KDM5 inhibitors leads to gain of ER chromatin binding and estrogen-independent growth. Sequencing of barcoded cell populations and mathematical modeling demonstrate selection for pre-existent genetically distinct endocrine-resistant cells, while resistance to KDM5 inhibitors is a switch to an acquired epigenetic state. Rare resistant cells can already be detected by single cell RNA-seq prior to treatment. Inhibition of KDM5B in luminal ER+ cells increases H3K4me3 broad domains at promoters and decreases cellular transcriptional heterogeneity. Higher transcriptome heterogeneity is associated with higher KDM5B levels and poor prognosis in ER+ luminal breast tumors.","5":"Exome-seq of parental and multiple resistant breast cancer cell lines","6":"[\"Whole Exome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681468","17":"KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance","18":"[KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance(PMID:30472020)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30472020)","19":"[GEO:GSE104984](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104984), [SRA:SRP119969](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP119969)","_rn_":"38"},{"1":"syn21810592","2":"KDM5B links cellular transcriptome heterogeneity to therapy resistance (ChIP-Seq)","3":"PRJNA414331","4":"The KDM5B histone H3 lysine 4 (H3K4) demethylase has been implicated in therapy resistance in multiple cancer types including breast cancer, but the underlying mechanism is poorly defined. Here we show that inhibition of KDM5B activity increases sensitivity to anti-estrogens by modulating estrogen-receptor (ER) signaling. Conversely, acquired resistance to KDM5 inhibitors leads to gain of ER chromatin binding and estrogen-independent growth. Sequencing of barcoded cell populations and mathematical modeling demonstrate selection for pre-existent genetically distinct endocrine-resistant cells, while resistance to KDM5 inhibitors is a switch to an acquired epigenetic state. Rare resistant cells can already be detected by single cell RNA-seq prior to treatment. Inhibition of KDM5B in luminal ER+ cells increases H3K4me3 broad domains at promoters and decreases cellular transcriptional heterogeneity. Higher transcriptome heterogeneity is associated with higher KDM5B levels and poor prognosis in ER+ luminal breast tumors.","5":"ChIP-Seq of parental and multiple resistant breast cancer cell lines","6":"[\"ChIP-Seq\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681468","17":"KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance","18":"[KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance(PMID:30472020)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30472020)","19":"[GEO:GSE104983](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104983), [SRA:SRP119968](https://www.ncbi.nlm.nih.gov/sra?term=SRP119968)","_rn_":"39"},{"1":"syn21810955","2":"KDM5B links cellular transcriptome heterogeneity to therapy resistance (Barcode)","3":"PRJNA414333","4":"The KDM5B histone H3 lysine 4 (H3K4) demethylase has been implicated in therapy resistance in multiple cancer types including breast cancer, but the underlying mechanism is poorly defined. Here we show that inhibition of KDM5B activity increases sensitivity to anti-estrogens by modulating estrogen-receptor (ER) signaling. Conversely, acquired resistance to KDM5 inhibitors leads to gain of ER chromatin binding and estrogen-independent growth. Sequencing of barcoded cell populations and mathematical modeling demonstrate selection for pre-existent genetically distinct endocrine-resistant cells, while resistance to KDM5 inhibitors is a switch to an acquired epigenetic state. Rare resistant cells can already be detected by single cell RNA-seq prior to treatment. Inhibition of KDM5B in luminal ER+ cells increases H3K4me3 broad domains at promoters and decreases cellular transcriptional heterogeneity. Higher transcriptome heterogeneity is associated with higher KDM5B levels and poor prognosis in ER+ luminal breast tumors.","5":"Barcoding analyses of parental and multiple resistant breast cancer cell lines","6":"[\"Barcode-Seq\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681468","17":"KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance","18":"[KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance(PMID:30472020)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30472020)","19":"[GEO:GSE104981](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104981), [SRA:SRP119966](https://www.ncbi.nlm.nih.gov/sra?term=SRP119966)","_rn_":"40"},{"1":"syn21810301","2":"KDM5B links cellular transcriptome heterogeneity to therapy resistance (RRBS)","3":"PRJNA414334","4":"The KDM5B histone H3 lysine 4 (H3K4) demethylase has been implicated in therapy resistance in multiple cancer types including breast cancer, but the underlying mechanism is poorly defined. Here we show that inhibition of KDM5B activity increases sensitivity to anti-estrogens by modulating estrogen-receptor (ER) signaling. Conversely, acquired resistance to KDM5 inhibitors leads to gain of ER chromatin binding and estrogen-independent growth. Sequencing of barcoded cell populations and mathematical modeling demonstrate selection for pre-existent genetically distinct endocrine-resistant cells, while resistance to KDM5 inhibitors is a switch to an acquired epigenetic state. Rare resistant cells can already be detected by single cell RNA-seq prior to treatment. Inhibition of KDM5B in luminal ER+ cells increases H3K4me3 broad domains at promoters and decreases cellular transcriptional heterogeneity. Higher transcriptome heterogeneity is associated with higher KDM5B levels and poor prognosis in ER+ luminal breast tumors.","5":"Reduced representation bisulfite sequencing (RRBS) was performed on parental and multiple resistant breast cancer cell lines","6":"[\"Bisulfite Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681468","17":"KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance","18":"[KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance(PMID:30472020)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30472020)","19":"[GEO:GSE104986](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104986), [SRA:SRP119971](https://www.ncbi.nlm.nih.gov/sra?term=SRP119971)","_rn_":"41"},{"1":"syn21810294","2":"KDM5B links cellular transcriptome heterogeneity to therapy resistance (inDrop)","3":"PRJNA414337","4":"The KDM5B histone H3 lysine 4 (H3K4) demethylase has been implicated in therapy resistance in multiple cancer types including breast cancer, but the underlying mechanism is poorly defined. Here we show that inhibition of KDM5B activity increases sensitivity to anti-estrogens by modulating estrogen-receptor (ER) signaling. Conversely, acquired resistance to KDM5 inhibitors leads to gain of ER chromatin binding and estrogen-independent growth. Sequencing of barcoded cell populations and mathematical modeling demonstrate selection for pre-existent genetically distinct endocrine-resistant cells, while resistance to KDM5 inhibitors is a switch to an acquired epigenetic state. Rare resistant cells can already be detected by single cell RNA-seq prior to treatment. Inhibition of KDM5B in luminal ER+ cells increases H3K4me3 broad domains at promoters and decreases cellular transcriptional heterogeneity. Higher transcriptome heterogeneity is associated with higher KDM5B levels and poor prognosis in ER+ luminal breast tumors.","5":"Single cell transcriptome of parental and multiple resistant breast cancer cell lines","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681468","17":"KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance","18":"[KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance(PMID:30472020)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30472020)","19":"[GEO:GSE104987](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE104987), [SRA:SRP119973](https://www.ncbi.nlm.nih.gov/sra?term=SRP119973)","_rn_":"42"},{"1":"syn21792855","2":"Ivy Glioblastoma Atlas Project (RNA-Seq)","3":"PRJNA420740","4":"The Ivy Glioblastoma Atlas Project (Ivy GAP) is a detailed anatomically based transcriptomic atlas of human glioblastoma tumors. As collaborators, the Ivy Foundation funded the Allen Institute and the Swedish Neuroscience Institute to design and create the atlas. The Paul G. Allen Family Foundation also supported the project. This resource consists of a viewer interface that resolves the manually- and machine-annotated histologic images (H&E and RNA in situ hybridization) at 0.5 <U+00B5>m/pixel, a transcriptome browser to view and mine the anatomically-based RNA-Seq samples, an application programming interface, help documentation that describes the methods and how to use the resource, as well as SNP array data and the supporting longitudinal clinical information and MRI time course data. The resource is made available to the public without charge as part of the Ivy GAP (http://glioblastoma.alleninstitute.org/) via the Allen Institute data portal (http://www.brain-map.org), the Ivy GAP Clinical and Genomic Database (http://ivygap.org/) via the Swedish Neuroscience Institute (http://www.swedish.org/services/neuroscience-institute), and The Cancer Imaging Archive (https://wiki.cancerimagingarchive.net/display/Public/Ivy+GAP). The Ivy GAP processed data at GEO includes normalized RNA-Seq FPKM files used for analysis in \"An anatomic transcriptional atlas of glioblastoma,<U+201D> which is under review. Other processed data files as well as sample and donor meta-data and QC metrics are available at http://glioblastoma.alleninstitute.org/static/download.html. The raw RNA-Seq and SNP array data will be submitted to dbGaP.","5":"The Ivy Glioblastoma Atlas is based on the analysis of ~400 tissue blocks from 42 tumors donated by 41 patients. A machine learning application was developed to label over ~12,000 H&E images of 7 x 9 mm tissue sections cut adjacent to ~24,000 sections for RNA in situ hybridization (ISH) analyzed with over 500 probes. Accuracy of the machine annotations was assessed with neuropathology concordance analyses. Transcriptomic profiles were generated from 270 RNA-Seq samples collected by laser microdissection. The anatomic structures data set consists of 122 RNA samples of 5 anatomic features of the tumors: leading edge (LE), infiltrating tumor (IT), cellular tumor (CT), pseudopalisading cells around necrosis (PAN), microvascular proliferation (MVP) identified by H&E staining in 10 tumors. The cancer stem cells data set consists of 148 RNA samples of putative cancer stem cell clusters identified by ISH with 18 probe reference set in 34 tumors. The sequencing results were aligned and aggregated at the gene level using the RSEM algorithm, and the resulting fpkm values were normalized across all samples based on genes not enriched in particular anatomic structures. For more details, please see the Downloads tab in the Ivy Glioblastoma Atlas web application.-------------------------------Authors state \"Raw files will be made available through dbGaP.\"","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE107559](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE107559)","_rn_":"43"},{"1":"syn21792856","2":"Ivy Glioblastoma Atlas Project (SNP)","3":"PRJNA420741","4":"The Ivy Glioblastoma Atlas Project (Ivy GAP) is a detailed anatomically based transcriptomic atlas of human glioblastoma tumors. As collaborators, the Ivy Foundation funded the Allen Institute and the Swedish Neuroscience Institute to design and create the atlas. The Paul G. Allen Family Foundation also supported the project. This resource consists of a viewer interface that resolves the manually- and machine-annotated histologic images (H&E and RNA in situ hybridization) at 0.5 <U+00B5>m/pixel, a transcriptome browser to view and mine the anatomically-based RNA-Seq samples, an application programming interface, help documentation that describes the methods and how to use the resource, as well as SNP array data and the supporting longitudinal clinical information and MRI time course data. The resource is made available to the public without charge as part of the Ivy GAP (http://glioblastoma.alleninstitute.org/) via the Allen Institute data portal (http://www.brain-map.org), the Ivy GAP Clinical and Genomic Database (http://ivygap.org/) via the Swedish Neuroscience Institute (http://www.swedish.org/services/neuroscience-institute), and The Cancer Imaging Archive (https://wiki.cancerimagingarchive.net/display/Public/Ivy+GAP). The Ivy GAP processed data at GEO includes normalized RNA-Seq FPKM files used for analysis in \"An anatomic transcriptional atlas of glioblastoma,<U+201D> which is under review. Other processed data files as well as sample and donor meta-data and QC metrics are available at http://glioblastoma.alleninstitute.org/static/download.html. The raw RNA-Seq and SNP array data will be submitted to dbGaP.","5":"Copy number analysis was performed using Affymetrix GenomeWideSNP_6 platform. A total of 35 samples were used from 34 GBM patients<U+2019> and 1 glioma patient<U+2019>s surgical resections.--------------------------------Authors state \"Raw files will be made available through dbGaP.\"","6":"[\"Single Nucleotide Polymorphism Array\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE107558](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE107558)","_rn_":"44"},{"1":"syn21797980","2":"The mammalian decidual cell evolved from a cellular stress response","3":"PRJNA430399","4":"Among animal species, cell types vary greatly in terms of number and kind. The broad range of number of cell types among species suggests that cell type origination is a significant source of evolutionary novelty. The molecular mechanisms giving rise to novel cell types, however, are poorly understood. Here we show that a novel cell type of eutherians mammals, the decidual stromal cell (DSC), evolved by rewiring an ancestral cellular stress response. We isolated the precursor cell type of DSCs, endometrial stromal fibroblasts (ESFs), from the opossum Monodelphis domestica. We show that, in opossum ESF, the majority of decidual core regulatory genes respond to decidualizing signals, but do not regulate decidual effector genes. Rather, in opossum ESF, decidual transcription factors function in apoptotic and oxidative stress response. We propose that the rewiring of cellular stress responses could be a general mechanism for the evolution of novel cell types.","5":"Examination of mRNA profiles of in vitro cultured opossum endometrial stromal fibroblasts and those exposed to: 1) eutherian differentiation media, containing cyclic AMP (cAMP) analogue 8-Br-cAMP and the progesterone (P4) analogue medroxyprogesterone acetate (MPA), 2) MPA, 3) PGE2, 4) PGE2 and MPA.","6":"[]","7":"[\"Opossum\"]","8":"[]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315810","14":"[\"CA209992\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion","16":"syn21681412","17":"The mammalian decidual cell evolved from a cellular stress response","18":"[The mammalian decidual cell evolved from a cellular stress response(PMID:30142145)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30142145)","19":"[GEO:GSE109309](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109309)","_rn_":"45"},{"1":"syn21809570","2":"Effect of global MYC DNA binding due to loss of PIN1","3":"PRJNA430961","4":"The goal of this study was to determine the MYC binding difference between WT and PIN1 knockout mouse embryonic fibroblasts.","5":"Wildtype and PIN1 knockout MEFs were serum starved for 48 hours, and stimulated 4hrs to induce MYC expression. DNA IPed from N262 antibody was harvested from 2 independent experimental replicates per genotype.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630075, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773345","14":"[\"CA209988\"]","15":"Measuring, Modeling and Controlling Heterogeneity (M2CH)","16":"syn21649183","17":"Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals","18":"[Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals(PMID:30366908)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30366908)","19":"[GEO:GSE109458](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109458)","_rn_":"46"},{"1":"syn21809579","2":"Transcriptional changes of serum stimulation in mouse embryonic fibroblasts due to loss of PIN1","3":"PRJNA430962","4":"The goal of this study was to determine the transcriptional difference between WT and PIN1 knockout mouse embryonic fibroblasts.","5":"Wildtype and PIN1 knockout MEFs were serum starved for 48 hours, and stimulated 4hrs to induce MYC expression. RNA was harvested from 2 independent experimental replicates per genotype.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630075, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773345","14":"[\"CA209988\"]","15":"Measuring, Modeling and Controlling Heterogeneity (M2CH)","16":"syn21649183","17":"Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals","18":"[Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals(PMID:30366908)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30366908)","19":"[GEO:GSE109457](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109457)","_rn_":"47"},{"1":"syn21812470","2":"DNA:cytoplasm ratio defines an upper limit to cell size [RNA-seq]","3":"PRJNA434318","4":"Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important is not understood. Here we show that growing beyond a certain size has wide-ranging effects on cell physiology. Large cells are defective in gene induction, cell cycle progression and cell signaling. We further show that these defects are caused by the inability of large cells to scale nucleic acid and protein biosynthesis in accordance with cell volume increase, which effectively leads to cytoplasm dilution. Finally, we determine why nucleic acid and protein biosynthesis do not scale with cell volume beyond a certain critical size. DNA becomes limiting. We conclude that the correct DNA to cytoplasm ratio is vital for many perhaps all cellular functions and that the range where this ratio supports optimal cell function is remarkably narrow.","5":"Total RNA sequenced from fixed numbers of S. cerevisiae cells of varying size mixed with a fixed number exponentially growing C. albicans cells. The S. cerevisiae counts were normalized to total number of C.albicans reads in each sample.","6":"[]","7":"[\"Yeast\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773338","14":"[\"CA217377\"]","15":"Quantitative and Functional Characterization of Therapeutic Resistance in Cancer","16":"syn21681553","17":"Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence","18":"[Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence(PMID:30739799)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30739799)","19":"[GEO:GSE110704](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110704), [SRA:SRP132956](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP132956)","_rn_":"48"},{"1":"syn21812461","2":"DNA:cytoplasm ratio defines an upper limit to cell size [array]","3":"PRJNA435760","4":"Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important is not understood. Here we show that growing beyond a certain size has wide-ranging effects on cell physiology. Large cells are defective in gene induction, cell cycle progression and cell signaling. We further show that these defects are caused by the inability of large cells to scale nucleic acid and protein biosynthesis in accordance with cell volume increase, which effectively leads to cytoplasm dilution. Finally, we determine why nucleic acid and protein biosynthesis do not scale with cell volume beyond a certain critical size. DNA becomes limiting. We conclude that the correct DNA to cytoplasm ratio is vital for many perhaps all cellular functions and that the range where this ratio supports optimal cell function is remarkably narrow.","5":"Two-color microarray experiment comparing gene expression of S. cerevisiae cells of different cell size before and after 40 minutes of alpha factor exposure.\\nThe cell sizes are:\\nWT: 50 fL\\n2h: 250 fL\\n6h: 815 fL\\n6h CHX: 325 fL","6":"[]","7":"[\"Yeast\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773338","14":"[\"CA217377\"]","15":"Quantitative and Functional Characterization of Therapeutic Resistance in Cancer","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE111075](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE111075)","_rn_":"49"},{"1":"syn21812572","2":"RNA sequencing data","3":"PRJNA446003","4":"RNA sequencing data of AdGFP cell from mouse PDAC","5":"6 mouse PDAC cell lines were infected with Adeno GFP","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Pancreatic Ductal Adenocarcinoma\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127, syn21630128","12":"[\"CSBC\", \"PS-ON\"]","13":"syn7315802, syn7349759","14":"[\"CA209997\", \"CA193313\"]","15":"Center for Cancer Systems Therapeutics (CaST) | Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21681640","17":"Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF","18":"[Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF(PMID:30975481)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30975481)","19":"[GEO:GSE112434](www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112434)","_rn_":"50"},{"1":"syn21797571","2":"Molecular characterization of neuroendocrine prostate cancer organoids and PDOX by RNA-seq","3":"PRJNA449096","4":"We report the generation and characterization of tumor organoids and PDOX derived from needle biopsies of metastatic lesions from neuroendocrine prostate cancer patients.","5":"Understanding the expression profile of neuroendocrine prostate cancer tumor organoids and PDOXs.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of prostate\"]","9":"syn21630080, syn21630078, syn21630079","10":"[\"Metabolism\", \"Microenvironment\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349770","14":"[\"CA210184\"]","15":"Center on the Physics of Cancer Metabolism","16":"syn21648964","17":"Patient derived organoids to model rare prostate cancer phenotypes","18":"[Patient derived organoids to model rare prostate cancer phenotypes(PMID:29921838)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29921838)","19":"[GEO:GSE112786](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112786), [SRA:SRP137893](https://www.ncbi.nlm.nih.gov/sra?term=SRP137893)","_rn_":"51"},{"1":"syn21797564","2":"Methylation profile of neuroendocrine prostate cancer models","3":"PRJNA449098","4":"Our study represents a detailed molecular analysis of neuroenedocrine prostate cancer models","5":"Understanding the global methylation profile of tumor organoids and PDOXs.","6":"[\"Bisulfite Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of prostate\"]","9":"syn21630080, syn21630078, syn21630079","10":"[\"Metabolism\", \"Microenvironment\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349770","14":"[\"CA210184\"]","15":"Center on the Physics of Cancer Metabolism","16":"syn21648964","17":"Patient derived organoids to model rare prostate cancer phenotypes","18":"[Patient derived organoids to model rare prostate cancer phenotypes(PMID:29921838)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29921838)","19":"[GEO:GSE112829](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112829), [SRA:SRP137894](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP137894)","_rn_":"52"},{"1":"syn21795292","2":"Single Cell RNA sequencing of Adult Human Breast Epithelial Cells [C1_Individual_2]","3":"PRJNA450371","4":"Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of heterogeneity and differentiation hierarchy in the human breast remains elusive. Here, we used single-cell mRNA sequencing (scRNAseq) to profile the transcriptomes of 25,790 primary human breast epithelial cells isolated from reduction mammoplasties of seven individuals. Unbiased clustering analysis reveals the existence of three distinct epithelial cell populations, one basal and two luminal cell types, which we identify as secretory L1- and hormone-responsive L2-type cells. Pseudotemporal reconstruction of differentiation trajectories produc one continuous lineage hierarchy that closely connects the basal lineage to the two differentiated luminal branches. Our comprehensive cell atlas provides novel insights into cellular blueprint of the human breast epithelium and will form the foundation to understand how the system goes awry during breast cancer.","5":"Microfluidics-enabled Single Cell RNA sequencing libraries were generated for 3 adult human women using the Fluidigm C1 and sequenced on the Illumina HighSeq 2500","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9774783","14":"[\"CA199315\"]","15":"Integrative approach to heterogeneity in breast cancer metastasis","16":"syn21649156","17":"Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity","18":"[Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity(PMID:29795293)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29795293)","19":"[GEO:GSE113127](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113127), [SRA:SRP140489](https://www.ncbi.nlm.nih.gov/sra?term=SRP140489)","_rn_":"53"},{"1":"syn21795809","2":"Single Cell RNA sequencing of Adult Human Breast Epithelial Cells [C1_Individual_1]","3":"PRJNA450372","4":"Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of heterogeneity and differentiation hierarchy in the human breast remains elusive. Here, we used single-cell mRNA sequencing (scRNAseq) to profile the transcriptomes of 25,790 primary human breast epithelial cells isolated from reduction mammoplasties of seven individuals. Unbiased clustering analysis reveals the existence of three distinct epithelial cell populations, one basal and two luminal cell types, which we identify as secretory L1- and hormone-responsive L2-type cells. Pseudotemporal reconstruction of differentiation trajectories produc one continuous lineage hierarchy that closely connects the basal lineage to the two differentiated luminal branches. Our comprehensive cell atlas provides novel insights into cellular blueprint of the human breast epithelium and will form the foundation to understand how the system goes awry during breast cancer.","5":"Microfluidics-enabled Single Cell RNA sequencing libraries were generated for 3 adult human women using the Fluidigm C1 and sequenced on the Illumina HighSeq 2500","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9774783","14":"[\"CA199315\"]","15":"Integrative approach to heterogeneity in breast cancer metastasis","16":"syn21649156","17":"Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity","18":"[Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity(PMID:29795293)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29795293)","19":"[GEO:GSE113099](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113099), [SRA:SRP140488](https://www.ncbi.nlm.nih.gov/sra?term=SRP140488)","_rn_":"54"},{"1":"syn21793531","2":"Single Cell RNA sequencing of Adult Human Breast Epithelial Cells","3":"PRJNA450409","4":"This SuperSeries is composed of the SubSeries listed below.","5":"Refer to individual Series","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9774783","14":"[\"CA199315\"]","15":"Integrative approach to heterogeneity in breast cancer metastasis","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE113197](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113197)","_rn_":"55"},{"1":"syn21795279","2":"Single Cell RNA sequencing of Adult Human Breast Epithelial Cells [Individual 4..7]","3":"PRJNA450410","4":"Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of heterogeneity and differentiation hierarchy in the human breast remains elusive. Here, we used single-cell mRNA sequencing (scRNAseq) to profile the transcriptomes of 25,790 primary human breast epithelial cells isolated from reduction mammoplasties of seven individuals. Unbiased clustering analysis reveals the existence of three distinct epithelial cell populations, one basal and two luminal cell types, which we identify as secretory L1- and hormone-responsive L2-type cells. Pseudotemporal reconstruction of differentiation trajectories produc one continuous lineage hierarchy that closely connects the basal lineage to the two differentiated luminal branches. Our comprehensive cell atlas provides novel insights into cellular blueprint of the human breast epithelium and will form the foundation to understand how the system goes awry during breast cancer.","5":"Droplet Based Single Cell RNA sequencing libraries were generated for 4 adult human women using the 10x Genomics Chromium Platform and sequenced on the Illumina HighSeq 4000","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9774783","14":"[\"CA199315\"]","15":"Integrative approach to heterogeneity in breast cancer metastasis","16":"syn21649156","17":"Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity","18":"[Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity(PMID:29795293)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29795293)","19":"[GEO:GSE113196](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113196)","_rn_":"56"},{"1":"syn21792875","2":"Single Cell RNA sequencing of Adult Human Breast Epithelial Cells [C1_Individual_3]","3":"PRJNA450412","4":"Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of heterogeneity and differentiation hierarchy in the human breast remains elusive. Here, we used single-cell mRNA sequencing (scRNAseq) to profile the transcriptomes of 25,790 primary human breast epithelial cells isolated from reduction mammoplasties of seven individuals. Unbiased clustering analysis reveals the existence of three distinct epithelial cell populations, one basal and two luminal cell types, which we identify as secretory L1- and hormone-responsive L2-type cells. Pseudotemporal reconstruction of differentiation trajectories produc one continuous lineage hierarchy that closely connects the basal lineage to the two differentiated luminal branches. Our comprehensive cell atlas provides novel insights into cellular blueprint of the human breast epithelium and will form the foundation to understand how the system goes awry during breast cancer.","5":"Microfluidics-enabled Single Cell RNA sequencing libraries were generated for 3 adult human women using the Fluidigm C1 and sequenced on the Illumina HighSeq 2500","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9774783","14":"[\"CA199315\"]","15":"Integrative approach to heterogeneity in breast cancer metastasis","16":"syn21649156","17":"Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity","18":"[Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity(PMID:29795293)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29795293)","19":"[GEO:GSE113198](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113198), [SRA:SRP140536](https://www.ncbi.nlm.nih.gov/sra?term=SRP140536)","_rn_":"57"},{"1":"syn21809459","2":"Colonic single-cell RNA-seq experiment","3":"PRJNA461797","4":"WT untreated C57Bl6 mouse","5":"3 replicates from different mice in single sequencing run","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\", \"Human\"]","8":"[]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084053","14":"[\"CA215798\"]","15":"Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy","16":"syn21649039","17":"Quantitative assessment of cell population diversity in single-cell landscapes","18":"[Quantitative assessment of cell population diversity in single-cell landscapes(PMID:30346945)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30346945)","19":"[GEO:GSE114044](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114044), [SRA:SRP144614](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP144614)","_rn_":"58"},{"1":"syn21811318","2":"Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation","3":"PRJNA464059","4":"Measuring multiple omics profiles from the same single cell opens up the opportunity to decode molecular regulation that underlies intercellular heterogeneity in development and disease. Here, we present co-sequencing of microRNAs and mRNAs in the same single cells using a half-cell genomics approach. This method demonstrates good robustness (~95% success rate) and reproducibility (R2=0.93 for both microRNAs and mRNAs), yielding paired half-cell microRNA and mRNA profiles that we can independently validate. By linking the level of microRNAs to the expression of predicted target mRNAs across 19 single cells that are phenotypically identical, we observe that the predicted targets are significantly anti-correlated with the variation of abundantly expressed microRNAs. This suggests that microRNA expression variability alone may lead to non-genetic cell-to-cell heterogeneity. Genome-scale analysis of paired microRNA-mRNA co-profiles further allows us to derive and validate regulatory relationships of cellular pathways controlling microRNA expression and intercellular variability.","5":"This dataset contains single cell small RNA sequencing and RNA-seq analysis of K562 cells. Single K562 cells were subjected to small RNA sequencing and/or RNAseq analyses using a half-cell approach. Included in this dataset are twenty K562 cells with paired small RNA and RNAseq data.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Acute Myeloid Leukemia\"]","9":"syn21630078, syn21630079","10":"[\"Microenvironment\", \"Metastasis\"]","11":"syn21630127, syn21630128","12":"[\"CSBC\", \"PS-ON\"]","13":"syn7315810, syn7349757","14":"[\"CA209992\", \"CA193461\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion | Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681514","17":"Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation","18":"[Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation(PMID:30626865)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30626865)","19":"[GEO:GSE114071](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114071), [SRA:SRP144659](https://www.ncbi.nlm.nih.gov/sra?term=SRP144659)","_rn_":"59"},{"1":"syn18475750","2":"Single-cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment - 5' RNA sequencing and TCR sequencing","3":"PRJNA472381","4":"Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We created an immune map of breast cancer using single-cell RNA-seq data from 45,000 immune cells from eight breast carcinomas, as well as matched normal breast tissue, blood, and lymph node. We developed a preprocessing pipeline, SEQC, and a Bayesian clustering and normalization method, Biscuit, to address computational challenges inherent to single-cell data. Despite significant similarity between normal and tumor tissue-resident immune cells, we observed continuous phenotypic expansions specific to the tumor microenvironment. Analysis of paired single-cell RNA and T cell receptor (TCR) sequencing data from 27,000 additional T cells revealed the combinatorial impact of TCR utilization on phenotypic diversity. Our results support a model of continuous activation in T cells and do not comport with the macrophage polarization model in cancer, with important implications for characterizing tumor-infiltrating immune cells.<U+00A0>","5":"Single-cell RNA sequencing was performed on three patients using the 10x genomics TCR profiling kits. For each patient, populations of T-cells were assayed for both TCR sequence and trancriptome-wide RNA-sequence. Two donors have a replicate experiment.","6":"[\"Single Cell Sequencing\"]","7":"[\"Human\"]","8":"[\"Intraductal Carcinoma in situ of Breast\"]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21649215","17":"Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment","18":"[Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment(PMID:29961579)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29961579)","19":"[GEO:GSE114724](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114724), [SRA:SRP148594](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP148594)","_rn_":"60"},{"1":"syn18475749","2":"Single-cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment 3' RNA Sequencing","3":"PRJNA472383","4":"Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We created an immune map of breast cancer using single-cell RNA-seq data from 45,000 immune cells from eight breast carcinomas, as well as matched normal breast tissue, blood, and lymph node. We developed a preprocessing pipeline, SEQC, and a Bayesian clustering and normalization method, Biscuit, to address computational challenges inherent to single-cell data. Despite significant similarity between normal and tumor tissue-resident immune cells, we observed continuous phenotypic expansions specific to the tumor microenvironment. Analysis of paired single-cell RNA and T cell receptor (TCR) sequencing data from 27,000 additional T cells revealed the combinatorial impact of TCR utilization on phenotypic diversity. Our results support a model of continuous activation in T cells and do not comport with the macrophage polarization model in cancer, with important implications for characterizing tumor-infiltrating immune cells.<U+00A0>","5":"Single-cell RNA sequencing was performed on eight donors using the InDrop v2 protocol. For each donor populations of CD45+ immune cells were assayed for trancriptome-wide RNA-sequence. At least one replicate was taken for each donor.","6":"[\"Single Cell Sequencing\"]","7":"[\"Human\"]","8":"[\"Intraductal Carcinoma in situ of Breast\"]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21649215","17":"Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment","18":"[Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment(PMID:29961579)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29961579)","19":"[GEO:GSE114725](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114725)","_rn_":"61"},{"1":"syn21799939","2":"The effect of cellular context on miR-155 mediated gene regulation in four major immune cell types (RNA-Seq)","3":"PRJNA478229","4":"Numerous microRNAs and their target mRNAs are co-expressed across diverse cell types. However, it is unknown whether they are regulated in a cellular context-independent or -dependent manner. Here, we explored transcriptome-wide targeting and gene regulation by miR-155, whose activation-induced expression plays important roles in innate and adaptive immunity. Through mapping of miR-155 targets using differential Argonaute iCLIP, mRNA quantification with RNA-Seq, and 3<U+2019>UTR usage analysis using polyadenylation (polyA)-Seq in activated miR-155-sufficient and deficient macrophages, dendritic cells, T and B lymphocytes, we identified numerous targets differentially bound by miR-155. While alternative cleavage and polyadenylation (ApA) contributed to differential miR-155 binding to some transcripts, in a majority of cases identical 3<U+2019>UTR isoforms were differentially regulated across cell types, suggesting ApA-independent and cellular context-dependent miR-155-mediated gene regulation reminiscent of sequence-specific transcription factors. Our study provides comprehensive maps of miR-155 regulatory RNA networks and offers a valuable resource for dissecting context-dependent and -independent miRNA-mediated gene regulation in key cell types of the adaptive and innate immune systems.","5":"Primary dendritic cells, B cells, CD4 T cells, and macrophages from C57BL/6J wild type and miR-155 KO mice were cultured in RPMI medium with 10% FBS. Prior to harvesting primary dendritic cells, mice were subcutaneously injected with one million B16 melanoma cells expressing Flt3 ligand for about two weeks. After purification of splenic CD11c+ dendritic cells by CD11c microbeads (Miltenyi Biotec), dendritic cells were activated in a medium containing 100 ng/ml LPS (SIGMA) and 20 ng/ml GMSCF (Tonbo). Splenic primary B cells were purified by negative selection using Dynabeads Mouse CD43 (Invitrogen), and activated in a medium containing 25 ug/ml LPS and 6.5 ng/ml mIL4 (PeproTech). CD4 T cells from lymph node and spleen were purified with Dynabeads FlowComp Kit (Invitrogen). CD4+CD25-CD44- T cells were then activated with Dynabeads Mouse T-Activator CD3/CD28 (Invitrogen). Intraperitoneal macrophages, induced by thioglycollate injection, were harvested and activated with 100 ng/ml LPS. Each condition has 3 sequencing replicates.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21649050","17":"The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types","18":"[The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types(PMID:30224821)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30224821)","19":"[GEO:GSE116348](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116348), [SRA:SRP151472](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP151472)","_rn_":"62"},{"1":"syn21799873","2":"The effect of cellular context on miR-155 mediated gene regulation in four major immune cell types (iCLIP)","3":"PRJNA478598","4":"Numerous microRNAs and their target mRNAs are co-expressed across diverse cell types. However, it is unknown whether they are regulated in a cellular context-independent or -dependent manner. Here, we explored transcriptome-wide targeting and gene regulation by miR-155, whose activation-induced expression plays important roles in innate and adaptive immunity. Through mapping of miR-155 targets using differential Argonaute iCLIP, mRNA quantification with RNA-Seq, and 3<U+2019>UTR usage analysis using polyadenylation (polyA)-Seq in activated miR-155-sufficient and deficient macrophages, dendritic cells, T and B lymphocytes, we identified numerous targets differentially bound by miR-155. While alternative cleavage and polyadenylation (ApA) contributed to differential miR-155 binding to some transcripts, in a majority of cases identical 3<U+2019>UTR isoforms were differentially regulated across cell types, suggesting ApA-independent and cellular context-dependent miR-155-mediated gene regulation reminiscent of sequence-specific transcription factors. Our study provides comprehensive maps of miR-155 regulatory RNA networks and offers a valuable resource for dissecting context-dependent and -independent miRNA-mediated gene regulation in key cell types of the adaptive and innate immune systems.","5":"Primary dendritic cells, B cells, CD4 T cells, and macrophages from C57BL/6J wild type and miR-155 KO mice were cultured in RPMI medium with 10% FBS. Prior to harvesting primary dendritic cells, mice were subcutaneously injected with one million B16 melanoma cells expressing Flt3 ligand for about two weeks. After purification of splenic CD11c+ dendritic cells by CD11c microbeads (Miltenyi Biotec), dendritic cells were activated in a medium containing 100 ng/ml LPS (SIGMA) and 20 ng/ml GMSCF (Tonbo). Splenic primary B cells were purified by negative selection using Dynabeads Mouse CD43 (Invitrogen), and activated in a medium containing 25 ug/ml LPS and 6.5 ng/ml mIL4 (PeproTech). CD4 T cells from lymph node and spleen were purified with Dynabeads FlowComp Kit (Invitrogen). CD4+CD25-CD44- T cells were then activated with Dynabeads Mouse T-Activator CD3/CD28 (Invitrogen). Intraperitoneal macrophages, induced by thioglycollate injection, were harvested and activated with 100 ng/ml LPS. Each condition has 4 sequencing replicates.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21649050","17":"The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types","18":"[The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types(PMID:30224821)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30224821)","19":"[GEO:GSE116466](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116466)","_rn_":"63"},{"1":"syn21799792","2":"The effect of cellular context on miR-155 mediated gene regulation in four major immune cell types (PolyA-Seq)","3":"PRJNA478602","4":"Numerous microRNAs and their target mRNAs are co-expressed across diverse cell types. However, it is unknown whether they are regulated in a cellular context-independent or -dependent manner. Here, we explored transcriptome-wide targeting and gene regulation by miR-155, whose activation-induced expression plays important roles in innate and adaptive immunity. Through mapping of miR-155 targets using differential Argonaute iCLIP, mRNA quantification with RNA-Seq, and 3<U+2019>UTR usage analysis using polyadenylation (polyA)-Seq in activated miR-155-sufficient and deficient macrophages, dendritic cells, T and B lymphocytes, we identified numerous targets differentially bound by miR-155. While alternative cleavage and polyadenylation (ApA) contributed to differential miR-155 binding to some transcripts, in a majority of cases identical 3<U+2019>UTR isoforms were differentially regulated across cell types, suggesting ApA-independent and cellular context-dependent miR-155-mediated gene regulation reminiscent of sequence-specific transcription factors. Our study provides comprehensive maps of miR-155 regulatory RNA networks and offers a valuable resource for dissecting context-dependent and -independent miRNA-mediated gene regulation in key cell types of the adaptive and innate immune systems.","5":"Primary dendritic cells, B cells, CD4 T cells, and macrophages from C57BL/6J wild type and miR-155 KO mice were cultured in RPMI medium with 10% FBS. Prior to harvesting primary dendritic cells, mice were subcutaneously injected with one million B16 melanoma cells expressing Flt3 ligand for about two weeks. After purification of splenic CD11c+ dendritic cells by CD11c microbeads (Miltenyi Biotec), dendritic cells were activated in a medium containing 100 ng/ml LPS (SIGMA) and 20 ng/ml GMSCF (Tonbo). Splenic primary B cells were purified by negative selection using Dynabeads Mouse CD43 (Invitrogen), and activated in a medium containing 25 ug/ml LPS and 6.5 ng/ml mIL4 (PeproTech). CD4 T cells from lymph node and spleen were purified with Dynabeads FlowComp Kit (Invitrogen). CD4+CD25-CD44- T cells were then activated with Dynabeads Mouse T-Activator CD3/CD28 (Invitrogen). Intraperitoneal macrophages, induced by thioglycollate injection, were harvested and activated with 100 ng/ml LPS.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21649050","17":"The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types","18":"[The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types(PMID:30224821)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30224821)","19":"[GEO:GSE116468](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116468)","_rn_":"64"},{"1":"syn21813568","2":"RNA-seq of Single-Cell Genotyping of Transcriptomes","3":"PRJNA483241","4":"Somatic cancer driver mutations may result in distinctly diverging phenotypic outputs. Thus, a common driver lesion may result in cancer subtypes with distinct clinical presentations and outcomes. The diverging phenotypic outputs of mutations result from the superimposition of the mutations with distinct progenitor cell populations that have differing lineage potential. However, our ability to test this hypothesis has been challenged by currently available tools. For example, flow cytometry is limited in its inability to resolve lineage commitment of early progenitors. Single-cell RNA sequencing (scRNA-seq) may provide higher resolution mapping of the early progenitor populations as long as high throughput technology is available to sequence thousands of single cells. Nevertheless, high throughput scRNA-seq is limited in its inability to jointly and robustly detect the mutational status and the transcriptional profile from the same cell. To overcome these limitations, we propose the use of scRNA-seq combined with targeted mutation sequencing from transcrptional read-outs.","5":"We apply this method to study myeloid neopasms, in which the comlex process of hematopoiesis is corrupted by mutated stem and progenitor cells.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\", \"Mouse\"]","8":"[]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21681828","17":"Somatic mutations and cell identity linked by Genotyping of Transcriptomes","18":"[Somatic mutations and cell identity linked by Genotyping of Transcriptomes(PMID:31270458)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31270458)","19":"[GEO:GSE117824](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117824), [SRA:SRP155569](https://www.ncbi.nlm.nih.gov/sra?term=SRP155569)","_rn_":"65"},{"1":"syn21813561","2":"Amplicon of Single-Cell Genotyping of Transcriptomes","3":"PRJNA483242","4":"Somatic cancer driver mutations may result in distinctly diverging phenotypic outputs. Thus, a common driver lesion may result in cancer subtypes with distinct clinical presentations and outcomes. The diverging phenotypic outputs of mutations result from the superimposition of the mutations with distinct progenitor cell populations that have differing lineage potential. However, our ability to test this hypothesis has been challenged by currently available tools. For example, flow cytometry is limited in its inability to resolve lineage commitment of early progenitors. Single-cell RNA sequencing (scRNA-seq) may provide higher resolution mapping of the early progenitor populations as long as high throughput technology is available to sequence thousands of single cells. Nevertheless, high throughput scRNA-seq is limited in its inability to jointly and robustly detect the mutational status and the transcriptional profile from the same cell. To overcome these limitations, we propose the use of scRNA-seq combined with targeted mutation sequencing from transcrptional read-outs.","5":"We apply this method to study myeloid neopasms, in which the comlex process of hematopoiesis is corrupted by mutated stem and progenitor cells.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\", \"Mouse\"]","8":"[]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21681828","17":"Somatic mutations and cell identity linked by Genotyping of Transcriptomes","18":"[Somatic mutations and cell identity linked by Genotyping of Transcriptomes(PMID:31270458)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31270458)","19":"[GEO:GSE117825](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117825), [SRA:SRP155570](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP155570)","_rn_":"66"},{"1":"syn21799588","2":"Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq [WES]","3":"PRJNA485428","4":"Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conduct single-cell RNA- sequencing (scRNA-seq) of >1500 cells from six primary TNBC, together with whole exome sequencing (WES) for four of the tumors. Intercellular heterogeneity of gene expression programs within each tumor was variable and largely correlated with clonality of inferred genomic copy number changes, suggesting that genotype drives the gene expression phenotype of individual subpopulations. Clustering of gene expression profiles identified distinct subgroups of malignant cells shared by multiple tumors, including a single subpopulation associated with multiple signatures of treatment resistance and metastasis, and characterized functionally by activation of glycosphingolipid metabolism and associated innate immunity pathways. A novel signature defining this subpopulation was predictive of long-term outcomes for TNBC patients in a large patient cohort. Collectively, this analysis reveals the functional heterogeneity and its association with genomic evolution in TNBC, and uncovers unanticipated biological principles dictating poor outcomes in this disease.","5":"Whole exome sequencing of 4 FFPE TNBC samples and 1 lymphoblastoid cell line","6":"[\"Whole Exome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681417","17":"Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq","18":"[Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq(PMID:30181541)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30181541)","19":"[GEO:GSE118303](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118303), [SRA:SRP157038](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP157038)","_rn_":"67"},{"1":"syn21798003","2":"Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq [RNA-Seq]","3":"PRJNA485429","4":"Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conduct single-cell RNA- sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Intercellular heterogeneity of gene expression programs within each tumor was variable and largely correlated with clonality of inferred genomic copy number changes, suggesting that genotype drives the gene expression phenotype of individual subpopulations. Clustering of gene expression profiles identified distinct subgroups of malignant cells shared by multiple tumors, including a single subpopulation associated with multiple signatures of treatment resistance and metastasis, and characterized functionally by activation of glycosphingolipid metabolism and associated innate immunity pathways. A novel signature defining this subpopulation was predictive of long-term outcomes for TNBC patients in a large patient cohort. Collectively, this analysis reveals the functional heterogeneity and its association with genomic evolution in TNBC, and uncovers unanticipated biological principles dictating poor outcomes in this disease.","5":"Single cell RNA sequencing of 1,534 cells in six fresh triple negative breast cancer tumors.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681417","17":"Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq","18":"[Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq(PMID:30181541)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30181541)","19":"[GEO:GSE118389](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118389), [SRA:SRP157044](https://www.ncbi.nlm.nih.gov/sra?term=SRP157044)","_rn_":"68"},{"1":"syn21812540","2":"Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells","3":"PRJNA488269","4":"Using the recently described CD104+/CD44hi antigen combination we demonstrate that tumorigenicity depends on individual cells residing in a hybrid E/M state. Acquisition of this E/M hybrid state is facilitated by the differential expression of EMT- TFs, like Snail accompanied by the expression of adult stem-cell programs. Transition from the highly tumorigenic E/M state to a fully mesenchymal phenotype, achieved by constitutive ectopic expression of Zeb1, is sufficient to drive cells out of the E/M hybrid state into an extreme mesenchymal (xM) state, which is accompanied by a substantial loss of tumorigenicity and a switch from canonical to non-canonical Wnt signaling.","5":"Performing RNASeq with HMLE (immortalized human mammary epithelial cells) in different EMT stages, either in the E state the hybrid E/M state or the extreme mesenchymal (xM) state as determined by sorting for CD104 and CD44. And performing RNASeq with HMLE cells locked in the xE state by Zeb1KO (xE-SCC-Zeb1KO), from there transferred to the hybrid E/M state by Snail overexpression (E-SCC-Zeb1KOSn) or rescued and transitioned to an xM state with CRISPR resistant Zeb1 wobble mutant (mt) (E-SCC-Zeb1KOSnZmt).","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630079, syn21630075","10":"[\"Metastasis\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775689","14":"[\"CA184897\"]","15":"Dynamics of Gene and Isoform Regulation during EMT and tumor progression","16":"NA","17":"Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells","18":"[\"Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells(PMID: 30910979)\"](https://www.ncbi.nlm.nih.gov/pubmed/30910979)","19":"[GEO:GSE119149](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119149)","_rn_":"69"},{"1":"syn21814115","2":"Ptpn2 regulates the generation of cytotoxic Tim-3+ CD8+ T cells and restrains anti-tumor immunity","3":"PRJNA488638","4":"Cellular and transcriptional experiments demonstrate that deletion of Ptpn2 enhances CD8+ T cell responses to chronic viral infection and cancer.","5":"Murine bone-marrow chimeras were generated by intravenous transfer of lineage- Sca-1+ Kit+ (LSK) cells, derived from a CD45.1+ Cas9+ expressing mouse and infected with either control or Ptpn2-targeting sgRNAs, into irradiated recipient CD45.2 mice. CD8+ cells derived from the reconstituted hematopoetic compartment of the recipient mice were then isolated for transfer to host mice. For LCMV co-transfer studies, cells were transferred (500:500 mix) to recipient mice on day -1, and mice were infected with LCMV Clone 13 on day 0. For tumor co-transfer studies, cells were transferred (1000:1000 mix) to recipient mice on day -1, and mice were injected with MC38-OVA or B16-OVA on day 0. Day 7 or 8 post tumor or virus injection respectively, co-transferred T cells were isolated from the tumor or spleen (LCMV) (as above) and replicates of 500 cells were FACS sorted for transcriptional profiling.\\nA file with detailed methods is included at the foot of this record.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681909","17":"PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity","18":"[PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity(PMID:31527834)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31527834)","19":"[GEO:GSE119270](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119270), [SRA:SRP159185](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP159185)","_rn_":"70"},{"1":"syn21812492","2":"Acidification of tumor: stromal boundaries drive transcriptome alterations associated with aggressive phenotypes","3":"PRJNA489852","4":"We report RNA splicing changes in response to extracellular acidification","5":"MDA-MB-231 and 4T1 mammary carcinoma cell lines were exposed to 48hrs of low pH conditions generated by changes in sodium bicarbonate concentrations.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\", \"Mouse\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630079, syn21630075","10":"[\"Metastasis\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775689","14":"[\"CA184897\"]","15":"Dynamics of Gene and Isoform Regulation during EMT and tumor progression","16":"NA","17":"Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes","18":"[\"Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes(PMID: 30755444)\"](https://www.ncbi.nlm.nih.gov/pubmed/30755444)","19":"[GEO:GSE119646](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119646), [SRA:SRP160142](https://www.ncbi.nlm.nih.gov/sra?term=SRP160142)","_rn_":"71"},{"1":"syn21814201","2":"Gastric organoid single-cell RNA-seq II","3":"PRJNA499102","4":"Meta4 gastric organoids from Mist1-creERT2/+;KrasLSL/+ mice treated with vehicle or Selumetinib","5":"Meta4+DMSO vs. Meta4+Selumetinib","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084053","14":"[\"CA215798\"]","15":"Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy","16":"syn21681992","17":"Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach","18":"[Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach(PMID:31804471)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31804471)","19":"[GEO:GSE121939](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121939), [SRA:SRP167164](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP167164)","_rn_":"72"},{"1":"syn21814206","2":"Gastric organoid single-cell RNA-seq I","3":"PRJNA499104","4":"Meta3 and Meta4 gastric organoids from Mist1-creERT2/+;KrasLSL/+ mice","5":"Meta3 vs. Meta4","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084053","14":"[\"CA215798\"]","15":"Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy","16":"syn21681992","17":"Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach","18":"[Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach(PMID:31804471)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31804471)","19":"[GEO:GSE121937](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121937), [SRA:SRP167161](https://www.ncbi.nlm.nih.gov/sra?term=SRP167161)","_rn_":"73"},{"1":"syn21812977","2":"Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma","3":"PRJNA504903","4":"we used gene expression profiling to determine gene expression changes in sensitive and drug tolerant medulloblastoma cells to reexposure to BET-bromodomain inhibitors","5":"Cells were treated with 1uM of DMSO or JQ1 and RNA-extracted at 24 hours","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE122404](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122404)","_rn_":"74"},{"1":"syn21813337","2":"RNAseq based trascript profilling of MCF7-xenograft mice treated with one of three CDK4/6 inhibitiors","3":"PRJNA514039","4":"We compare differences in gene expression induced after treating MCF7-xenograft mice with either ribociclib, palbociclib, or abemacicilb daily for 4 days.","5":"Mice were engrafted with MCF7 cells in each flank and allowed to grow to ~300 mm3. The animals were then randomly assigned to treatment groups, and treated daily for four days with ribociclib (150 mg/kg), palbociclib (150 mg/kg), abemaciclib (25, 75, 100, 125, or 150 mg/kg), or vehicle control (0.5% (w/v)","6":"[]","7":"[\"Mouse\", \"Human\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681801","17":"Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity","18":"[Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity(PMID:31178407)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31178407)","19":"[GEO:GSE124854](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124854), [SRA:SRP178115](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP178115)","_rn_":"75"},{"1":"syn21812592","2":"Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes","3":"PRJNA516881","4":"The perivascular niche (PVN) plays an essential role in brain tumor stem-like cell (BTSC) fate control, tumor invasion, and therapeutic resistance. We use a microvasculature-on-a-chip system as a PVN model to evaluate the ex vivo dynamics of BTSCs from ten glioblastoma patients. BTSCs were found to preferentially localize in the perivascular zone, where they exhibited either the lowest motility, as in quiescent cells, or the highest motility, as in the invasive phenotype, with migration over long distance. The degree of co-localization between tumor cells and microvessels varied significantly across patients. To validate these results from the microvasculature-on-a-chip system, single-cell transcriptome sequencing (10 patients and 21,750 single cells in total) was performed to identify tumor cell subtypes. The co-localization coefficient was found to positively correlate with proneural (stem-like) or mesenchymal (invasive) but not classical (proliferative) tumor cells. Furthermore, a gene signature profile including PDGFRA correlated strongly with the <U+201C>homing<U+201D> of tumor cells to the PVN. These findings demonstrate that our BTSC-on-a-chip model can recapitulate in vivo tumor cell dynamics and heterogeneity, representing a new route to study patient-specific tumor cell functions.","5":"Single cell RNA-seq of human glioblastoma cells from 10 patients.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630078, syn21630079","10":"[\"Microenvironment\", \"Metastasis\"]","11":"syn21630127, syn21630128","12":"[\"CSBC\", \"PS-ON\"]","13":"syn7315810, syn7349757","14":"[\"CA209992\", \"CA193461\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion | Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681676","17":"Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes","18":"[Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes(PMID:31016107)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31016107)","19":"[GEO:GSE125587](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125587), [SRA:SRP181871](https://www.ncbi.nlm.nih.gov/sra?term=SRP181871)","_rn_":"76"},{"1":"syn21813700","2":"A non-canonical role of<U+00A0>YAP/TEAD<U+00A0>is required for activation of<U+00A0>estrogen-regulated enhancers in breast cancer [ChIP-seq]","3":"PRJNA516895","4":"Estrogen and estrogen receptor alpha (ER<U+03B1>) signaling plays an essential role in ER<U+03B1>-positive breast cancer. ER<U+03B1> mainly occupies on distal enhancers within genome and requires the cooperation of additional co-factors to tune the enhancer activity. Through in vivo proximity-dependent labeling technique BioID, we identified YAP1 and TEAD4 protein as novel co-regulators of ER<U+03B1>. YAP and TEAD are nuclear effectors of the Hippo pathway regulating cell proliferation, organ size and tumorigenesis. Their non-canonical function as transcriptional co-regulators for other signals have been reported but remains under investigated. Our ChIP-seq data in both MCF7 and T47D breast cancer cell lines indicated that YAP1 and TEAD4 co-bind to the strongest estrogen-responsive ER<U+03B1>-bound enhancers, and their bindings are augmented upon E2 stimulation. Knockdown of YAP1 or TEAD4 showed a global effect on the induction of E2/ER<U+03B1> target genes as examined by RNA-seq, also on E2-induced oncogenic growth of ER-positive breast cancer cells. We used Global Run-on sequencing (GRO-seq) assays to test the expression of enhancer non-coding RNAs (eRNAs), which are sensitive markers for estrogen-induced enhancer activation. Our results supported our hypothesis that the recruitment YAP/TEAD to ER<U+03B1>-bound enhancers is required for enhancer activation. Further studies revealed that the binding of YAP1 on ER<U+03B1> enhancers is a prerequisite for the recruitment of the enhancer activation machinery component MED1. These findings indicate that ER<U+03B1> collaborates with YAP1 and TEAD4 to activate or maintain its enhancer activity. Our data reveals a non-canonical function of YAP1 and TEAD4, which is independent of their canonical target genes, in regulating cancer growth, highlighting the potential of YAP1 and TEAD4 as actionable drug targets for ER<U+03B1>-positive breast cancer.","5":"Chromatin immunoprecipitation (ChIP) assay followed by high-throughput sequencing (ChIP-seq).","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681836","17":"A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer","18":"[A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer(PMID:31303470)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31303470)","19":"[GEO:GSE125594](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125594)","_rn_":"77"},{"1":"syn21813687","2":"A non-canonical role of<U+00A0>YAP/TEAD<U+00A0>is required for activation of<U+00A0>estrogen-regulated enhancers in breast cancer [RNA-seq]","3":"PRJNA516911","4":"Estrogen and estrogen receptor alpha (ER<U+03B1>) signaling plays an essential role in ER<U+03B1>-positive breast cancer. ER<U+03B1> mainly occupies on distal enhancers within genome and requires the cooperation of additional co-factors to tune the enhancer activity. Through in vivo proximity-dependent labeling technique BioID, we identified YAP1 and TEAD4 protein as novel co-regulators of ER<U+03B1>. YAP and TEAD are nuclear effectors of the Hippo pathway regulating cell proliferation, organ size and tumorigenesis. Their non-canonical function as transcriptional co-regulators for other signals have been reported but remains under investigated. Our ChIP-seq data in both MCF7 and T47D breast cancer cell lines indicated that YAP1 and TEAD4 co-bind to the strongest estrogen-responsive ER<U+03B1>-bound enhancers, and their bindings are augmented upon E2 stimulation. Knockdown of YAP1 or TEAD4 showed a global effect on the induction of E2/ER<U+03B1> target genes as examined by RNA-seq, also on E2-induced oncogenic growth of ER-positive breast cancer cells. We used Global Run-on sequencing (GRO-seq) assays to test the expression of enhancer non-coding RNAs (eRNAs), which are sensitive markers for estrogen-induced enhancer activation. Our results supported our hypothesis that the recruitment YAP/TEAD to ER<U+03B1>-bound enhancers is required for enhancer activation. Further studies revealed that the binding of YAP1 on ER<U+03B1> enhancers is a prerequisite for the recruitment of the enhancer activation machinery component MED1. These findings indicate that ER<U+03B1> collaborates with YAP1 and TEAD4 to activate or maintain its enhancer activity. Our data reveals a non-canonical function of YAP1 and TEAD4, which is independent of their canonical target genes, in regulating cancer growth, highlighting the potential of YAP1 and TEAD4 as actionable drug targets for ER<U+03B1>-positive breast cancer.","5":"Total RNA extraction followed by high-throughput sequencing (RNA-seq).","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681836","17":"A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer","18":"[A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer(PMID:31303470)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31303470)","19":"[GEO:GSE125606](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125606)","_rn_":"78"},{"1":"syn21813674","2":"A non-canonical role of<U+00A0>YAP/TEAD<U+00A0>is required for activation of<U+00A0>estrogen-regulated enhancers in breast cancer [GRO-seq]","3":"PRJNA516912","4":"Estrogen and estrogen receptor alpha (ER<U+03B1>) signaling plays an essential role in ER<U+03B1>-positive breast cancer. ER<U+03B1> mainly occupies on distal enhancers within genome and requires the cooperation of additional co-factors to tune the enhancer activity. Through in vivo proximity-dependent labeling technique BioID, we identified YAP1 and TEAD4 protein as novel co-regulators of ER<U+03B1>. YAP and TEAD are nuclear effectors of the Hippo pathway regulating cell proliferation, organ size and tumorigenesis. Their non-canonical function as transcriptional co-regulators for other signals have been reported but remains under investigated. Our ChIP-seq data in both MCF7 and T47D breast cancer cell lines indicated that YAP1 and TEAD4 co-bind to the strongest estrogen-responsive ER<U+03B1>-bound enhancers, and their bindings are augmented upon E2 stimulation. Knockdown of YAP1 or TEAD4 showed a global effect on the induction of E2/ER<U+03B1> target genes as examined by RNA-seq, also on E2-induced oncogenic growth of ER-positive breast cancer cells. We used Global Run-on sequencing (GRO-seq) assays to test the expression of enhancer non-coding RNAs (eRNAs), which are sensitive markers for estrogen-induced enhancer activation. Our results supported our hypothesis that the recruitment YAP/TEAD to ER<U+03B1>-bound enhancers is required for enhancer activation. Further studies revealed that the binding of YAP1 on ER<U+03B1> enhancers is a prerequisite for the recruitment of the enhancer activation machinery component MED1. These findings indicate that ER<U+03B1> collaborates with YAP1 and TEAD4 to activate or maintain its enhancer activity. Our data reveals a non-canonical function of YAP1 and TEAD4, which is independent of their canonical target genes, in regulating cancer growth, highlighting the potential of YAP1 and TEAD4 as actionable drug targets for ER<U+03B1>-positive breast cancer.","5":"Global Run On (GRO) assay followed by high-throughput sequencing (GRO-seq).","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681836","17":"A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer","18":"[A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer(PMID:31303470)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31303470)","19":"[GEO:GSE125607](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125607), [SRA:SRP181911](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP181911)","_rn_":"79"},{"1":"syn21813547","2":"Single-cell integrative analysis of CAR-T cell activation reveals a predominantly TH1/TH2 mixed response independent of differentiation","3":"PRJNA529684","4":"We present the first comprehensive portrait of single-cell level transcriptional and cytokine signatures of anti-CD19 4-1BB/CD28/CD3<U+03B6> CAR-T cells upon antigen-specific stimulation. Both CD4+<U+00A0><U+2018>helper<U+2019> and CD8+<U+00A0>cytotoxic CAR-T cells are equally effective in directly killing target tumor cells and their cytotoxic activity is associated with the elevation of a range of TH1 and TH2 signature cytokines (e.g., IFN<U+03B3>, TNF<U+03B1>, IL5, and IL13), as confirmed by the expression of master transcription factors TBX21 (Tbet) and GATA-3. However, rather than conforming to stringent TH1 or TH2 subtypes, single-cell analysis reveals that the predominant response is a highly mixed TH1/TH2 function in the same cell and the regulatory T cell (Treg) activity, although observed in a small fraction of activated cells, emerges from this hybrid TH1/TH2 population. GM-CSF is produced from the majority of cells regardless of the polarization states, further contrasting CAR-T to classic T cells. Surprisingly, the cytokine response is minimally associated with differentiation status although all major differentiation subsets such as na<U+00EF>ve, central memory, effector memory and effector are detected. All these suggest that the activation of CAR-engineered T cells is a canonical process that leads to a highly mixed response combining both type 1 and type 2 cytokines together with GM-CSF, supporting the notion that <U+2018>polyfunctional<U+2019> CAR-T cells correlate with objective response of patients in clinical trials. This work provides new insights to the mechanism of CAR activation and implies the necessity for cellular function assays to characterize the quality of CAR-T infusion products and monitor therapeutic responses in patients.","5":"Single-cell analysis of CAR-T activation states (unstimulated control, Raji-stimulated)","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[]","9":"syn21630078, syn21630079","10":"[\"Microenvironment\", \"Metastasis\"]","11":"syn21630127, syn21630128","12":"[\"CSBC\", \"PS-ON\"]","13":"syn7315810, syn7349757","14":"[\"CA209992\", \"CA193461\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion | Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681820","17":"Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation","18":"[Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation(PMID:31229590)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31229590)","19":"[GEO:GSE129007](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129007), [SRA:SRP189782](https://www.ncbi.nlm.nih.gov/sra?term=SRP189782)","_rn_":"80"},{"1":"syn21813534","2":"MULTI-seq: Universal sample multiplexing for single-cell RNA sequencing using lipid-tagged indices","3":"PRJNA531855","4":"We report the development of MULTI-seq: a scRNA-seq and snRNA-seq sample multiplexing approach using lipid- or cholesterol-modified oligonucleotides. We demonstrate MULTI-seq utility in the following scRNA-seq and snRNA-seq contexts: (1) Live HEKs and HMECs with and without stimulation with TGF-<U+03B2>, (2) Purified nuclei from HEKs, MEFs, and Jurkats stimulated for 0-24 hrs with ionomycin and PMA, (3) 96 unique HMEC cultures (with one technical replicate), and (4) human metastases and mouse immune cells isolated from cryopreserved primary tissue samples dissected from a patient-derived xenograft mouse model of triple-negative breast cancer at progressive stages of metastasis to the lung.","5":"Single-cell or single-nucleus gene expression profiles for (1) HEKs and HMECs, (2) HEKs, MEFs, and Jurkats, (3) HMECs in distinct culture conditions, and (4) Human metastases and mouse immune cells from PDX mice.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\", \"Mouse\"]","8":"[]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9774783","14":"[\"CA199315\"]","15":"Integrative approach to heterogeneity in breast cancer metastasis","16":"NA","17":"MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.","18":"[MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. (PMID: 31209384)](https://www.ncbi.nlm.nih.gov/pubmed/31209384)","19":"[GEO:GSE129578](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129578), [SRA:SRP192397](https://www.ncbi.nlm.nih.gov/sra?term=SRP192397)","_rn_":"81"},{"1":"syn21813795","2":"Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells [RNA-Seq]","3":"PRJNA549474","4":"CD8+<U+00A0>cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+<U+00A0>T cells and identified regulators of tumor infiltration and killing, which are directly relevant to cancer immunotherapy. Unlike in vitro screens, the in vivo screen robustly re-identified canonical immunotherapy targets such as PD-1 and Tim-3, along with genes that have not been characterized in T cells. The infiltration and degranulation screens converged on an RNA helicase Dhx37. Dhx37 knockout enhanced the efficacy of antigen-specific CD8+<U+00A0>T cells against cancer in vivo. Immunological characterization in mouse and human CD8+<U+00A0>T cells revealed that DHX37 suppresses effector function, cytokine production, and T cell activation. Transcriptomic profiling and biochemical interrogation revealed a role for DHX37 in modulating the NF-kB pathway. These data demonstrated the power of high-throughput in vivo genetic screens for immunotherapy target discovery, and uncovered DHX37 as a functional regulator of CD8+<U+00A0>T cells.","5":"4 biological replicates each of mouse OT-1; Cas9 CD8+ T cells, transduced by AAV6 to express either empty vector or sgDhx37","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315810","14":"[\"CA209992\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion","16":"syn21681881","17":"Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells","18":"[Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells(PMID:31442407)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31442407)","19":"[GEO:GSE132926](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE132926)","_rn_":"82"},{"1":"syn21813792","2":"Systematic identification of immunotherapy targets using genome-scale in vivo CRISPR screens in CD8+ cytotoxic T cells [scRNA-Seq]","3":"PRJNA549582","4":"CD8+<U+00A0>cytotoxic T cells play essential roles in anti-tumor immune responses. Here, we performed in vivo screens in CD8+<U+00A0>T cells and identified regulators of tumor infiltration and killing, which are directly relevant to cancer immunotherapy. Unlike in vitro screens, the in vivo screen robustly re-identified canonical immunotherapy targets such as PD-1 and Tim-3, along with genes that have not been characterized in T cells. The infiltration and degranulation screens converged on an RNA helicase Dhx37. Dhx37 knockout enhanced the efficacy of antigen-specific CD8+<U+00A0>T cells against cancer in vivo. Immunological characterization in mouse and human CD8+<U+00A0>T cells revealed that DHX37 suppresses effector function, cytokine production, and T cell activation. Transcriptomic profiling and biochemical interrogation revealed a role for DHX37 in modulating the NF-kB pathway. These data demonstrated the power of high-throughput in vivo genetic screens for immunotherapy target discovery, and uncovered DHX37 as a functional regulator of CD8+<U+00A0>T cells.","5":"Rag-/- were transplanted with E0771-mCherry-OVA cells. OT-1; Cas9 CD8+ T cells were harvested and transduced with either lenti-Vector or lenti-sgDhx37. Transduced T cells were then adoptively transferred into the tumor-bearing mice. Tumor-infiltrating lymphocytes were subsequently FACS isolated and subject to 10x Genomics single cell RNA-seq.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315810","14":"[\"CA209992\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion","16":"syn21681881","17":"Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells","18":"[Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells(PMID:31442407)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31442407)","19":"[GEO:GSE132959](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE132959), [SRA:SRP201838](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP201838)","_rn_":"83"},{"1":"syn21814110","2":"10X single-cell RNASeq profiling of control or Ptpn2-null P14 CD8+ T-cells from mice chronically infected with LCMV Clone 13","3":"PRJNA554074","4":"5 distinct populations of exhausted CD8+ T cells occur in chronic LCMV Clone 13 infected mice depleted of CD4+ T cells","5":"Single-cell RNA-sequencing based profiling of transferred control or Ptpn2-null P14 CD8+ T-cells from mice chronically infected with LCMV Clone 13 (day 30 post-infection)","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681909","17":"PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity","18":"[PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity(PMID:31527834)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31527834)","19":"[GEO:GSE134139](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134139)","_rn_":"84"},{"1":"syn21814093","2":"ATAC-seq profiling of control or Ptpn2-null P14 CD8+ T-cell subsets from mice chronically infected with LCMV clone 13","3":"PRJNA554959","4":"Chromatin accessibility profiling of CD8+ T cells in chronic LCMV Clone 13 infected mice depleted of CD4+ T cells.","5":"ATAC-seq based profiling of subsets of transferred control or Ptpn2-null P14 CD8+ T-cells from mice chronically infected with LCMV Clone 13 (day 8 post-infection).","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681909","17":"PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity","18":"[PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity(PMID:31527834)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31527834)","19":"[GEO:GSE134385](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134385)","_rn_":"85"},{"1":"syn21814155","2":"Immune effector monocyte - neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer","3":"PRJNA565061","4":"Metastatic behaviour varies significantly among breast cancers. Mechanisms explaining why the majority of breast cancer patients never develop metastatic outgrowth are largely lacking but could underlie the development of novel immunotherapeutic target molecules. Here we show interplay between non-metastatic primary breast cancer and innate immune response, acting together to control metastatic progression. The primary tumor systemically recruits IFN<U+03B3>-producing immune effector monocytes to the lung. IFN<U+03B3> upregulates Tmem173/STING in neutrophils and enhances their killing capacity. The immune effector monocytes and tumoricidal Tmem173/STINGhigh neutrophils target disseminated tumor cells in the lungs, preventing metastatic outgrowth. Importantly, our findings could underlie the development of immunotherapeutic target molecules that augment the function of immune effector monocytes and Tmem173high neutrophils.","5":"The aim is to compare the transcriptome of neutrophils and monocytes CCR2+ purified from lungs of NOD/scid mice bearing the highly metastatic tumors HCl-001 (TN1) and low metastatic tumors HCl-002 (TN2). RNA sequencing was performed on RNA extracted from FACS-sorted monocytes CCR2+ and neutrophils from lungs of mice bearing tumors HCl-001 and HCl-002 reaching end point, followed by purification using an RNeasy Micro Kit (Qiagen). cDNA synthesis and whole, transcriptome amplification was performed using the Smart-seq2 protocol, libraries were prepared using Illumina XT Library Preparation Kit and sequenced by HiSeq 2500 sequencer. Raw reads were aligned to reference transcriptome (Mus_musculus.GRCm38) and transcripts per million values were calculated using Kallisto50 quant, version 0.42.3 (2). AltAnalyze was used to analyze normalized read counts and to calculate differentially expressed genes.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Triple-Negative Breast Cancer Finding\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9774783","14":"[\"CA199315\"]","15":"Integrative approach to heterogeneity in breast cancer metastasis","16":"NA","17":"Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer.","18":"[Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer.(PMID:31591235)(https://www.ncbi.nlm.nih.gov/pubmed/31591235)","19":"[GEO:GSE137300](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137300), [SRA:SRP221410](https://www.ncbi.nlm.nih.gov/sra?term=SRP221410)","_rn_":"86"},{"1":"syn11712137","2":"NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth","3":"PRJNA97217","4":"The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcriptional programs activated by NOTCH1. Using an integrative systems biology approach we show that NOTCH1 controls a feed-forward loop transcriptional network that promotes cell growth. Inhibition of NOTCH1 signaling in T-ALL cells led to a reduction in cell size and elicited a gene expression signature dominated by downregulated biosynthetic pathway genes. By integrating gene expression array and ChIP-on-chip data, we show that NOTCH1 directly activates multiple biosynthetic routes and induces c-MYC gene expression. Reverse engineering of regulatory networks from expression profiles showed that NOTCH1 and c-MYC govern two directly interconnected transcriptional programs containing common target genes that together regulate the growth of primary T-ALL cells. These results identify c-MYC as an essential mediator of NOTCH1 signaling and integrate NOTCH1 activation with oncogenic signaling pathways upstream of c-MYC. Keywords: Drug treatment","5":"Duplicated cultures of T-ALL cell lines were treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h and analyzed using oligonucleotide microarrays. Gene expression changes were analyzed in the context of loss of NOTCH1 signaling induced by the gamma secretase inhibitor treatment.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"T Acute Lymphoblastic Leukemia\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"NA","17":"NA","18":"NA","19":"[GEO:GSE5827](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE5827)","_rn_":"87"},{"1":"syn11510898","2":"mRNA and miRNA Characterization of Cancer Cell Lines","3":"RNA Study - PSON0009","4":"mRNA and miRNA profiling of cell lines.","5":"NA","6":"[\"Whole Transcriptome Sequencing\", \"MicroRNA Sequencing\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"88"},{"1":"syn18425373","2":"Whole-Exome Sequencing of BEZ235-treated cell line hcc1143","3":"exomeSeq","4":"Dataset summary is currently being curated by Sage Bionetworks. Please contact Milen Nikolov at milen.nikolov@sagebase.org if you would like to provide a summary.","5":"NA","6":"[\"Whole Exome Sequencing\"]","7":"[\"Human\"]","8":"[\"Ductal Carcinoma\"]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773345","14":"[\"CA209988\"]","15":"Measuring, Modeling and Controlling Heterogeneity (M2CH)","16":"NA","17":"NA","18":"NA","19":"[SRX3420291](https://www.ncbi.nlm.nih.gov/sra/?term=SRX3420291)","_rn_":"89"},{"1":"syn18425401","2":"Whole Genome Sequencingof HCC1143 breast cancer cells treated with Trametinib, BEZ235, or DMSO","3":"wholeGenomeSeq","4":"Dataset summary is currently being curated by Sage Bionetworks. Please contact Milen Nikolov at milen.nikolov@sagebase.org if you would like to provide a summary.","5":"HCC1143 triple negative breast cancer cells were treated with 1uM Trametinib, 1uM BEZ235, or 0.05% DMSO for 72hr, at which point total DNA was harvested. Replicate samples for each treatment type were entered into whole exome sequencing library prep (detailed in PRJNA419661), and as well were pooled and submitted for low pass whole genome sequencing, detailed here.","6":"[\"Whole Genome Sequencing\"]","7":"[\"Human\"]","8":"[\"Ductal Carcinoma\"]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773345","14":"[\"CA209988\"]","15":"Measuring, Modeling and Controlling Heterogeneity (M2CH)","16":"NA","17":"NA","18":"NA","19":"[SRP144106](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP144106)","_rn_":"90"},{"1":"syn7248581","2":"Genomic (miRNA) Characterization of Cancer Cell Lines","3":"miRNA - PSON0001","4":"miRNA profiling across 39 cell lines.","5":"NA","6":"[\"MicroRNA Sequencing\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"91"},{"1":"syn7248583","2":"Genomic (mRNA) Characterization of Cancer Cell Lines","3":"mRNA - PSON0001","4":"mRNA profiling across 39 cell lines.","5":"NA","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"92"},{"1":"syn7248584","2":"Genomic (Exome) Characterization of Cancer Cell Lines","3":"Exome - PSON0001","4":"Exome profiling across 39 cell lines.","5":"NA","6":"[\"Whole Exome Sequencing\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"93"},{"1":"syn7248585","2":"Atomic Force Microscopy Characterization of Cancer Cell Lines","3":"Atomic Force Microscopy - PSON0002","4":"This study uses atomic force microscopy (AFM) to measure the the deflection of a cantilever upon contact with the cells. 30 cell lines were examined over 7 experimental conditions.","5":"NA","6":"[\"Atomic Force Microscopy\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630078","10":"[\"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"94"},{"1":"syn7248586","2":"Motility Characterization of Cancer Cell Lines","3":"Motility - PSON0003","4":"This study uses images of cells collected using brightfield microscopy at 10x magnification, with ImageJ software used to track motility. 30 cell lines were examined over 7 experimental conditions.","5":"NA","6":"[\"Brightfield Microscopy\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"95"},{"1":"syn7248591","2":"Morphological Characterization of Cancer Cell Lines","3":"Morphology - PSON0004","4":"This study uses images of cells collected using brightfield microscopy at 10x magnification, with ImageJ software used to trace the outline of single cells as well as to report area, circularity and aspect ratio. 30 cell lines were examined over 7 experimental conditions.","5":"NA","6":"[\"Brightfield Microscopy\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"96"},{"1":"syn7248592","2":"Traction Force and Volume Characterization of Cancer Cell Lines","3":"Traction Force and Volume - PSON0005","4":"In this study, live cells were plated on fluorescent beads and fluorescently labeled with CellTracker Green CMFDA (Invitrogen) and DRAQ5 (Cell Signaling Technology) to label cytoplasm and cell nucleus respectively. 28 cell lines were examined.","5":"NA","6":"[\"Traction Force Microscopy\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630078","10":"[\"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"97"},{"1":"syn7843817","2":"Ex vivo Mathematical Myeloma Advisor (EMMA)","3":"MM Project","4":"We investigated the ex vivo response of cancer cells from multiple myeloma patients (newly diagnosed or relapsed).","5":"NA","6":"[\"Colorimetric Cell Viability Assay\"]","7":"[\"Human\"]","8":"[\"Multiple Myeloma\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349753","14":"[\"CA193489\"]","15":"H Lee Moffitt Cancer Center and Research Institute","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"98"},{"1":"syn9639600","2":"Cell Stiffness and Migration Microscopy","3":"Widefield Fluorescence Microscopy","4":"Widefield fluorescence microscopy images of EGFP-actin in U251 human glioblastoma cells cultured on collagen-coated polyacrylamide gels with Young's modulus of 80kPa. Images collected at 1s intervals for a duration of 3 min with an exposure time of 300ms.","5":"NA","6":"[\"Widefield Fluorescence Microscopy\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630079","10":"[\"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349745","14":"[\"CA210190\"]","15":"Center for Modeling Tumor Cell Migration Mechanics","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"99"},{"1":"syn9640483","2":"Cell Stiffness Migration Assay","3":"Migration","4":"Phase contrast microscopy of U251 cells migrating on collagen-coated polyacrylamide gels with Young's modulus of 80kPa. Images are collected every 15 mins for a duration of 16hrs with an exposure time of 100ms.","5":"NA","6":"[\"Microscopy\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630079","10":"[\"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349745","14":"[\"CA210190\"]","15":"Center for Modeling Tumor Cell Migration Mechanics","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"100"},{"1":"syn9641937","2":"Cell Stiffness Migration Force Measurements","3":"Traction Force Microscopy","4":"Image sequences used for traction force estimates of U251 cells cultured on collagen-coated polyacrylamide gels with Young's modulus of 80kPa. Each file contains three images: phase contrast image of the cell, image of fluorescent beads embedded in the gel in the absence of force (cell is detached after trypsin treatment), and fluorescent beads when the cell is applying force to the gel (cell is adhered to gel).","5":"NA","6":"[\"Traction Force Microscopy\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630079","10":"[\"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349745","14":"[\"CA210190\"]","15":"Center for Modeling Tumor Cell Migration Mechanics","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"101"},{"1":"syn9641962","2":"Cell Stiffness Migration Simulation","3":"Cell Migration Simulation","4":"Simulation output from individual iterations of the Cell Migration Simulator code. In the examples here the substrate stiffness is assigned a value of 10kPa and the total number of clutches is 750.","5":"NA","6":"[\"Simulation\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630079","10":"[\"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349745","14":"[\"CA210190\"]","15":"Center for Modeling Tumor Cell Migration Mechanics","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"102"},{"1":"syn9697791","2":"Proteomic Characterization of Cancer Cell Lines","3":"Proteomics - PSON0008","4":"9 cell lines across 7 experimental conditions.","5":"NA","6":"[\"Proteomics Assay\"]","7":"[\"Human\"]","8":"[\"Pan-cancer\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7248578","14":"[]","15":"NA","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"103"},{"1":"syn9961676","2":"Late-stage oncology compound screening of cancer cell lines","3":"Dose-response curve data","4":"Dataset summary is currently being curated by Sage Bionetworks. Please contact Milen Nikolov at milen.nikolov@sagebase.org if you would like to provide a summary.","5":"NA","6":"[\"Colorimetric Cell Viability Assay\"]","7":"[\"Human\", \"Mouse\"]","8":"[\"Pan-cancer\"]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"NA","17":"NA","18":"NA","19":"NA","_rn_":"104"},{"1":"syn21789818","2":"Scalable Microfluidics for Single Cell RNA Printing and Sequencing","3":"PRJNA276634","4":"Single cell transcriptomics has emerged as a powerful approach to dissecting phenotypic heterogeneity in complex, unsynchronized cellular populations. However, many important biological questions demand quantitative analysis of large numbers of individual cells. Hence, new tools are urgently needed for efficient, inexpensive, and parallel manipulation of RNA from individual cells. We report a simple microfluidic platform for trapping single cell lysates in sealed, picoliter microwells capable of <U+201C>printing<U+201D> RNA on glass or capturing RNA on polymer beads. To demonstrate the utility of our system for single cell transcriptomics, we developed a highly scalable technology for genome-wide, single cell RNA-Seq. The current implementation of our device is pipette-operated, profiles hundreds of individual cells in parallel with library preparation costs of ~$0.10-$0.20/cell, and includes five lanes for simultaneous experiments. We anticipate that this system will ultimately serve as a general platform for large-scale single cell transcriptomics, compatible with both imaging and sequencing readouts.!Series_type = Expression profiling by high throughput sequencing","5":"A microfluidic device that pairs sequence-barcoded mRNA capture beads with individual cells was used to barcode cDNA from individual cells which was then pre-amplified by in vitro transcription in a pool and converted into an Illumina RNA-Seq library. Libraries were generated from ~600 individual cells in parallel and extensive analysis was done on 396 cells from the U87 and MCF10a cell lines and from ~500 individual cells with extensive analysis on 247 cells from the U87 and WI-38 cell lines. Sequencing was done on the 3'-end of the transcript molecules. The first read contains cell-identifying barcodes that were present on the capture bead and the second read contains a unique molecular identifier (UMI) barcode, a lane-identifying barcode, and then the sequence of the transcript.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Glioma, Carcinoma in situ of Breast\"]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21645574","17":"Scalable microfluidics for single-cell RNA printing and sequencing","18":"[Scalable microfluidics for single-cell RNA printing and sequencing (PMID:26047807)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26047807)","19":"[GEO:GSE66357](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE66357), [SRA:SRP055569](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP055569)","_rn_":"105"},{"1":"syn21790617","2":"Affymetrix SNP array data for B-lineage acute lymphoblastic leukemia","3":"PRJNA279840","4":"To shed light on the molecular bases of B-lineage acute lymphoblastic leukemia lacking known rearrangements (B-NEG ALL) and the differences between children and adults, we analyzed 168 B-NEG ALLs - including children, adolescents/young adults (AYA) and adults by genome-wide technologies, namely Next-generation sequencing and copy number aberration (CNA). Affymetrix SNP array analysis was performed according to the manufacturer's directions on DNA extracted from bone marrow sampled at diagnosis and paired germline DNA extracted from peripheral blood/bone marrow at complete remission or saliva.","5":"Copy number analysis of Affymetrix SNP 6.0 arrays was performed for 13 B-NEG ALL samples and their paired normal (non-tumoral) DNA samples, included in the discovery panel, processed in the same experiment and deposited.","6":"[\"Single Nucleotide Polymorphism Array\"]","7":"[\"Human\"]","8":"[\"B Acute Lymphoblastic Leukemia\"]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21645570","17":"Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes","18":"[Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes (PMID:26883104)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26883104)","19":"[GEO:GSE67405](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE67405)","_rn_":"106"},{"1":"syn21790254","2":"Reprogrammed myeloid cell transcriptomes in NSCLC","3":"PRJNA283843","4":"Lung cancer is the leading cause of cancer related mortality worldwide, with non-small cell lung cancer (NSCLC) as the most prevalent form. Despite advances in treatment options including minimally invasive surgery, CT-guided radiation, novel chemotherapeutic regimens, and targeted therapeutics, prognosis remains dismal. Therefore, further molecular analysis of NSCLC is necessary to identify novel molecular targets that impact prognosis and the design of new-targeted therapies. In recent years, tumor <U+201C>activated/reprogrammed<U+201D> stromal cells that promote carcinogenesis have emerged as potential therapeutic targets. However, the contribution of stromal cells to NSCLC is poorly understood. Here, we show increased numbers of bone marrow (BM)-derived hematopoietic cells in the tumor parenchyma of NSCLC patients compared with matched adjacent non-neoplastic lung tissue. By sorting specific cellular fractions from lung cancer patients, we compared the transcriptomes of intratumoral myeloid compartments within the tumor bed with their counterparts within adjacent non-neoplastic tissue from NSCLC patients. The RNA sequencing of specific myeloid compartments (immature monocytic myeloid cells and polymorphonuclear neutrophils) identified differentially regulated genes and mRNA isoforms, which were inconspicuous in whole tumor analysis. Genes encoding secreted factors, including osteopontin (OPN), chemokine (C-C motif) ligand 7 (CCL7) and thrombospondin 1 (TSP1) were identified, which enhanced tumorigenic properties of lung cancer cells indicative of their potential as targets for therapy. This study demonstrates that analysis of homogeneous stromal populations isolated directly from fresh clinical specimens can detect important stromal genes of therapeutic value.","5":"We sorted pure populations of the immature monocytic myeloid cells (IMMCs), neutrophils (Neu), and epithelial cells (Epi) from tumors and adjacent lung tissues of stage I-III lung adenocarcinoma patients. RNA samples (totally 17 samples) were sequenced: from tumor IMMC (n=3), Neu (n=2), Epi (n=2); from adjacent lung IMMC (n=3), Neu (n=4), Epi (n=3).","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Lung Non-Small Cell Carcinoma\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775595","14":"[\"CA188388\"]","15":"Modeling and targeting stroma-tumor crosstalk in non small cell lung cancer","16":"syn21681315","17":"Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC","18":"[Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC (PMID:26046767)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26046767)","19":"[GEO:GSE68795](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68795), [SRA:SRP058237](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP058237)","_rn_":"107"},{"1":"syn21811223","2":"Three-dimensional analysis of regulatory features reveals functional enhancer-associated loops","3":"PRJNA283913","4":"To gain insight into the relationship between chromatin structure and gene expression, we conducted a Tethered Chromatin Capture (TCC) analysis using MCF7 breast cancer and PANC1 pancreatic cancer cells. We applied a novel Hi-C analysis algorithm and identified hundreds of thousands of Interacting Loci Pairs (ILPs) in each of the two cell types. We classified ILPs according to location with respect to gene structure, gene expression, different histone modifications, DNase hypersensitivity, and RNA polymerase II and CTCF binding, identifying distinct classes of ILPs. Interestingly, we found that only 5% of the ILPs involved promoter regions, with even fewer promoter-enhancer loops. We find that genes associated with promoter-enhancer loops have cell type-specific functional annotations. We then tested the impact of pharmacological inhibition of histone acetylation on genes having promoter-enhancer ILPs in PANC1 cells. We found that genes with promoter-enhancer ILPs show reduced expression in response to drug treatment, suggesting that the chromatin loops we identified are functional.","5":"We analyzed two datasets, TCC in MCF7 and PANC1 cells. We then correlated them with histone modification data and gene expression data. Anti-CTCF ChIP-Seq was performed on PANC1 cells.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681486","17":"Three-dimensional analysis reveals altered chromatin interaction by enhancer inhibitors harbors TCF7L2-regulated cancer gene signature","18":"[Three-dimensional analysis reveals altered chromatin interaction by enhancer inhibitors harbors TCF7L2-regulated cancer gene signature (PMID:30548288)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30548288)","19":"[GEO:GSE68858](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE68858)","_rn_":"108"},{"1":"syn12976704","2":"A network-based strategy for prioritizing hits from chemical screening data by leveraging genetic, epigenetic and transcriptional datasets","3":"PRJNA289622","4":"Small molecule screens are widely used to prioritize compounds for development of pharmaceuticals and to reveal pathways altered in biological processes. <U+00A0>However, interpreting the results of these screens is very challenging since in almost all cases, the compounds are highly promiscuous. <U+00A0>Here we present a network-based strategy for analyzing molecular screening data. <U+00A0>We report a screen for kinase inhibitors that synergize with gemcitabine, the first-line chemotherapy treatment for pancreatic cancer. <U+00A0>The eight kinase inhibitors that emerge from the screen target a total of 140 kinases, and these kinases show little overlap with previously detected genetic modifiers of gemcitabine toxicity. <U+00A0>Using the SAMNet algorithm, we link the chemical and genetic modifiers of gemcitabine toxicity to transcriptional and epigenetic changes induced by gemcitabine that we measure using DNaseI-Seq and RNA-Seq. SAMNet uses a constrained optimization algorithm to connect genes from these complementary datasets through <U+00A0>a small set of protein-protein and protein-DNA interactions. <U+00A0>The resulting network is able to recapitulate known gemcitabine response pathways including DNA damage repair, control of cellular growth and the EMT pathway. We query the network downstream of putative kinase inhibitor targets and in addition to identifying known gemcitabine synergizers STAT3, NFKB2 and AKT1, we propose novel candidate targets for gemcitabine chemoresistance, including ETS transcription factors (ELK1, ELK3) and the adaptor protein NCK1. Our work suggests that a subset of the <U+201C>off-target kinases<U+201D> are directly involved in the cellular response to gemcitabine by modulating the activity of known and proposed chemosensitizing genes.","5":"4 RNAseq samples and 2 DNaseI-hypersensitivity samples in the PANC1 human cell line","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Pancreatic Ductal Adenocarcinoma\"]","9":"syn21630075","10":"[\"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9772917","14":"[\"CA184898\"]","15":"Embryonal Brain Tumor Networks","16":"syn21645600","17":"Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens","18":"[Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens (PMID:29023490)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29023490)","19":"[GEO:GSE70810](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE70810), [SRA:SRP060702](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP060702)","_rn_":"109"},{"1":"syn21791225","2":"RNA-Seq data for AKT, BAD, ERBB2, IGF1R, RAF1 and ERK1 over-expressed samples with 12 GFP control samples using human mammary epithelial cells","3":"PRJNA297451","4":"The goal was to capture the transcriptional activity due to over-expression of AKT, BAD, ERBB2, IGF1R, RAF1 and ERK1 genes.Over-expressions were validated using Western Blots. Illumina RNA-Seq technology was used to capture the downstream transcriptional activity. Reads were 101 base pairs long and single ended. An R open source package <U+201C>Rsubread<U+201D> was used to align and quantify the read using UCSC hg19 annotation. The integer-based gene counts were later normalized in TPM .","5":"Profiles of gene expression, downstream of AKT, BAD, ERBB2, IGF1R, RAF1 and ERK over-expression, were generated in cells derived from breast and used to generate a gene-expression signatures.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630075, syn21630081, syn21630079","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9771796","14":"[\"CA209978\"]","15":"Cancer Systems Biology Center of HoPE (Heterogeneity of Phenotypic Evolution)","16":"syn21645337","17":"Combating subclonal evolution of resistant cancer phenotypes","18":"[Combating subclonal evolution of resistant cancer phenotypes (PMID:29093439)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29093439)","19":"[GEO:GSE73628](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE73628), [SRA:SRP064353](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP064353)","_rn_":"110"},{"1":"syn12976746","2":"Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells","3":"PRJNA303995","4":"This set of data is for assessing and validation of a novel method, CGI-seq, as described in the corresponding paper, for profiling of single cell CpG methylome. We tested 4 different cell lines (K562, GM12878, 551 K1-iPSC, and Fibroblast ATCC-CCL-110) with a low quantity of cells (LQC, here including 100-cell or 10-cell) and with single cells (SC) separately. Briefly, the protocol include these steps. The intact gDNA of the cell(s) was released. This gDNA (i.e. the TEST sample, but this step was omitted for the Methylation Control or MC sample) was cut with the 1st set of restriction endonucleases, called RE1, which were sensitive to CpG methylation, and distinguished methylated from unmethylated DNA sequences. Then, each sample, including digested TEST DNAs and intact MC DNA, was immediately amplified by MDA method (or REPLIg kit), in which the methylated DNA sequences were highly efficiently amplified, while unmethylated DNA sequences were depleted. The amplicon was then cut with the 2nd set of restriction endonucleases, called RE2, and the appropriate size (between 50-500bp) of fragments were recovered to generate sequencing library, which was to enrich CpG-rich sequences (especially CpG islands) and improve the sequencing efficiency (reduced representation sequencing). Finally, Next Generation Sequencing (NGS) was performed. The outcome sequencing reads were analyzed with a specially designed algorithms. The result shows the high sensitivity, high reliability, high reproduciblity, and high coverage of the method on profiling the genome-wide CpG methylation pattern for single cells. It is a simple, robust and faithful technology for single cell CpG methylation pattern analysis, enabling unsupervised clustering of single cells basing on genome-wide CpG methylation pattern. This method will be valuable to dissect the subpopulation structure for a cellular population heterogeneous in CpG-methylation pattern.","5":"We designed 2 protocols (protocol option 1 - BstUI as RE2, and protocol option2 - ABH as RE2, while other steps were the same) for LQC processing (30 samples with 100Cell or 10cell), and the option 2 above was used for SC (8 samples for K562 and GM12878 separately, totally 16 samples). The corresponding Methylation Controls (MCs, for which no RE1 was applied but all other processes were the same as the TEST) were also generated corresponding to each set of TEST samples. The sequencing data was analyzed, and compared with the published ENCODE data generated with RRBS or Infinium HumanMethylation450 BeadChip methods with bulk cells, for CpG islands, promoters and other informative sequencing fragments. These data were also subject to unsupervised clustering analysis of the cells.","6":"[\"scCGIseq\"]","7":"[\"Human\"]","8":"[\"Chronic myeloid leukemia\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21649212","17":"Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells","18":"[Bisulfite-independent analysis of CpG island methylation enables genome-scale stratification of single cells (PMID:28126923)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28126923)","19":"[GEO:GSE75346](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE75346), [SRA:SRP066615](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP066615)","_rn_":"111"},{"1":"syn21790688","2":"Activation of proto-oncogenes by disruption of chromosome neighborhoods [5C-Seq]","3":"PRJNA309545","4":"Mutations such as gene fusion, translocation and focal amplification are a frequent cause of proto-oncogene activation during tumorigenesis, but such mutations do not explain all cases of proto-oncogene activation. Here we show that disruption of local chromosome conformation can also activate proto-oncogenes in human cells. We mapped chromosome structures in T-cell acute lymphoblastic leukemia (T-ALL), and found that active oncogenes and silent proto-oncogenes generally occur within insulated neighborhoods formed by the looping of two interacting CTCF sites co-occupied by cohesin. Recurrent microdeletions frequently overlap neighborhood boundary sites in T-ALL genomes, and we demonstrate that site-specific perturbation of loop boundaries is sufficient to activate the respective proto-oncogenes in non-malignant cells. We found somatic genomic rearrangements affecting loop boundaries in many cancers. These results suggest that chromosome structural organization is fundamental to identify functional somatic alterations in cancer genomes.","5":"5C analysis of Tal1 and LMO2 in wildtype and mutant HEK293T cells","6":"[\"5C\"]","7":"[\"Human\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645430","17":"Activation of proto-oncogenes by disruption of chromosome neighborhoods","18":"[Activation of proto-oncogenes by disruption of chromosome neighborhoods (PMID:26940867)](https://www.ncbi.nlm.nih.gov/pubmed/?term=26940867)","19":"[GEO:GSE77142](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE77142), [SRA:SRP068783](https://www.ncbi.nlm.nih.gov/sra?term=SRP068783)","_rn_":"112"},{"1":"syn21790736","2":"BET bromodomain proteins Brd2, Brd3 and Brd4 selectively regulate metabolic pathways in the pancreatic <U+03B2>-cell","3":"PRJNA310350","4":"Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored. Small molecule BET inhibitors, such as JQ1, block BET protein binding to acetylated lysines, but lack selectivity within the BET family (Brd2, Brd3, Brd4, Brdt), making it difficult to disentangle contributions of each family member to transcriptional and cellular outcomes. Here, we demonstrate multiple improvements in pancreatic <U+03B2>-cells upon BET inhibition with JQ1 or BET-specific siRNAs. JQ1 (50-400 nM) increases insulin secretion from INS-1 cells in a concentration dependent manner. JQ1 increases insulin content in INS-1 cells, accounting for increased secretion, in both rat and human islets. Higher concentrations of JQ1 decrease intracellular triglyceride stores in INS-1 cells, a result of increased fatty acid oxidation. Specific inhibition of both Brd2 and Brd4 enhances insulin transcription, leading to increased insulin content. Inhibition of Brd2 alone increases fatty acid oxidation. Overlapping yet discrete roles for individual BET proteins in metabolic regulation suggest new isoform-selective BET inhibitors may be useful to treat insulin resistant/diabetic patients. Results imply that cancer and diseases of chronic inflammation or disordered metabolism are related through shared chromatin regulatory mechanisms.","5":"BET proteins are not redundant in their functions, thus pan-BET inhibitors like JQ1 cannot properly be interpreted without specific RNA knockdown or small molecules of proven selectivity. Here, we expose INS-1 cells, a rat insulinoma model for the pancreatic beta cell, to selective siRNAs to ablate Brd2, Brd3 or Brd4 mRNAs and compared genome-wide changes in transcription to non-targeted siRNA control. As expected, three resolvably different patterns of gene expression were identified, establishing that each BET protein controls its own set of target genes.","6":"[\"Expression Array\"]","7":"[\"Rat\"]","8":"[\"Malignant Neoplasm of Pancreas\"]","9":"NA","10":"[]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775665","14":"[\"CA182898\"]","15":"CSBC U01 Project Boston University","16":"syn21648846","17":"BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic <U+03B2>-Cell","18":"[BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic <U+03B2>-Cell (PMID:27008626)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27008626)","19":"[GEO:GSE77450](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE77450)","_rn_":"113"},{"1":"syn21800130","2":"ChIP-seq for H3K27Ac and H3K4me3 in a pre-B-cell model of Acute Lymphoblastic Leukemia, no stimulation or treatment","3":"PRJNA310833","4":"We wanted to identify regions of active and open chromatin in a pre-B-cell model of Acute Lymphoblastic Leukemia (ALL). We did not stimulate or treat the cells, we merely maintained them in culture. We chose these conditions because we were building a computational model and needed a baseline read of histone activation.","5":"For each histone mark, we had one sample where we immunoprecipitated with an antibody for the histone mark of interest and we had one control where we immunoprecipitated with an IgG control.","6":"[\"ChIP-Seq\"]","7":"[\"Mouse\"]","8":"[\"Acute Lymphoblastic Leukemia\"]","9":"syn21630075","10":"[\"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9772917","14":"[\"CA184898\"]","15":"Embryonal Brain Tumor Networks","16":"syn21645592","17":"Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia","18":"[Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia (PMID:27315426)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27315426)","19":"[GEO:GSE77570](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE77570), [SRA:SRP069293](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP069293)","_rn_":"114"},{"1":"syn21790756","2":"A highly sensitive and robust method for genome-wide 5hmC profiling of rare cell populations","3":"PRJNA312218","4":"Investigations of 5-hydroxymethylcytosine (5hmC) in biologically and clinically samples and models with low cell numbers have been hampered by the low sensitivity and reproducibility using current 5hmC mapping approaches. Here, we develop a selective 5hmC chemical labeling approach using tagmentation-based library preparation in order to profile nanogram levels of 5hmC isolated from ~1,000 cells (nano-hmC-Seal). Using this technology, we profiled the dynamics of 5hmC across different stages of mouse hematopoietic differentiation. Additionally, applying nano-hmC-Seal to the hematopoietic multipotent progenitor cells in an acute myeloid leukemia (AML) mouse model, we identified leukemia-specific, differentially hydroxymethylated regions that harbor previously reported and as-yet-unidentified functionally relevant factors. The change of 5hmC patterns in AML strongly correlates with the altered gene expression on a global scale. Together, our new approach offers a highly sensitive and robust method to study and detect DNA methylation dynamics from in vivo model and clinical samples.","5":"Selective 5hmC chemical labeling approach using tagmentation-based library preparation in order to profile nanogram levels of 5hmC isolated from ~1,000 cells","6":"[\"Nano-hmC-Seal\", \"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645405","17":"A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations","18":"[A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations (PMID:27477909)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27477909)","19":"[GEO:GSE77967](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE77967), [SRA:SRP070188](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP070188)","_rn_":"115"},{"1":"syn21790743","2":"Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells","3":"PRJNA312393","4":"We describe a protocol for freezing neuronal cells that is compatible with ATAC-Seq, producing results that compare well with those generated from fresh cells. We developed our protocol on a disease-relevant cell type, namely motor neurons differentiated from induced pluripotent stem cells from a patient affected by spinal muscular atrophy. We found that while flash-frozen motor neurons are not suitable for ATAC-Seq, the assay is successful with slow-cooled cryopreserved samples. Using this method, we were able to isolate high quality, intact nuclei, and we verified that epigenetic results from fresh and cryopreserved motor neurons agree quantitatively.","5":"We quantitatively compare the results from fresh and cryopreserved motor neurons. We generated sequencing data on three technical replicates from both conditions.Submitter declares that reads for the transposed naked DNA used as a control will be made available through dbGaP.","6":"[\"ATAC-Seq\"]","7":"[\"Human\"]","8":"[]","9":"syn21630075","10":"[\"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9772917","14":"[\"CA184898\"]","15":"Embryonal Brain Tumor Networks","16":"syn21645594","17":"Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells","18":"[Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells (PMID:27146274)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27146274)","19":"[GEO:GSE78036](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78036), [SRA:SRP070460](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP070460)","_rn_":"116"},{"1":"syn21792857","2":"Hela cell line microRNA profiles following CFIm25 knockdown","3":"PRJNA312905","4":"Purpose: When CFIm25 knockdown induces global APA events, we aim to investigate ceRNA landscape change based on microRNA expression change. Methods: microRNA from HeLa cells treated with control siRNA and CFIm25 siRNA were subject to RNA-Seq. Results: Consistent with our observations in TCGA breast cancer, we found a surprisingly high enrichment of 3<U+02B9>UTR shortening genes' ceRNA partners to tumor suppressors and their down-regulation. Conclusion: Our work indicated that the shortened 3<U+02B9>-UTRs might direct the released miRNAs to repress their ceRNA partners in trans, which are enriched in ceRNET hubs and tumor suppressors, thereby effectively disrupting normal ceRNET and contributing to tumorigenesis.","5":"Hela cell line microRNA profiles of control treated and CFIm25 knockdown were generated by RNA-Seq using Illumina GAIIx.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681375","17":"3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk","18":"[3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk (PMID:29785014)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29785014)","19":"[GEO:GSE78198](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78198), [SRA:SRP070693](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP070693)","_rn_":"117"},{"1":"syn21809435","2":"RNA Methyltransferase METTL14 Promotes Breast Cancer Growth and Progression","3":"PRJNA320762","4":"We investigated the role of RNA N6-adenosine methyltransferase protein METTL14 that supports breast cancer growth and progression, and we showed METTL14 knockdown inhibited long-term survival, migration as well as invasion of breast cancer cells.","5":"To understand the mechanism by which METTL14 may promote breast cancer growth, we performed RNA-seq analyses on METTL14 siRNA-transfected breast cancer cells (2x MDA-MB-231), comparing to cells transfected with scramble siRNAs (2 replicates). Interestingly, several genes known to be associated with oncogenic pathways were found to be significantly altered in METTL14-silenced breast cancer cells, including transforming growth factor beta1 (TGF<U+03B2>1), smad3, cyclin D1 and cyclin E1.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681435","17":"Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression","18":"[Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression (PMID:30306128)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30306128)","19":"[GEO:GSE81164](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE81164), [SRA:SRP074429](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP074429)","_rn_":"118"},{"1":"syn21790831","2":"Chemical Mapping Reveals Novel Features of The Nucleosome Landscape in Mouse Embryonic Stem Cells<U+00A0>","3":"PRJNA324099","4":"Nucleosome organization influences gene activity by controlling DNA accessibility to transcription machinery. Here, we develop a chemical biology approach to determine mammalian nucleosome positions genome-wide. Using this strategy, we uncover surprising new features of nucleosome organization in mouse embryonic stem cells. In contrast to the prevailing model, we observe that for nearly all mouse genes a class of fragile nucleosomes occupies previously designated nucleosome-depleted regions around transcription start sites and transcription termination sites. We show that a subset of DNA-binding proteins including insulator CTCF and pluripotency factors co-occupy DNA targets with nucleosomes. Furthermore, we provide in vivo evidence that promoter-proximal nucleosomes, with the +1 nucleosome in particular, contribute to the pausing of RNA Polymerase II. Lastly, we find a characteristic preference for nucleosomes at exon-intron junctions. Altogether, we establish an accurate method for defining the nucleosome landscape, and provide a valuable resource for studying nucleosome-mediated gene regulation in mammalian cells.","5":"5 samples total. Chemical sample was analyzed with high throughput paired-end parallel sequencing. MNase samples were analyzed with high throughput paired-end parallel sequencing. 4 RNA samples from mouse ES cells (H4S47C Chemical vs WT) treated with 2i or Lif culture conditions.","6":"[\"Whole Transcriptome Sequencing\", \"MNase-seq\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645389","17":"Insights into Nucleosome Organization in Mouse Embryonic Stem Cells through Chemical Mapping","18":"[Insights into Nucleosome Organization in Mouse Embryonic Stem Cells through Chemical Mapping (PMID:27889238)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27889238)","19":"[GEO:GSE82127](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE82127), [SRA:SRP075973](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP075973)","_rn_":"119"},{"1":"syn21790882","2":"RNA-Seq data for AKT, BAD, ERBB2, IGF1R, RAF1 and KRAS(G12V) overexpressed samples with 12 GFP control samples using human mammary epithelial cells","3":"PRJNA324703","4":"The goal was to capture the transcriptional activity due to over-expression of AKT, BAD, ERBB2, IGF1R, RAF1 and KRAS(G12V) genes .Overexpressions were validated using Western Blots. Illumina RNA-Seq technology was used to capture the downstream transcriptional activity. Reads were 101 base pairs long and single ended. An R open source package <U+201C>Rsubread<U+201D> was used to align and quantify the read using UCSC hg19 annotation. The integer-based gene counts were later normalized in TPM .","5":"Profiles of gene expression, downstream of AKT, BAD, ERBB2, IGF1R, RAF1 and KRAS(G12V) over-expression, were generated in cells derived from breast and used to generate a gene-expression signatures.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630075, syn21630081, syn21630079","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9771796","14":"[\"CA209978\"]","15":"Cancer Systems Biology Center of HoPE (Heterogeneity of Phenotypic Evolution)","16":"syn21648903","17":"Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes","18":"[Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes (PMID:28446242)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28446242)","19":"[GEO:GSE83083](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE83083), [SRA:SRP076235](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP076235)","_rn_":"120"},{"1":"syn21828913","2":"A computational systems approach for identification of synergistic specification genes facilitates lineage conversion to prostate tissue","3":"PRJNA325519","4":"We report that a computational systems approach can identify cell type specification genes that act synergistically, and demonstrate its application for reprogramming of fibroblasts to prostate tissue. We have employed three such master regulators (FOXA1, NKX3.1, and androgen receptor, AR) in a primed conversion strategy to generate prostate tissue from mouse fibroblasts, involving expression of pluripotency factors, tissue recombination with embryonic urogenital mesenchyme, and renal grafting.","5":"RNA-sequencing profiles of prostate tissues and fibroblasts were generated and compared to RNA-sequencing profiles of induced prostate tissue in tissue recombinants.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21645325","17":"A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue","18":"[A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue (PMID:28429718)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28429718)","19":"[GEO:GSE83298](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE83298), [SRA:SRP076484](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP076484)","_rn_":"121"},{"1":"syn21790751","2":"Transcriptome profiling of self-renewing hESCs and multipotent mesoderm progenitor cells as a function of substrate stiffness","3":"PRJNA326429","4":"We performed RNA-sequencing on human embryonic stem cell samples grown on soft (400Pa) and stiff (60kPa) hydrogels under self-renewal and differentiation conditions","5":"Whole-transcriptome RNA sequencing in the conditions described","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7416710","14":"[\"CA202241\"]","15":"ECM geometrical and mechanical properties modulate RTK signaling","16":"syn21649111","17":"Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation","18":"[Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation (PMID:27452175)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27452175)","19":"[GEO:GSE83584](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE83584), [SRA:SRP076871](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP076871)","_rn_":"122"},{"1":"syn12976748","2":"mTOR and HDAC inhibitors converge on the TXNIP/thioredoxin pathway to cause catastrophic oxidative stress and regression of RAS-driven tumors","3":"PRJNA328279","4":"mTOR and HDAC inhibitors induce cell death of malignant peripheral nerve sheath tumors (MPNSTs) in vitro, and in vivo We performed microarray analysis of mTOR and HDAC inhibition alone and in combination 24 hours after treatment, prior to induction of cell death, to identify transcriptional changes that might be mechanistic drivers of the therapeutic efficacy","5":"12 samples, in triplicate, 3X vehicle, 3X INK-128, 3X Vorinostat, 3X INK-128 + Vorinostat","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"Malignant Peripheral Nerve Sheath Tumors\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21649213","17":"mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors","18":"[mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors (PMID:28963352)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28963352)","19":"[GEO:GSE84205](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE84205)","_rn_":"123"},{"1":"syn21792538","2":"Gene expression data from primary neuroblastoma tumors","3":"PRJNA336020","4":"This dataset contains gene expression data from the NRC series (Neuroblastoma Research Consortium) for a total of 283 primary neuroblastoma tumors. All tumor samples are fully annotated including patient age at diagnosis, overall and progresison free survival and MYCN amplification status, enabling subgroup analysis, survival analysis and gene expression network analysis.","5":"283 primary untreated neuroblastoma tumors were analyzed. No replicates were included.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"Neuroblastoma\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21648926","17":"Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma","18":"[Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma (PMID:29510988)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29510988)","19":"[GEO:GSE85047](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85047)","_rn_":"124"},{"1":"syn21791250","2":"Transcriptional profiling of GDF11 or TGFB1 stimulated NMuMG 3D spheroids","3":"PRJNA336578","4":"The objective of this study was to identify transcriptional changes differentially regulated by GDF11 stimulation compared to TGFB1 Microarrays were used to capture the differential transcriptional response to acute GDF11 stimulation compared to acute TGFB1 stimulation","5":"NMuMG 3D spheroids were stimulated with 250 ng/mL GDF11, 50 ng/mL TGFB1, or serum-free media and evaluated at four hours after stimulation in biological quadruplicate.","6":"[\"Expression Array\"]","7":"[\"Mouse\"]","8":"[\"Triple-Negative Breast Cancer Finding\"]","9":"syn21630075, syn21630081","10":"[\"Heterogeneity\", \"Evolution\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084062","14":"[\"CA215794\"]","15":"An Integrated Systems Approach for Incompletely Penetrant Onco-phenotypes","16":"syn21649000","17":"Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer","18":"[Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer (PMID:29161592)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29161592)","19":"[GEO:GSE85224](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85224), [SRA:SRP081446](https://www.ncbi.nlm.nih.gov/sra?term=SRP081446)","_rn_":"125"},{"1":"syn12976694","2":"Immune escape in breast cancer during in situ to invasive carcinoma transition","3":"PRJNA345006","4":"To dissect mechanisms of immune escape during breast tumor progression, we analyzed the composition of leukocytes in normal breast tissues, ductal carcinomas in situ (DCIS), and HER2+ and triple negative invasive ductal carcinomas (IDC). We found significant tissue and tumor subtype-specific differences in multiple cell types including T cells and neutrophils. Analysis of gene expression profiles of T cells demonstrated enrichment for activated GZMB+MKI67+CD8+ effector T cell signatures in DCIS. TCR clonotypes also showed highest diversity in DCIS. Na<U+00EF>ve T cell signatures predominated IDCs, especially triple negative subtypes. TIGIT and PDL1 immune checkpoint proteins showed differential expression between DCIS and IDCs with amplification of CD274 (encoding PDL1) only detected in triple negative IDCs. Our results imply that DCIS progression is limited by an anti-tumor immune response that becomes muted in invasive tumors due to selection for cancer cells and microenvironment that suppress activated T cells or no longer trigger their activation.","5":"RNA-Seq: Gene expression analyses in leukocytes sorted from normal breast tissues, ductal carcinomas in situ (DCIS), and HER2+ and triple negative invasive ductal carcinomas (IDC).","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Invasive Ductal Breast Carcinoma\", \"Intraductal Carcinoma in situ of Breast\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21649209","17":"Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition","18":"[Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition (PMID:28652380)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28652380)","19":"[GEO:GSE87517](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE87517), [SRA:SRP090689](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP090689)","_rn_":"126"},{"1":"syn12576666","2":"DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients","3":"PRJNA350299","4":"Early postnatal exposures to Bisphenol A (BPA) and genistein (GEN) have been reported to predispose for and against mammary cancer, respectively, in adult rats. Since the changes in cancer susceptibility occurs in the absence of the original chemical exposure, we have investigated the potential of epigenetics to account for these changes. DNA methylation studies reveal that prepubertal BPA exposure alters signaling pathways that contribute to carcinogenesis. Prepubertal exposure to GEN and to BPA + GEN suggests pathways involved in maintenance of cellular function, indicating that the presence of GEN either reduces or counters some of the alterations caused by the carcinogenic properties of BPA. We subsequently evaluated the potential of epigenetic changes in the rat mammary tissues to predict survival in breast cancer patients via The Cancer Genomic Atlas (TCGA). We identified 12 genes that showed strong predictive values for long-term survival in estrogen receptor positive patients. Importantly, two genes associated with improved long term survival, HPSE and RPS9, were identified to be hypomethylated in mammary glands of rats exposed prepuberally to GEN or to GEN + BPA respectively, reinforcing the suggested cancer suppressive properties of GEN.","5":"We conducted MBDCap-seq on mammary glands procured from 100 day-old rats exposed prepubertally to vehicle control, BPA, GEN, or BPA + GEN (n = 5/ group)","6":"[\"Methylation Profiling by Array\"]","7":"[\"Rat\"]","8":"[\"Ductal Carcinoma\"]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21645258","17":"DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients","18":"[DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients (PMID:28505145)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28505145)","19":"[GEO:GSE89107](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89107), [SRA:SRP091986](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP091986)","_rn_":"127"},{"1":"syn21790813","2":"Regulatory T cells exhibit distinct features in human breast cancer","3":"PRJNA350777","4":"The goal of this study is to compare transcriptional profiles of regulatory T cells and conventional CD4 T cells in human breast cancer to regulatory T cells and conventional CD4 T cells in normal breast parenchyma and in peripheral blood.","5":"RNA sequencing of 2 different cell types in 3 different tissues","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21645339","17":"Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer","18":"[Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer (PMID:27851913)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27851913)","19":"[GEO:GSE89225](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89225), [SRA:SRP092158](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP092158)","_rn_":"128"},{"1":"syn21832111","2":"Epigenetic analysis of tumor-specific CD8 T cells in murine and solid tumors","3":"PRJNA351717","4":"ATACseq analysis of dysfunctional CD8 T cells in progressing tumors. The overall goal of this study was to elucidate chromatin states associated with functional unresponsiveness in tumor-specific CD8 T cells in the context of mouse and human tumors. As comparison we also investigated chromatin state dynamics associated with CD8 T cells differentiation to functional effector and memory T cells during an acute listeria infection.","5":"CD8 T cells were sorted by flow cytometry and ATAC-seq was performed.","6":"[]","7":"[\"Mouse\", \"Human\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21645338","17":"Chromatin states define tumour-specific T cell dysfunction and reprogramming","18":"[Chromatin states define tumour-specific T cell dysfunction and reprogramming (PMID:28514453)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28514453)","19":"[GEO:GSE89308](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89308)","_rn_":"129"},{"1":"syn21832136","2":"Transcriptome analysis of tumor-specific CD8 T cells in murine solid tumors","3":"PRJNA351718","4":"RNAseq analysis of CD8 T cells becoming dysfunctional in progressing tumors. The overall goal of this study was to elucidate the molecular program that mediates functional unresponsiveness in tumor-specific CD8 T cells. In comparison, we also investigated CD8 T cells differentiating to functional effector and memory T cells during an acute listeria infection.","5":"T cells were sorted by flow cytometry and RNA-seq was performed.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21645338","17":"Chromatin states define tumour-specific T cell dysfunction and reprogramming","18":"[Chromatin states define tumour-specific T cell dysfunction and reprogramming (PMID:28514453)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28514453)","19":"[GEO:GSE89307](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE89307), [SRA:SRP092280](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP092280)","_rn_":"130"},{"1":"syn12976729","2":"Nm-seq finds thousands of modified 2<U+2019>-O-methylation sites in mRNA with base precision","3":"PRJNA354610","4":"Nm-seq maps 2'-O-methylation sites in human mRNA with base precision The ribose of rna nucleotides can be 2<U+2032>-O-methylated (nm). despite advances in high-throughput detection, the inert chemical nature of nm still limits sensitivity and precludes mapping in mrna. We leveraged the differential reactivity of 2<U+2032>-O-methylated and 2<U+2032>-hydroxylated nucleosides to periodate oxidation to develop nm-seq, a sensitive method for transcriptome-wide mapping of nm with base precision. nm-seq uncovered thousands of nm sites in human mrna with features suggesting functional roles.","5":"we developed a conceptually distinct approach based on the different chemical properties of nucleosides with 2<U+2032>-OH and 2<U+2032>-OMe22<U+2013>25, combining enrichment with detection of a positive signal (rather than the lack of signal) to produce a sensitive method suited for discovery of Nm sites in rare RNA molecules or at low stoichiometry. Nm-seq leverages oxidative cleavage of ribose 2<U+2032>,3<U+2032>-vicinal diols by periodate to expose, enrich and map Nm sites in the transcriptome without bias and with single-nucleotide precision.Nm-seq first exposes internal Nm sites in RNA fragments by iterative oxidation<U+2013>elimination<U+2013>dephosphorylation (OED) cycles that remove 2<U+2032>-unmodified nucleotides (one per cycle) in the 3<U+2032>-to-5<U+2032> direction.","6":"[\"Nm-seq\"]","7":"[\"Human\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645423","17":"Nm-seq maps 2'-O-methylation sites in human mRNA with base precision","18":"[Nm-seq maps 2'-O-methylation sites in human mRNA with base precision (PMID:28504680)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28504680)","19":"[GEO:GSE90164](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90164), [SRA:SRP093757](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP093757)","_rn_":"131"},{"1":"syn21797950","2":"Pan-Cancer DNA Hypermethylation Leads to Transcriptional Upregulation of Homeobox Oncogene","3":"PRJNA355884","4":"Cancers have long been recognized to be not only genetically but also epigenetically distinct from their tissues of origin. Although genetic alterations underlying oncogene upregulation have been well studied, to what extent epigenetic mechanisms, such as DNA methylation, can also induce oncogene expression remains unknown. Here, through pan-cancer analysis of 4,182 genome-wide profiles, including whole-genome bisulfite sequencing (WGBS) data from 30 normal tissues and 35 solid tumors, we discovered a strong correlation between gene-body hypermethylation of DNA methylation canyons (broad under-methylated regions) and overexpression of ~43% homeobox genes, many of which are also oncogenes. To gain insights into the cause-and-effect relationship, we used a newly developed dCas9-SunTag-DNMT3A system to methylate genomic sites of interest. The locus-specific hypermethylation of gene-body canyon, but not promoter, of homeobox oncogene DLX1 and POU3F3, can direct increase its gene expression. Together, our pan-cancer analysis followed by functional validation reveals DNA hypermethylation as a novel epigenetic mechanism for homeobox oncogene upregulation.","5":"Locus-specific DNA methylation of DLX1 and POU3F3 gene-bodies was conducted using our dCas9-SunTag-DNMT3A system. In brief, doxycycline-inducible lentiviral particles of dCas9-SunTag-p2A-BFP and scFv-sfGFP-DNMT3A were transduced in human embryonic kidney cell line (HEK293T). The Single clones of idCas9SunTag, idCas9SunTag+iscFvDNMT3A and idCas9SunTag+iscFvDNMT3AE756A was purified. Lentiviral particles of sgDLX1+sgPOU3F3-puromycin and sgPOU3F3-puromycin were also generated and transduced in previously generated inducible dCas9-SunTag-DNMT3A cells. Transduced cells were treated with 2<U+03BC>g/ml puromycin for seven consecutive days and cultured in 2<U+03BC>g/ml doxycycline for another thirty days. SgRNA primers were listed as following: DLX1-F 5<U+2019>-CACCGGGCGGACTCGGAGAAGAGCA-3<U+2019>, DLX1-R 5<U+2019>-AAACTGCTCTTCTC CGAGTCCGCCC-3<U+2019>, POU3F3-F: 5<U+2019>-CACCGCGGCGGCGGGGGCGGCGCAG-3<U+2019>, POU3F3-R: 5<U+2019> -AAACCTGCGCCGCCCCCGCCGCCGC-3<U+2019>. Bisulfite sequencing to identify the loci DNA methylation changes in homeobox gene DLX1 and POU3F3 promoter and gene body using Illumina HiSeq 2000","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21648978","17":"Homeobox oncogene activation by pan-cancer DNA hypermethylation","18":"[Homeobox oncogene activation by pan-cancer DNA hypermethylation (PMID:30097071)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30097071)","19":"[GEO:GSE90780](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90780), [SRA:SRP094446](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP094446)","_rn_":"132"},{"1":"syn21790851","2":"Transdifferentiation as a mechanism of treatment resistance in a mouse model of castration-resistant prostate cancer","3":"PRJNA358422","4":"Analysis of transcriptome of prostate tissue from the anterior lobe or tumor from 9, 12, 13, 14, and 16 months old mouse Prostate tissue or tumor from 9 month old Nkx3.1CreERT2/+ mice, 14 month old Nkx3.1CreERT2/+;Ptenflox/flox mice (intact, treated with vehicle), 16 month old Nkx3.1CreERT2/+;Ptenflox/flox mice (castrated, treated with vehicle or abiraterone), 12 month old Nkx3.1CreERT2/+;Ptenflox/flox;P53flox/flox mice(intact, treated with vehicle), 13 month old Nkx3.1CreERT2/+;Ptenflox/flox;P53flox/flox mice (castrated, treated with vehicle or abiraterone) was harvested, and snap frozen for subsequent molecular analysis","5":"Total RNA obtained from prostate tissues or tumors. Prostate tissues or tumors were harvested and processed for RNA isolation and transcriptome analysis using the MagMAX RNA isolation kit (Ambion).","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Carcinoma in situ of prostate\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21645319","17":"Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer","18":"[Transdifferentiation as a Mechanism of Treatment Resistance in a Mouse Model of Castration-Resistant Prostate Cancer (PMID:28411207)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28411207)","19":"[GEO:GSE92721](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE92721), [SRA:SRP095488](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP095488)","_rn_":"133"},{"1":"syn21791536","2":"Gene expression from laser capture microdissected pancreatic cancer epithelium and stroma","3":"PRJNA360619","4":"This study used laser capture microdissection to obtain paired tumor epithelium and stroma RNA samples from human pancreatic ductal adenocarcinoma (PDA) frozen sections. Libraries were prepared using the Nugen Ovation RNA-Seq System V2 and sequenced to a depth of 30 million 100bp single-end reads. These data were used to model compartment-specific gene expression density on a genome-wide scale and build an algorithm for transcriptional devonvolution (ADVOCATE). RNA sequencing of macrodissected bulk PDA sections was performed on 15 samples in order to systematically compare TruSeq and NuGEN RNA-Seq libraries and (ii) correlate histopathological and molecular assessment of tumor composition.","5":"Gene expression data are presented for 65 pairs of tumor epithelium and stroma LCM samples and 15 bulk tumors using NuGEN and TruSeq library preparation, respectively.\\nGene expression data are presented for 57 additional tumor stromas.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Pancreatic Ductal Adenocarcinoma\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21681523","17":"Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes","18":"[Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes (PMID:30658994)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30658994)","19":"[GEO:GSE93326](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE93326), [SRA:SRP096338](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP096338)","_rn_":"134"},{"1":"syn12976504","2":"Metabolic origins of spatial organization in the tumor microenvironment","3":"PRJNA361582","4":"We report the transcriptional changes induced by hypoxia and/or lactate on bone marrow-derived macrophages (BMDMs)","5":"Untreated macrophages as well as macrophages treated with lactate, cultured in hypoxia (1% oxygen) or both were cultured in vitro. Then total mRNA was sequenced.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21649207","17":"Metabolic origins of spatial organization in the tumor microenvironment","18":"[Metabolic origins of spatial organization in the tumor microenvironment (PMID:28246332)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28246332)","19":"[GEO:GSE93702](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE93702), [SRA:SRP096883](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP096883)","_rn_":"135"},{"1":"syn21797590","2":"A de novo mouse model of C11orf95-RELA fusion-driven ependymoma identifies driver functions in addition to NF<U+03BA>B","3":"PRJNA362328","4":"The vast majority of supratentorial ependymomas (ST-EPNs) have few mutations other than chromosomal rearrangements on chromosome 11, most generating a fusion between C11orf95 and RELA (CR). This CR fusion can transform stem cells ex vivo rendering them oncogenic and may possess NF-<U+03BA>B activity, which has been proposed to be a mechanism of oncogenesis. However, it is not known whether CR is sufficient for EPN formation in vivo, and from what cell type and location. We found that CR is sufficient to form tumors from cells in the ependymal zone in mice that show many molecular and histologic similarities to human ST-EPN. Furthermore, the activation of NF-<U+03BA>B by this fusion protein appears minimal and not related to its oncogenic activity","5":"C11orf95-RELA is a potent oncogene for supratentorial ependymoma","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Glioma\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21648963","17":"A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-<U+03BA>B","18":"[A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-<U+03BA>B (PMID:29949764)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29949764)","19":"[GEO:GSE93765](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE93765), [SRA:SRP096964](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP096964)","_rn_":"136"},{"1":"syn12685522","2":"Applied topology delineates developmental progression with single-cell resolution","3":"PRJNA374716","4":"Cellular lineage commitment and terminal cellular differentiation result from the induction of dynamically regulated transcriptional programs. We report an unbiased approach to studying this process that combines temporal single cell RNA-sequencing and topology-based computational analyses (single cell Topological Data Analysis (scTDA)). scTDA is a non-linear, model-independent, statistical framework particularly tailored to capture high-dimensional continuous relationships, allowing for unsupervised characterization of transient cellular states. We analyzed single-cell RNA-seq data from murine embryonic stem cells (mESCs) as they differentiate in vitro in response to inducers of motor neuron differentiation. scTDA resolved asynchrony and continuity in cellular identity over time, and identified four transient states (pluripotent, precursor, progenitor, and fully differentiated cells) based on dynamic changes in stage-dependent combinations of transcription factors, RNA-binding proteins and long non-coding RNAs. scTDA is applicable to a broad range of problems that involve asynchronous or stochastic cellular responses to developmental cues or environmental perturbations.","5":"Single cell RNA sequencing of 2,744 individual cells, spanning 2 biological (non-technical) replicates. Cells were sampled daily across days 2 through 6 of the in vitro differentiation of mESCs into motor neurons.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21645558","17":"Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development","18":"[Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development (PMID:28459448)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28459448)","19":"[GEO:GSE94883](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94883), [SRA:SRP099648](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP099648)","_rn_":"137"},{"1":"syn9630031","2":"Shifting the optimal stiffness for cell migration","3":"PRJNA377905","4":"Cell migration is central to many biological processes including embryonic development, wound healing, and cancer progression. Cell migration is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum at which migration is maximal. Here we present a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the number of active molecular motors and clutches. This prediction is verified experimentally by comparing cell traction and F-actin retrograde flow for two cell types with differing amounts of active motors and clutches: embryonic chick forebrain neurons (ECFNs; optimum ~1 kPa) and U251 glioma cells (optimum ~100 kPa). In addition, the model predicts, and experiments confirm, that the stiffness optimum of U251 glioma cell migration, morphology, and F-actin retrograde flow rate can be shifted to lower stiffness by simultaneous drug inhibition of myosin II motors and integrin-mediated adhesions.","5":"To collect enough mRNA for expression analysis on different stiffnesses, U251 cells were cultured on large polyacrylamide gels covering the surface of a one well chamber glass slide (Lab-Tek 154453). After one day of culture on the gels, mRNA was purified from the cells using an RNeasy Mini Kit (Qiagen 74104). mRNA samples were then analyzed at the University of Minnesota Genomics Center using a HumanHT-12 BeadChip microarray (Illumina BD 103-0204). mRNA was collected from three U251 glioma cultures each on 4.6, 20, and 200 kPa PAGs, as well as plastic for a total of 12 mRNA samples. mRNA counts from the BeadChip were compared to a published list8 of cell migration genes to identify the most likely contributors to the motor-clutch model in U251 glioma cells (Extended Data Table 1). The expression levels on the different stiffnesses were compared to each other to identify any significant expression differences among the stiffnesses.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630078, syn21630079, syn21630077","10":"[\"Microenvironment\", \"Metastasis\", \"Tumor-Immune\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349745","14":"[\"CA210190\"]","15":"Center for Modeling Tumor Cell Migration Mechanics","16":"syn21645266","17":"Shifting the optimal stiffness for cell migration","18":"[Shifting the optimal stiffness for cell migration (PMID:28530245)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28530245)","19":"[GEO:GSE95680](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE95680)","_rn_":"138"},{"1":"syn12976725","2":"protein levels in BRAF/MEK inhibitor resistance melanoma cells treated with PF3758309 [CR]","3":"PRJNA380061","4":"3 BRAF/MEK inhibitor resistance melanoma cells were treated with PAK inhibitor PF3758309 for 48 hr, the cell lysis were analyzed by RPPA profiling by protein array (RPPA)","5":"3 pair of samples were analyzed (control and PF3758309 treatment group) by RPPA, more than 200 of proteins were tested","6":"[\"RPPA\"]","7":"[\"Human\"]","8":"[\"Melanoma\"]","9":"syn21630078, syn21630081, syn21630079","10":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349747","14":"[\"CA193417\"]","15":"Physical Science Oncology Center at Penn","16":"syn21649211","17":"PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas","18":"[PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas (PMID:28953887)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28953887)","19":"[GEO:GSE96902](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96902)","_rn_":"139"},{"1":"syn12976490","2":"Mutant IDH1 regulates the tumor-associated immune system in gliomas","3":"PRJNA380261","4":"Gliomas harboring mutations in isocitrate dehydrogenase 1/2 (IDH1/2) have the CpG island methylator phenotype (CIMP) and significantly longer patient survival time than wild-type IDH1/2 tumors. Although there are many factors underlying the differences in survival between these two tumor types, immune-related differences in cell content are potentially important contributors. In order to investigate the role of IDH mutations in immune response, we created a syngeneic pair mouse model for mutated IDH1 (mutIDH1) and wild-type IDH1 (wtIDH1) gliomas and demonstrated that muIDH1 mice showed many molecular and clinical similarities to muIDH1 human gliomas, including a 100-fold higher concentration of 2-hydroxygluratate (2-HG), longer survival time, and higher CpG methylation compared to wtIDH1. Also, we showed that IDH1 mutations caused downregulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system. Given that significant infiltration of immune cells such as macrophages, microglia, monocytes, and neutrophils is linked to poor prognosis in many cancer types, these reduced immune infiltrates in muIDH1 glioma tumors may contribute in part to the differences in aggressiveness of the two glioma types.","5":"Ntva_Ink4a/Arf-/- mice were used to generate mouse gliomas. The genetic backgrounds of tva mice are FVB/N, C57BL6, BALB/C, and 129. To generate wtIDH1- and muIDH1-expressing mouse gliomas, we used the RCAS/tva system as described previously. PDGFa-expressing DF1 cells were mixed with either wtIDH1-shp53- or muIDH1-shp53-expressing DF1 cells. These mixed DF1 cells were injected into Ntva_ Ink4a/Arf-/- mice. Mice were monitored daily until they developed signs of illness, such as lethargy, poor grooming, weight loss, dehydration, macrocephaly, seizure, jumping, and/or paralysis. Whole tumor tissue was used for RNA extraction. Total RNA was extracted from tumor tissues using RNeasy Mini kits (QIAGEN).","6":"[\"Expression Array\"]","7":"[\"Mouse\"]","8":"[\"Glioma\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21648867","17":"Mutant IDH1 regulates the tumor-associated immune system in gliomas","18":"[Mutant IDH1 regulates the tumor-associated immune system in gliomas (PMID:28465358)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28465358)","19":"[GEO:GSE96979](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96979)","_rn_":"140"},{"1":"syn21791111","2":"PLATE-Seq for Genome-Wide Regulatory Network Analysis of High-Throughput Screens","3":"PRJNA381890","4":"Pharmacological and functional genomic screens play an essential role in the discovery and characterization of therapeutic targets and associated pharmacological inhibitors. Although these screens affect thousands of gene products, the typical readout is based on low-complexity rather than genome-wide assays. To address this limitation, we introduce Pooled Library Amplification for Transcriptome Expression (PLATE-Seq), a low-cost, genome-wide mRNA profiling methodology specifically designed to complement high-throughput screening (HTS) assays. Introduction of sample-specific barcodes during reverse transcription supports pooled library construction and low-depth sequencing that is 10 to 20-fold less expensive than conventional RNA-Seq. The use of network-based algorithms to infer protein activity from PLATE-Seq data results in comparable reproducibility to 30M read sequencing. Indeed, PLATE-Seq reproducibility compares favorably to other large-scale perturbational profiling studies such as the Connectivity Map (CMap) and Library of Integrated Network-based Cellular Signatures (LINCS).","5":"We use automated liquid-handling to introduce lysis buffer, capture polyadenylated mRNA with an oligo(dT)-grafted plate, and deliver well-specific, barcoded oligo(dT) primers to every sample in a multi-well plate (Figure 1A). After reverse transcription, the cDNA in each well contains a specific barcode sequence on its 5<U+2019>-end and a common adapter, such that all samples can be combined into a single pool for purification and concentration. We then use Klenow Large Fragment for pooled second-strand synthesis from adapter-linked random primers. Because this polymerase lacks strand-displacement and 5<U+2019>-to-3<U+2019> exonuclease activities, each cDNA molecule produces at most, one second-strand synthesis product containing the sample barcode (Figure 1B). Finally, the pooled library is enriched in a single PCR prior to sequencing. The resulting libraries represent the 3<U+2019>-ends of mRNAs and are sequenced to a depth of 0.5-2 million raw reads per sample.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21645322","17":"PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens","18":"[PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens (PMID:28740083)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28740083)","19":"[GEO:GSE97460](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97460), [SRA:SRP103204](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP103204)","_rn_":"141"},{"1":"syn21800136","2":"HI-C 2.0: AN OPTIMIZED HI-C PROCEDURE FOR HIGH-RESOLUTION GENOME-WIDE MAPPING OF CHROMOSOME CONFORMATION","3":"PRJNA384173","4":"Chromosome conformation capture-based methods such as Hi-C have become mainstream techniques for the study of the 3D organization of genomes. These methods convert chromatin interactions reflecting topological chromatin structures into digital information (counts of pair-wise interactions). Here, we describe an updated protocol for Hi-C (Hi-C 2.0) that integrates recent improvements into a single protocol for efficient and high-resolution capture of chromatin interactions. This protocol combines chromatin digestion and frequently cutting enzymes to obtain kilobase (Kb) resolution. It also includes steps to reduce random ligation and the generation of uninformative molecules, such as unligated ends, to improve the amount of valid intra-chromosomal read pairs. This protocol allows for obtaining information on conformational structures such as compartment and topologically associating domains, as well as high-resolution conformational features such as DNA loops.","5":"HI-C 2.0","6":"[\"Hi-C\"]","7":"[\"Human\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21645422","17":"Hi-C 2.0: An optimized Hi-C procedure for high-resolution genome-wide mapping of chromosome conformation","18":"[Hi-C 2.0: An optimized Hi-C procedure for high-resolution genome-wide mapping of chromosome conformation (PMID:28435001)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28435001)","19":"[GEO:GSE98161](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98161), [SRA:SRP105181](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP105181)","_rn_":"142"},{"1":"syn21791499","2":"Chromosomal instability promotes metastasis through a cytosolic DNA response","3":"PRJNA384217","4":"Chromosomal instability (CIN) is a hallmark of cancer, and it results from ongoing errors in chromosome segregation during mitosis. While CIN is a major driver of tumor evolution, its role in metastasis has not been established. Here we show that CIN promotes metastasis by sustaining a tumor-cell autonomous inflammatory response to cytosolic DNA. Errors in chromosome segregation create a preponderance of micronuclei whose envelopes frequently rupture exposing their DNA content to the cytosol. This leads to the activation of the cGAS-STING cytosolic DNA-sensing pathway and downstream noncanonical NF-kB signaling. Genetic suppression of CIN significantly delays metastasis in transplantable tumor models, whereas inducing chromosome segregation errors promotes cellular invasion and metastasis in a STING-dependent manner. In contrast to primary tumors, human and mouse metastases strongly select for CIN, in part, due to its ability to enrich for metastasis-initiating mesenchymal subpopulations, offering an opportunity to target chromosome segregation errors for therapeutic benefit.","5":"To determine whether CIN is causally involved in metastasis, we devised a genetic approach to alter the rate of chromosome missegregation in transplantable tumor models of human TNBC (MDA-MB-231);cont: Control sample. Part of the CIN-medium group.Ka; Overexpression of Kif2a, which does not affect the number of chromosome segregation errors during anaphase and serves as an additional control. Part of the CIN-medium group.Kb; Overexpression of Kif2b, which leads to suppressed chromosome segregation errors during anaphase. Part of the CIN-low group.MK; Overexpression of MCAK which leads to suppressed chromosome segregation errors during anaphase. Part of the CIN-low group.MKH; Overexpression of dominant-negative form of MCAK, leading to increased number of chromosome segregation errors during anaphase. Part of the CIN-high group.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630080, syn21630078, syn21630079","10":"[\"Metabolism\", \"Microenvironment\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349770","14":"[\"CA210184\"]","15":"Center on the Physics of Cancer Metabolism","16":"syn21645269","17":"Chromosomal instability drives metastasis through a cytosolic DNA response","18":"[Chromosomal instability drives metastasis through a cytosolic DNA response (PMID:29342134)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29342134)","19":"[GEO:GSE98183](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98183), [SRA:SRP105199](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP105199)","_rn_":"143"},{"1":"syn12976723","2":"Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization","3":"PRJNA385852","4":"The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understood. The transcription factor CTCF is a candidate regulator of chromosomal structure. Using the auxin-inducible degron system in mouse embryonic stem cells, we show that CTCF is absolutely and dose-dependently required for looping between CTCF target sites and insulation of topologically associating domains (TADs). Restoring CTCF reinstates proper architecture on altered chromosomes, indicating a powerful instructive function for CTCF in chromatin folding. CTCF remains essential for TAD organization in non-dividing cells. Surprisingly, active and inactive genome compartments remain properly segregated upon CTCF depletion, revealing that compartmentalization of mammalian chromosomes emerges independently of proper insulation of TADs. Further, our data support that CTCF mediates transcriptional insulator function through enhancer-blocking but not direct facultative heterochromatin barrier activity. Beyond defining the functions of CTCF in chromosome folding these results provide new fundamental insights into the rules governing mammalian genome organization.","5":"mouse ES cells were engineered to harbor an auxin-inducible degron (AID) tag at both endogenous alleles of CTCF. A transgene encoding the auxin-binding F-box protein Tir1 was subsequently introduce, so that adding auxin to the culture media leads to rapid (hours) and reversible degradation of CTCF. Consequences of acute loss of CTCF and its restoration were investigated using ChIP-seq, RNA-seq and high-throughput Chromosome Conformation Capture (5C and Hi-C).","6":"[\"ChIP-Seq\", \"Hi-C\", \"Whole Transcriptome Sequencing\", \"5C\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21649210","17":"Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization","18":"[Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization (PMID:28525758)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28525758)","19":"[GEO:GSE98671](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98671), [SRA:SRP106652](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP106652)","_rn_":"144"},{"1":"syn21796559","2":"Expression profile of Gastro-Entero-Pancreatic Neuroendocrine Tumors (GEP-NET)","3":"PRJNA386518","4":"Expression profile of human GEP-NET tumors, including 113 fresh frozen biopsies of primary and metastatic tumours originating from pancreas (P-NET, 83 primary and 30 metastasis), 81 from small intestine (SI-NET, 44 primary and 37 metastasis), and 18 from rectum (RE-NET, 3 primary and 15 metastasis).","5":"212 GEP-NET samples with cellularity >70% were analyzed. Total RNA was isolated and RNA integrity assayed by a 2100 Bioanalyzer (Agilent Technologies). High-quality total RNA samples, with RIN (RNA integrity number) above 7, were processed by TruSeq library preparation for RNA-Seq profiling (Illumina). For each sample, a minimum of 30 million 100bp single-end reads or 90 million 100bp paired-end reads were sequenced on the Illumina HiSeq2500 platform. RNA-Seq reads were mapped to the Homo sapiens assembly 19 reference genome, using Bowtie. Reads mapping to known genes, based on Entrez Gene identifiers, were then counted using the GenomicFeatures R-system package (Bioconductor).","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Neuroendocrine Neoplasm\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21681392","17":"A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors","18":"[A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors (PMID:29915428)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29915428)","19":"[GEO:GSE98894](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98894), [SRA:SRP107025](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP107025)","_rn_":"145"},{"1":"syn13858908","2":"Epigenetic restriction of embryonic and extraembryonic lineages mirrors the somatic transition to cancer (Perturbation-RRBS)","3":"PRJNA386936","4":"Concerted efforts over past decades have established a thorough understanding of the canonical somatic DNA methylation landscape as well as its systematic misregulation across most human cancers. However, the underlying mechanism that directs this genome-scale transformation remains elusive, with no clear model for its acquisition or understanding of its potential developmental utility. Here we present base pair resolution analysis of global remethylation from the hypomethylated state of the preimplantation embryo into the early epiblast and extraembryonic ectoderm. We show that these two states acquire highly divergent genomic distributions: while the proximal epiblast establishes a canonical CpG-density dependent pattern found in somatic cells, the extraembryonic epigenome becomes substantially more mosaic. Moreover, this alternate pattern includes specific de novo methylation of hundreds of CpG island promoter containing genes that function in early embryonic development and are orthologously methylated across an extensive cohort of human cancers. From these data, we propose a model where the evolutionary innovation of extraembryonic tissues in eutherian mammals required cooption of DNA methylation-based suppression as an alternate pathway to the embryonically utilized Polycomb group proteins, which otherwise coordinate germ layer formation in response to extraembryonic cues at the onset of gastrulation. Moreover, we establish that this decision is made deterministically downstream of the promiscuously utilized, and frequently oncogenic, FGF signaling pathway and utilizes a novel combination of epigenetic cofactors. Recruitment of this silencing mechanism to developmental genes during cancer therefore reflects the misappropriation of an innate regulatory pathway that may be spontaneously sampled as an alternate epigenetic landscape within somatic cells.","5":"Comparison of DNA methylation patterns in Extraembryonic Ectoderm and cancer","6":"[\"Bisulfite Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21645383","17":"Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer","18":"[Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer (PMID:28959968)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28959968)","19":"[GEO:GSE98963](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98963), [SRA:SRP107210](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP107210)","_rn_":"146"},{"1":"syn21791720","2":"A comparison between single cell RNA sequencing and single molecule RNA FISH for rare cell analysis","3":"PRJNA388108","4":"We use single molecule RNA FISH measurements of 26 genes in thousands of melanoma cells to provide an independent reference dataset to assess the performance of the DropSeq and Fluidigm single cell RNA sequencing platforms. We quantified the Gini coefficient, a measure of rare-cell expression variability, and find that the correspondence between RNA FISH and single cell RNA sequencing for Gini, unlike for mean, increases markedly with per-cell library complexity up to a threshold of ~2000 genes detected. A similar complexity threshold also allows for robust assignment of multi-genic cell states such as cell cycle phase.","5":"Comparison of gene expression estimates obtained through 3 different platforms (RNA FISH, DropSeq, and Fluidigm's C1 HT IFC) using the same cell line.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Melanoma\"]","9":"syn21630078, syn21630081, syn21630079","10":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349747","14":"[\"CA193417\"]","15":"Physical Science Oncology Center at Penn","16":"syn21648897","17":"Rare Cell Detection by Single-Cell RNA Sequencing as Guided by Single-Molecule RNA FISH","18":"[Rare Cell Detection by Single-Cell RNA Sequencing as Guided by Single-Molecule RNA FISH (PMID:29454938)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29454938)","19":"[GEO:GSE99330](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99330), [SRA:SRP108076](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP108076)","_rn_":"147"},{"1":"syn21796402","2":"Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13","3":"PRJNA388315","4":"The constitutively active androgen receptor (AR) splice variant 7 (AR-V7) plays an important role in the progression of castration-resistant prostate cancer (CRPC). Although biomarker studies established the role of AR-V7 in resistance to AR-targeting therapies, how AR-V7 mediates genomic functions in CRPC remains largely unknown. Using a ChIP-exo approach, we show AR-V7 binds to distinct genomic regions and recognizes a full-length androgen-responsive element in CRPC cells and patient tissues. Remarkably, we find dramatic differences in AR-V7 cistromes across diverse CRPC cells and patient tissues, regulating different target gene sets involved in CRPC progression. Surprisingly, we discover that HoxB13 is universally required for and colocalizes with AR-V7 binding to open chromatin across CRPC genomes. HoxB13 pioneers AR-V7 binding through direct physical interaction, and collaborates with AR-V7 to up-regulate target oncogenes. Transcriptional coregulation by HoxB13 and AR-V7 was further supported by their coexpression in tumors and circulating tumor cells from CRPC patients. Importantly, HoxB13 silencing significantly decreases CRPC growth through inhibition of AR-V7 oncogenic function. These results identify HoxB13 as a pivotal upstream regulator of AR-V7-driven transcriptomes that are often cell context-dependent in CRPC, suggesting that HoxB13 may serve as a therapeutic target for AR-V7-driven prostate tumors.","5":"To identify AR-V7 and HoxB13 binding sites in CRPC, ChIP-exo and ATAC-seq were performed in CRPC cells and tissues. RNA-seq was performed to examine AR-V7 and HoxB13 regulated profiles. Each experiment includes two biological replicates.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21649073","17":"Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13","18":"[Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13 (PMID:29844167)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29844167)","19":"[GEO:GSE99378](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99378), [SRA:SRP108215](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP108215)","_rn_":"148"},{"1":"syn21791182","2":"Persistence of stem cell metabolism in cancers as a failure of differentiation","3":"PRJNA389596","4":"Tumor glucose uptake was measured by FDG-PET in 859 patients with histologically diverse cancers. We used normal mixture modeling to explore FDG-PET standardized uptake values (SUV) distributions and tested for association between glucose uptake and histological differentiation, risk of lymph node metastasis, and survival. Using RNA-seq data, we performed pathway and transcription factor analyses to compare tumors with high and low levels of glucose uptake. We found that well-differentiated tumors had low FDG uptake, while moderately and poorly differentiated tumors had higher uptake. The distribution of SUV for each histology was bimodal with a low peak at SUV 2-4 and a high peak at SUV 8-11. The cancers in the two modes were clinically distinct in terms of the risk of nodal metastases and of death. Carbohydrate metabolism and the pentose related pathway were elevated in the poorly differentiated/high SUV clusters. Embryonic stem cell-related signatures were activated in poorly differentiated/ high SUV clusters.","5":"Comparison of gene expression pattern in cancer with high and low SUV.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Lung Adenocarcinoma\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681326","17":"The Warburg effect: persistence of stem-cell metabolism in cancers as a failure of differentiation","18":"[The Warburg effect: persistence of stem-cell metabolism in cancers as a failure of differentiation (PMID:29045536)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29045536)","19":"[GEO:GSE99790](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99790), [SRA:SRP108785](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP108785)","_rn_":"149"},{"1":"syn21791317","2":"Single-cell RNA-seq reveals a subpopulation of prostate cancer cells with enhanced cell cycle-related transcription and attenuated androgen response","3":"PRJNA389624","4":"Increasing evidence indicates that minor subpopulations intrinsic to androgen-independence are present in prostate cancer cells, poised to become clonal dominance under prolonged androgen-deprivation selection. To stratify different subpopulations, we conduct transcriptome profiling of 144 single LNCaP prostate cancer cells treated and untreated with androgen after cell cycle synchronization. At least eight subpopulations of LNCaP cells are identified, revealing a previously unappreciable level of cellular heterogeneity to androgen stimulation. One subpopulation displays stem-like features, the advanced growth of which depends more on enhanced expression of 10 cell cycle-related genes and less on androgen-dependent signaling. Concordant upregulation of these genes appears to be linked to recurrent prostate cancers and can be used for early detection of tumors that subsequently develop androgen independence. Moreover, this single-cell approach provides a better understanding of how cancer cells respond heterogeneously to androgen-deprivation therapies and to reveal which subpopulations are resistant to this treatment.","5":"For each of 3 treatment groups, forty eight LNCaP single cells and 1 representative bulk cell RNA sample (1ng) were collected for SMART-seq2 amplification and later single-cell RNA-seq (total 144 single cells and 3 bulk cell samples). All of the treatment groups were harvested from after synchronizing the cells at the G1/S phase with a double thymidine block and androgen depriving the cells for ~24 hours. Treatment groups 2 and 3 were cultured in the absence and presence of androgen (1 nM R1881) for 12 hours, respectively. Treatment group 1 was a baseline comparison treatment group and was collected right after cell synchronization and androgen deprivation (considered 0 hour).","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21645255","17":"Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response","18":"[Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response (PMID:29233929)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29233929)","19":"[GEO:GSE99795](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99795), [SRA:SRP108807](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP108807)","_rn_":"150"},{"1":"syn21796552","2":"Chemically Induced Paneth Cells Provide Superior In Vivo Mimic to Organoid-derived Analog","3":"PRJNA391194","4":"Paneth cells (PCs) are post-mitotic secretory cells of the small intestine that produce antimicrobials, growth factors, and cytokines. Multiple diseases have been linked to alterations in PC function. Past studies of PCs have relied on in vivo models, and limited in vitro models, including organoids. While useful, whether the in vitro models recapitulate in vivo biology is an important, yet unanswered question. Here, we present a bona fide in vitro PC-enriched population derived via chemically-induced (CI) differentiation of primary murine adult stem cells. We define the identity of PCs in our system and compare to PCs of established organoid systems and those found in vivo. Importantly, we demonstrate stimulant-induced and microbe-responsive antimicrobial function of our CI-PCs <U+2013> hallmark functions of PCs in vivo. Thus, we define and produce the most physiologically-relevant in vitro PC population to date, providing a superior tool to study cellular development, host-microbe interactions, and inflammatory disease.","5":"Single-cell RNA sequencing experiments on Seq-Well platform of ENR (Control), ENR+CD (Paneth enriched), and ENR+CV (ISC-enriched) organoids.\\nOrg_All_merged.txt: merged UMI file","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773338","14":"[\"CA217377\"]","15":"Quantitative and Functional Characterization of Therapeutic Resistance in Cancer","16":"syn21648934","17":"Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types","18":"[Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types (PMID:29871632)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29871632)","19":"[GEO:GSE100274](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE100274), [SRA:SRP109858](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP109858)","_rn_":"151"},{"1":"syn21792707","2":"Gene expression changes associated with high density collagen microenviroment in cancer cells","3":"PRJNA393881","4":"We report RNA sequencing data from 2 cancer cell line (fibrosarcoma, HT1080 and Breast cancer, MDA-MB-231) and one non-canceours cell line (human foreskin fibroblast HFF) embbeded in two different 3D collagen matrix environements. The topographical organization of collagen within the tumor ECM has been implicated in guiding cancer cell migration and independently predicts progression to metastasis. Here, we show that collagen matrices with small pores and short fibers, but not Matrigel, trigger a conserved transcriptional response and subsequent motility switch in cancer cells that results in formation of multicellular network structures. The response is not mediated by hypoxia, matrix stiffness, or bulk matrix density, but by matrix architecture and beta1 integrin upregulation. The transcriptional module associated with network formation is enriched for migration and vasculogenesis-associated genes that predicted survival in patient data across nine distinct tumor types. Evidence at the protein level of this gene module is found in patient tumors displaying a vasculogenic mimicry (VM) phenotype. Our findings link a collagen matrix-induced migration program to VM, and suggest that this process may be broadly relevant to metastatic progression in solid human cancers.","5":"Total RNA extraction and mRNA sequencing of 3 diiferent cell lines cultured in 2 different collagen matrix conditions.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630075, syn21630081, syn21630076","10":"[\"Heterogeneity\", \"Evolution\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn10140998","14":"[\"CA209891\"]","15":"The Cancer Cell Map Initiative","16":"syn21648894","17":"A global transcriptional network connecting noncoding mutations to changes in tumor gene expression","18":"[A global transcriptional network connecting noncoding mutations to changes in tumor gene expression (PMID:29610481)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29610481)","19":"[GEO:GSE101209](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE101209), [SRA:SRP111555](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP111555)","_rn_":"152"},{"1":"syn21796537","2":"Acid suspends the circadian clock in hypoxia through inhibition of mTOR","3":"PRJNA396153","4":"Recent reports indicate hypoxia influences the clock through the transcriptional activities of hypoxia inducible factors (HIFs) at clock genes. Unexpectedly, we uncover a profound disruption of the circadian clock and diurnal transcriptome when hypoxic cells are permitted to acidify, recapitulating the tumor microenvironment. Buffering against acidification or inhibiting lactic acid production fully rescues circadian oscillation. Acidification of several human and murine cell lines, as well as primary murine T cells, suppresses mechanistic target of rapamycin complex 1 (mTORc1) signaling, a key regulator of translation in response to metabolic status. We find acid drives peripheral redistribution of normally perinuclear lysosomes, inhibiting lysosome-bound mTOR. Restoring mTORc1 signaling and the translation it governs rescues clock oscillation, revealing a model in which lactic acid produced during the cellular metabolic response to hypoxia suppresses the circadian clock through diminished translation of clock constituents.","5":"RNA-sequencing was performed over a 52-hour timecourse using total RNA collected every 4 hours from U2OS human osteosarcoma cells in media of pH 7.4 or pH 6.3","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Osteosarcoma\"]","9":"syn21630081, syn21630076, syn21630078, syn21630077","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Tumor-Immune\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349753","14":"[\"CA193489\"]","15":"H Lee Moffitt Cancer Center and Research Institute","16":"syn21681382","17":"Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR","18":"[Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR (PMID:29861175)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29861175)","19":"[GEO:GSE101988](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE101988), [SRA:SRP113754](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP113754)","_rn_":"153"},{"1":"syn13857535","2":"Mitotic chromosomes fold by condensin-dependent helical winding of chromatin loop arrays","3":"PRJNA398543","4":"Mitotic chromosome morphogenesis occurs through condensin-mediated disassembly of the interphase conformation and formation of extended prophase loop arrays that then shorten by condensin-dependent helical winding","5":"Chromosome organization investigation through Hi-C","6":"[\"Hi-C\"]","7":"[\"Human\", \"Chicken\"]","8":"[\"Malignant Peripheral Nerve Sheath Tumors\"]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21649214","17":"A pathway for mitotic chromosome formation","18":"[A pathway for mitotic chromosome formation (PMID:29348367)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29348367)","19":"[GEO:GSE102740](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE102740), [SRA:SRP115572](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP115572)","_rn_":"154"},{"1":"syn21809588","2":"Endometrial epithelial cell transcriptome response to co-culture with adipose stromal cells","3":"PRJNA400484","4":"The role of obesity in endometrial cancer development is tested by co-culturing adipose stromal cells (ASCs) with endometrial epithelial cells and endometrial cancer cell Ishikawa for 21 days. Control cells (not exposed to ASCs) were incubated for the same duration. RNA-seq identified differential expression due to ASC exposure","5":"Transcriptoms effects in enomdetrial epithelial cells is exmined by RNA-seq after adipose stromal cell co-culture","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681447","17":"Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer","18":"[Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer (PMID:30389702)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30389702)","19":"[GEO:GSE103203](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103203), [SRA:SRP116341](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP116341)","_rn_":"155"},{"1":"syn11342978","2":"Single-Cell Transcriptome Analysis of Lineage Diversity and Microenvironment in High-Grade Glioma","3":"PRJNA400576","4":"Despite extensive molecular characterization, we lack a comprehensive picture of lineage identity, differentiation, and microenvironmental composition in high-grade gliomas (HGGs). We sampled the cellular milieu of HGGs with massively-parallel single-cell RNA-Seq. While HGG cells can resemble glia or even immature neurons and form branched lineage structures, mesenchymal transformation results in unstructured populations. Glioma cells in a subset of mesenchymal tumors lose their neural lineage identity, express inflammatory genes, and co-exist with marked myeloid infiltration, implying a molecular interaction between glioma and immune cells. Finally, we found that myeloid cells can resemble microglia, macrophages, or a hybrid state, and enrichment of these cells is predictive of poor survival.","5":"Performed single cell RNA-seq on tens of thousands of dissociated high-grade glioma tissue cells from 8 human patients.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Glioma\"]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21648977","17":"Single-cell transcriptome analysis of lineage diversity in high-grade glioma","18":"[Single-cell transcriptome analysis of lineage diversity in high-grade glioma (PMID:30041684)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30041684)","19":"[GEO:GSE103224](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103224), [SRA:SRP116382](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP116382)","_rn_":"156"},{"1":"syn21792744","2":"Tumor evolution and drug response in patient-derived organoid models of bladder cancer","3":"PRJNA407895","4":"Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied and relatively lacking in suitable models. Here we describe a biobank of patient-derived organoid lines that recapitulates the spectrum of human bladder cancer at the histopathological and molecular levels. Organoid lines can be established efficiently from patient biopsies, including from patients before and after disease recurrence, and are interconvertible with orthotopic xenografts. Notably, these organoid lines often retain tumor heterogeneity and exhibit changes in their mutational profiles that are consistent with tumor evolution in culture. Analyses of drug response using bladder tumor organoids show partial correlations with mutational profiles as well as changes associated with treatment resistance, and specific responses can be validated using xenografts in vivo. Overall, our studies indicate that patient-derived bladder tumor organoids represent a model system for studying tumor evolution and treatment response in the context of precision cancer medicine.","5":"We generated organoids from bladder tumor tissue. The organoids were trypsinized, plated in matrigel and overlaid with medium. The medium was changed every 3 days. After 14 days of plating, Organoids were harvested and processed for RNA isolation and transcriptome analysis using Ambion MagMAX RNA isolation kit.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Bladder\"]","9":"syn21630075, syn21630081, syn21630079","10":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349759","14":"[\"CA193313\"]","15":"Columbia University Center for Topology of Cancer Evolution and Heterogeneity","16":"syn21648885","17":"Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer","18":"[Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer (PMID:29625057)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29625057)","19":"[GEO:GSE103990](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103990), [SRA:SRP118077](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP118077)","_rn_":"157"},{"1":"syn21791465","2":"Expression data from human endothelial cells co-cultured with cancer associated fibroblasts","3":"PRJNA417079","4":"Cancer associated fibroblasts (CAFs) have been shown to plays crucial roles in cancer progression. Although increasing evidence demonstrates that CAFs have important roles in modulating the aggressive phenotypes of cancer cells, their effects on the tumor vasculature remain underexplored. We co-cultured TIME human microvascular endothelial cells (MECs) with either primary human ovarian CAFs or normal ovarian fibroblasts (NFs) to evaluate the effects of CAFs on phenotypes of endothelial cells.","5":"RNA samples isolated from TIME cells that had been co-cultured with CAFs or NFs was analyzed using Affymetrix Clariom D human gene expression assays.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"Malignant Neoplasm of Ovary\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775595","14":"[\"CA188388\"]","15":"Modeling and targeting stroma-tumor crosstalk in non small cell lung cancer","16":"syn21648893","17":"Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance","18":"[Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance (PMID:29251630)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29251630)","19":"[GEO:GSE106519](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE106519)","_rn_":"158"},{"1":"syn21791468","2":"Fenofibrate Prevents Skeletal Muscle Loss in Mice with Lung Cancer","3":"PRJNA420195","4":"The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly prevalent in non-small cell lung cancer (NSCLC). Loss of skeletal muscle results in functional impairments and increased mortality. The aim of the current study was to characterize the changes in systemic metabolism in a genetically engineered mouse model of NSCLC. We show that a portion of these animals develop loss of skeletal muscle, loss of adipose tissue, and increased inflammatory markers mirroring the human cachexia syndrome. Using non-cachexic and fasted animals as controls, we report a unique cachexia metabolite phenotype that includes the dependent ketone production by the liver. In this setting, glucocorticoid levels rise and correlate with skeletal muscle degradation and hepatic markers of gluconeogenesis. Restoring prevents the loss of skeletal muscle mass and body weight. These results demonstrate how targeting hepatic metabolism can prevent muscle wasting in lung cancer, and provide evidence for a novel therapeutic strategy.","5":"Using an inducible lung cancer model, we characterize the changes in intermediary metabolism that occur during cancer anorexia cachexia syndrome (CACS) in mice. We performed RNA-seq on the livers and gastrocnemius muscle of on non-CACS, CACS, and fasted mice.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Lung Non-Small Cell Carcinoma\"]","9":"syn21630080, syn21630078, syn21630079","10":"[\"Metabolism\", \"Microenvironment\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349770","14":"[\"CA210184\"]","15":"Center on the Physics of Cancer Metabolism","16":"syn21648884","17":"Fenofibrate prevents skeletal muscle loss in mice with lung cancer","18":"[Fenofibrate prevents skeletal muscle loss in mice with lung cancer (PMID:29311302)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29311302)","19":"[GEO:GSE107470](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE107470), [SRA:SRP125804](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP125804)","_rn_":"159"},{"1":"syn21792798","2":"A CLK3-HMGA2 alternative splicing axis impacts human hematopoietic stem cell molecular identity throughout development [HSC and PROG RNA-seq]","3":"PRJNA429647","4":"While gene expression dynamics have been extensively catalogued during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and post-transcriptional changes in HSCs during development, we leveraged high-throughput genomic approaches to profile miRNAs, lincRNAs, and mRNAs. Our findings indicate that HSCs manifest distinct alternative splicing patterns in key hematopoietic regulators. Detailed analysis of the splicing dynamics and function of one such regulator, HMGA2, identified an alternative isoform that escapes miRNA-mediated targeting. We further identified the splicing kinase CLK3 that, by regulating HMGA2 splicing, preserves HMGA2 function in the setting of an increase in let-7 miRNA levels, delineating how CLK3 and HMGA2 form a functional axis that influences HSC properties during development. Collectively, our study highlights molecular mechanisms by which alternative splicing and miRNA-mediated post-transcriptional regulation impact the molecular identity and stage-specific developmental features of human HSCs.","5":"RNA-seq of hematopoietic stem cells (HSC) and progenitor cells (PROG) from fetal liver (FL), cord blood (CB) and bone marrow (BM) and control HPC cells differentiated from IPSC cells.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21648960","17":"A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development","18":"[A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development](https://www.ncbi.nlm.nih.gov/pubmed/?term=29625070)","19":"[GEO:GSE109089](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109089)","_rn_":"160"},{"1":"syn21792787","2":"A CLK3-HMGA2 alternative splicing axis impacts human hematopoietic stem cell molecular identity throughout development [HSC and PROG miRNA profiling]","3":"PRJNA429648","4":"While gene expression dynamics have been extensively catalogued during hematopoietic differentiation in the adult, less is known about transcriptome diversity of human hematopoietic stem cells (HSCs) during development. To characterize transcriptional and post-transcriptional changes in HSCs during development, we leveraged high-throughput genomic approaches to profile miRNAs, lincRNAs, and mRNAs. Our findings indicate that HSCs manifest distinct alternative splicing patterns in key hematopoietic regulators. Detailed analysis of the splicing dynamics and function of one such regulator, HMGA2, identified an alternative isoform that escapes miRNA-mediated targeting. We further identified the splicing kinase CLK3 that, by regulating HMGA2 splicing, preserves HMGA2 function in the setting of an increase in let-7 miRNA levels, delineating how CLK3 and HMGA2 form a functional axis that influences HSC properties during development. Collectively, our study highlights molecular mechanisms by which alternative splicing and miRNA-mediated post-transcriptional regulation impact the molecular identity and stage-specific developmental features of human HSCs.","5":"miRNA profiling of hematopoietic stem cells (HSC) and progenitor cells (PROG) from fetal liver (FL), cord blood (CB) and bone marrow (BM) and control HPC cells differentiated from IPSC cells.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21648960","17":"A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development","18":"[A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development](https://www.ncbi.nlm.nih.gov/pubmed/?term=29625070)","19":"[GEO:GSE109092](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109092)","_rn_":"161"},{"1":"syn21797924","2":"Preclinical model of obesity and ER-positive breast cancer","3":"PRJNA434156","4":"Here, we developed a mouse model of diet induced obesity that is graft competent. In this model, we grew an ER-positive breast cancer patient derived tumor. Following ovariectomy and estrogen deprivation therapy, tumors continued to grow in obese but not lean mice. RNAsequencing analysis was performed on tumors from estrogen-supplemented lean mice, and from lean and obese mice after estrogen deprivation. This analysis identified fibroblast growth factor receptor signaling as a potential driver of tumor progression in the context of obesity.","5":"LFLS E2 N=4; LFLS EWD N=4; HFHS EWD N=4, HFHS E2 N=3","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630080, syn21630078, syn21630079","10":"[\"Metabolism\", \"Microenvironment\", \"Metastasis\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349770","14":"[\"CA210184\"]","15":"Center on the Physics of Cancer Metabolism","16":"syn21681403","17":"FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation","18":"[FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation (PMID:30046001)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30046001)","19":"[GEO:GSE110644](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110644), [SRA:SRP132902](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP132902)","_rn_":"162"},{"1":"syn21797856","2":"A consensus hypoxia signature in breast cancer","3":"PRJNA437670","4":"We exposed a panel of 32 breast cancer cell lines or normal human mammary epithelial cells to 20% or 1% O2 concentration for 24h. Total RNA was extracted from cells using TRIzol (Invitrogen) and treated with DNase I (Ambion). All samples had a RIN value of >9.0 when measured on an Agilent Bioanalyzer. Libraries for RNA-Seq were prepared with KAPA Stranded RNA-Seq Kit. The workflow consisted of mRNA enrichment, cDNA generation, end repair to generate blunt ends, A-tailing, adaptor ligation and 12 cycles of PCR amplification. Unique adaptors were used for each sample in order to multiplex samples into several lanes. Sequencing was performed on Illumina Hiseq 3000/4000 with a 150bp pair-end run. A data quality check was done on Illumina SAV. Demultiplexing was performed with Illumina Bcl2fastq2 v 2.17 program.","5":"32 breast cancer cell lines exposedto standard tissue culture conditions normoxic (20% O2) or hypoxic (1% O2) conditions.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630078, syn21630079, syn21630080","10":"[\"Microenvironment\", \"Metastasis\", \"Metabolism\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349766","14":"[\"CA210173\"]","15":"Johns Hopkins Physical Sciences Oncology Center (PS-OC)","16":"syn21681401","17":"Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes","18":"[Molecular Portrait of Hypoxia in Breast Cancer: A Prognostic Signature and Novel HIF-Regulated Genes (PMID:30037853)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30037853)","19":"[GEO:GSE111653](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE111653), [SRA:SRP134389](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP134389)","_rn_":"163"},{"1":"syn21812746","2":"Stromal Fibroblasts Drive Single Cell Heterogeneity in Pancreatic Cancer","3":"PRJNA464359","4":"To understand the interplay between cancer and stroma, we performed single cell RNA-sequencing of PDAC cells admixed with stromal fibroblasts and defined different single cell populations with varying levels of proliferative and metastatic transcriptional states. PDAC cell behavior in vitro and in vivo on these phenotypic axes could be tuned with the proportion of stromal fibroblasts. These cell types were identified in human pancreatic tumors, and specific subpopulations were associated with worsened outcomes.","5":"92 single PDAC cells and 92 single CAF cells were micromanipulated and prepared for sequencing (23 of each cell type from four culture ratios). The 24th sample from each cell type-culture condition combination is a population control obtained by micromanipulating 100 cells of the given type from the given culture condition and preparing it as if it were a single cell, giving a total of 96 PDAC samples and 96 CAF samples. During the course of library construction, 3 samples were lost, all PDAC cells from the 30:70 condition (two single cells and the population control), leaving 93 total PDAC samples and 96 total CAF samples.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\"]","8":"[\"Malignant Neoplasm of Pancreas\"]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084053","14":"[\"CA215798\"]","15":"Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy","16":"syn21681772","17":"Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer","18":"[Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer (PMID:31155233)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31155233)","19":"[GEO:GSE113616](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113616), [SRA:SRP144750](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP144750)","_rn_":"164"},{"1":"syn21809444","2":"Decidualization of human endometrial stromal fibroblasts is a multi-phasic process involving distinct transcriptional programs","3":"PRJNA470821","4":"We sequenced mRNA from endometrial stromal fibroblasts and decidual stromal cells after 3 day and 8 days decidualization treatment","5":"We sequenced mRNA from endometrial stromal fibroblasts (n=3), and after 3days (n=3) or 8 days (n=2) in vitro decidulization with cAMP and progesterone (MPA)","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315810","14":"[\"CA209992\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion","16":"syn21681436","17":"Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs","18":"[Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs (PMID:30309298)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30309298)","19":"[GEO:GSE114296](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114296), [SRA:SRP145267](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP145267)","_rn_":"165"},{"1":"syn21797729","2":"Systematic immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival.","3":"PRJNA470891","4":"Success of immune checkpoint inhibitors in advanced non-small cell lung cancer (NSCLC) has invigorated their use in neo-adjuvant setting for early-stage disease. However, the cellular and molecular mechanisms of the early immune responses to therapy remain poorly understood. Through an integrated analysis of early-stage NSCLC patients and a Kras-mutant mouse model, we show a prevalent programmed cell death 1/ programmed cell death 1 ligand 1 (PD-1/PD-L1) axis exemplified by increased intratumoral PD-1+ T cells and PD-L1 expression. Notably, tumor progression was associated with spatiotemporal modulation of the immune microenvironment. Importantly, PD-1 inhibition controlled tumor growth, improved overall survival, and reprogrammed tumor-associated lymphoid and myeloid cells. Depletion of T lymphocyte subsets demonstrated synergistic effects of those populations on PD-1 inhibition of tumor growth. Transcriptome analyses revealed T cell subset-specific alterations corresponding to degree of response to the treatment. These results provide insights into temporal evolution of the phenotypic effects of PD-1/PD-L1 activation and inhibition, and motivate targeting this axis early in lung cancer progression.","5":"CD4 and CD8 lung tumor infiltrating lymphocytes were sorted into RLT lysis buffer from IgG antibody or anti-PD1 antibody treated C57Bl/6 mice at day 14, 17 or 24 for mRNA-Sequencing.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Lung Non-Small Cell Carcinoma\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775595","14":"[\"CA188388\"]","15":"Modeling and targeting stroma-tumor crosstalk in non small cell lung cancer","16":"syn21649081","17":"Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival","18":"[Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival (PMID:29997286)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29997286)","19":"[GEO:GSE114300](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114300), [SRA:SRP145321](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP145321)","_rn_":"166"},{"1":"syn21797667","2":"Single cell RNA-seq and ATAC-seq of EMT induced by TGFbeta stimulation and Zeb1 overexpression","3":"PRJNA471293","4":"We report the application of single cell RNA-sequencing using indrop on an HMLE breast cancer cell line that we induced to undergo EMT. We measured 7523 single cells after 8 and 10 days of stimulation with TGFbeta. In addition, we measured 3496 single cells in an engineered HMLE cell line with Dox inducible Zeb1, after 2 days of stimulation with Doxycycline. Finally, we performed ATAC-seq on CD44 sorted HMLE cells after 8 days of stimulation with TGFbeta.","5":"Single cell RNA-seq on two different cell lines and ATAC-seq on one cell line","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21681394","17":"Recovering Gene Interactions from Single-Cell Data Using Data Diffusion","18":"[Recovering Gene Interactions from Single-Cell Data Using Data Diffusion (PMID:29961576)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29961576)","19":"[GEO:GSE114397](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114397), [SRA:SRP145597](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP145597)","_rn_":"167"},{"1":"syn21797940","2":"A PDGFR<U+03B1>-driven mouse model of Glioblastoma reveals a Stathmin1-mediated mechanism of sensitivity to Vinblastine","3":"PRJNA471344","4":"Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFR<U+03B1> and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of PDGFR<U+03B1> and the analysis of GBM signaling pathways using proteomics. We discovered the tubulin-binding protein Stathmin1 (STMN1) as a PDGFR<U+03B1> phospho-regulated target and that this mis-regulation conferred selective sensitivity to vinblastine (VB) cytotoxicity. Treatment of PDGFR<U+03B1> GBMs with VB in mice drastically prolonged survival and was dependent on STMN1. Our work provides a rationale for evaluating genotype-specific anti-microtubule drugs as cancer treatment in select GBM patient populations.","5":"Total RNA was isolated from flash frozen tumors freshly excised from mice using Qiagen RNeasy RNA Isolation Kit. Gene expression analysis was conducted using the GeneChip<U+00AE> Mouse 2.0 ST Array (Affymetrix) at the Yale Center for Genome Analysis. Three biological replicates were profiles for each condition","6":"[\"Expression Array\"]","7":"[\"Mouse\"]","8":"[\"Glioblastoma\"]","9":"syn21630081, syn21630076, syn21630078, syn21630075","10":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Heterogeneity\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349757","14":"[\"CA193461\"]","15":"Dana-Farber Cancer Institute Physical Sciences-Oncology Center","16":"syn21681409","17":"A PDGFR<U+03B1>-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine","18":"[A PDGFR<U+03B1>-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine (PMID:30082792)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30082792)","19":"[GEO:GSE114438](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114438)","_rn_":"168"},{"1":"syn21812642","2":"Total RNA profiles in response to four tyrosine kinase inhibitors in human induced pluripotent stem cell-derived cardiomyocytes","3":"PRJNA472575","4":"To define molecular markers of tyrosine kinase inhibitor-induced cardiotoxicity, we measured transcriptome changes in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with one of four tyrosine kinase inhibitors (Erlotinib, Lapatinib, Sorafenib, or Sunitinib) displaying a range of mild to severe cardiotoxicity or a vehicle-only control (DMSO). Gene expression changes were assessed at the cell population level using total RNA-seq, which measured levels of both mRNAs and non-coding RNAs.<U+00A0>hiPSC-CMs used in this study were the Cor.4U cells purchased from Ncardia.","5":"hiPSC-CMs were treated with each TKI (Erlotinib, Lapatinib, Sorafenib or Sunitinib) at three doses (1, 3 and 10 <U+00B5>M) for 24 hours and the intermediate dose (3 <U+00B5>M) for an additional three time points (6h, 72h and 168h). hiPSC-CMs were also treated with the DMSO vehicle-only control at four time points (6h, 24h, 72h and 168h). Each treatment condition had three biological replicates, collected from three independent experiments using three different lots of hiPSC-CMs. Total RNA was collected from all these samples.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681737","17":"Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming","18":"[Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming (PMID:31078528)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31078528)","19":"[GEO:GSE114686](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE114686), [SRA:SRP148659](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP148659)","_rn_":"169"},{"1":"syn21814211","2":"RNA sequencing on circulating tumor cells from prostate cancer patients","3":"PRJNA475218","4":"Circulating tumor cells (CTCs) undergo considerable stress in the bloodstream. To understand the underlying phenomenon, we conducted single-cell genomic or transcriptomic analyses of primary tumor cells shed in urine and CTCs in blood of prostate cancer patients. Of more than four hundred focal genomic alterations analyzed, increased and decreased copy-numbers of 113 recurrent regions were found in CTCs relative to primary tumor cells. Tumor cells with these pre-existing genomic alterations can be adaptively selected, allowing for transcription reprogramming during blood circulation. These regions harbored genes associated with oxidative phosphorylation machineries that are exploited by CTCs for alternative energy metabolism.","5":"Examination of prostate CTCs transcriptomic profile in single cell level","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681993","17":"Spatial EGFR Dynamics and Metastatic Phenotypes Modulated by Upregulated EphB2 and Src Pathways in Advanced Prostate Cancer","18":"[Spatial EGFR Dynamics and Metastatic Phenotypes Modulated by Upregulated EphB2 and Src Pathways in Advanced Prostate Cancer (PMID:31805710)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31805710)","19":"[GEO:GSE115501](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115501), [SRA:SRP150061](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP150061)","_rn_":"170"},{"1":"syn21811363","2":"Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans","3":"PRJNA475273","4":"Purpose: We found that mutations in microtubule regulating factors lead to altered lifespan. In order to understand the mechnaisms, we carried out RNA-seq analyses to identify genes with differential expression in microtubule regulator mutants.","5":"Genetic mutants of efa-6, hdac-6, ptl-1 and ptrn-1 were compared to wildtype control. Synchronized Day 1 young adults were used for RNA extraction.","6":"[]","7":"[\"Worm\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681517","17":"Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans","18":"[Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans (PMID:30638295)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30638295)","19":"[GEO:GSE115531](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115531), [SRA:SRP150084](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP150084)","_rn_":"171"},{"1":"syn21809478","2":"Transcriptome analysis of Group 3 and 4 medulloblastoma orthotopic xenograft mice with digoxin treatment","3":"PRJNA475298","4":"RNA-seq data of Group 3 and 4 medulloblastoma with digoxin treatment.","5":"Investigate the differential expressed genes in Group 3 and 4 Medulloblastoma under digoxin treatment","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Medulloblastoma\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775595","14":"[\"CA188388\"]","15":"Modeling and targeting stroma-tumor crosstalk in non small cell lung cancer","16":"syn21681442","17":"Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma","18":"[Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma (PMID:30355798)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30355798)","19":"[GEO:GSE115542](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115542), [SRA:SRP150101](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP150101)","_rn_":"172"},{"1":"syn21796439","2":"Systematic Identification of Epithelial<U+2013>Stromal Crosstalk Signaling Networks in Ovarian Cancer","3":"PRJNA475593","4":"Ovarian cancer is the most lethal malignancy in the United States. While studies on ovarian cancer pathogenesis were mainly focused on the epithelial component of the tumor, understanding in the role of cancer associated fibroblasts (CAFs) in ovarian cancer progression is limited. In the present study, we describe the use of microdissected transcriptome profiles for the identification of cancer<U+2013>stroma crosstalk networks with prognostic value, which presents a unique opportunity for developing new treatment strategies for ovarian cancer.","5":"Transcriptome profiling analyses were performed on laser microdissected cancer associated stroma samples and epithelial tumor samples from high grade serous ovarian cancer patients using the Affymetrix human genome U133 Plus 2.0 microarray. Based on the transcriptome profiles, computer program cell-cell communication explorer (CCCExplorer) was used to predict signaling crosstalks between cancer associated fibroblasts and ovarian cancer cells.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[\"Malignant Neoplasm of Ovary\"]","9":"syn21630075, syn21630078","10":"[\"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775595","14":"[\"CA188388\"]","15":"Modeling and targeting stroma-tumor crosstalk in non small cell lung cancer","16":"syn21681378","17":"Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer","18":"[Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer (PMID:29860390)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29860390)","19":"[GEO:GSE115635](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115635)","_rn_":"173"},{"1":"syn21797976","2":"Transcriptome of human decidual cells treated by siRNA targeting FOXO1","3":"PRJNA476236","4":"Here we report the gene expression profile of in vitro cultured human endometrial stromal cells treated with siRNA targeting FOXO1 piror to eutherian differentiation media exposure. The eutherian differentiation media contains cyclic AMP (cAMP) analogue 8-Br-cAMP and the progesterone (P4) analogue medroxyprogesterone acetate (MPA).","5":"RNA-seq on decidualizing human endometrial stromal cells treated with siRNA targeting FOXO1.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315810","14":"[\"CA209992\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion","16":"syn21681412","17":"The mammalian decidual cell evolved from a cellular stress response","18":"[The mammalian decidual cell evolved from a cellular stress response (PMID:30142145)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30142145)","19":"[GEO:GSE115832](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115832), [SRA:SRP150586](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP150586)","_rn_":"174"},{"1":"syn21797922","2":"Real-time quantitative PCR analysis of induced pluripotent derived endothelial cells","3":"PRJNA476340","4":"CD31+/VECad+ hiPSC-ECs were purified through magnetic activated cell sorting. Expanded endothelial cells were then subjected to serum starvation conditions for 24 hours by culturing in DMEM. After serum starvation, total RNA was extracted. We used a custom Thermo Fisher Scientific PCR assay panel to quantify gene expression relevant to ciliogenesis, cytoskeletal integrity, Wnt signaling, pluripotency and endothelial phenotype.","5":"Biological Replicates: BC1-ECs (n=3); C12-ECs (n=2); hiPSC-ECs (n=3). Technical triplicates were performed for each gene analyzed.","6":"[\"RT-PCR\"]","7":"[\"Human\"]","8":"[]","9":"syn21630078, syn21630079, syn21630080","10":"[\"Microenvironment\", \"Metastasis\", \"Metabolism\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349766","14":"[\"CA210173\"]","15":"Johns Hopkins Physical Sciences Oncology Center (PS-OC)","16":"syn21649154","17":"Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells","18":"[Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells (PMID:30044986)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30044986)","19":"[GEO:GSE115870](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE115870)","_rn_":"175"},{"1":"syn21811287","2":"An Optically Decodable Bead Array for Linking Imaging and Sequencing with Single-Cell Resolution","3":"PRJNA476792","4":"Optically decodable beads link the identity of an analyte or sample to a measurement through an optical barcode, enabling libraries of biomolecules to be captured on beads in solution and decoded by fluorescence. This approach has been foundational to microarray, sequencing, and flow-based expression profiling technologies. We have combined microfluidics with optically decodable beads to link phenotypic analysis of living cells to sequencing. As a proof-of-concept, we applied this to demonstrate an accurate and scalable tool for connecting live cell imaging to single-cell RNA-Seq called Single Cell Optical Phenotyping and Expression (SCOPE-Seq).","5":"Performed SCOPE-Seq on thousands of cells from two cell lines.","6":"[\"Single Cell RNA-Sequencing\", \"Imaging\"]","7":"[\"Human\", \"Mouse\"]","8":"[]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21681501","17":"SCOPE-Seq: a scalable technology for linking live cell imaging and single-cell RNA sequencing","18":"[SCOPE-Seq: a scalable technology for linking live cell imaging and single-cell RNA sequencing (PMID:30583733)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30583733)","19":"[GEO:GSE116011](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116011), [SRA:SRP150876](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP150876)","_rn_":"176"},{"1":"syn21809465","2":"Beadarray expression analysis to identify how LILRB2 blockade may affect transcriptional networks in M(LPS) and M(IL4)","3":"PRJNA481786","4":"We performed Illumina microarrays to identify how LILRB2 blockade may affect transcriptional networks in M(LPS) and M(IL4). To compare M(LPS) and M(IL4) populations helped define markers and pathway networks associated with M1 vs. M2-like functional phenotypes","5":"The expression levels of transcripts in human purified CD33 myeloid cells treated with antiLILRB2 antagonistic antibody and control Ig in the presence of IL4 or LPS. Three independent replicates from three healthy donors were analyzed for each condition.","6":"[\"Expression Array\"]","7":"[\"Human\"]","8":"[]","9":"syn21630075, syn21630077, syn21630078","10":"[\"Heterogeneity\", \"Tumor-Immune\", \"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349762","14":"[\"CA210181\"]","15":"The Center for Immunotherapeutic Transport Oncophysics","16":"syn21681441","17":"Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity","18":"[Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity (PMID:30352428)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30352428)","19":"[GEO:GSE117340](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117340)","_rn_":"177"},{"1":"syn21809454","2":"Colonic adenoma and adjacent normal single-cell RNA-seq","3":"PRJNA482649","4":"colonic adenoma and adjacent normal from Lrig1-creERT2;Apc-fl/+ mouse","5":"tumor and adjacent normal","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Colon Adenocarcinoma\"]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084053","14":"[\"CA215798\"]","15":"Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy","16":"syn21649039","17":"Quantitative assessment of cell population diversity in single-cell landscapes","18":"[Quantitative assessment of cell population diversity in single-cell landscapes (PMID:30346945)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30346945)","19":"[GEO:GSE117615](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117615)","_rn_":"178"},{"1":"syn21812500","2":"In situ 10-cell RNA sequencing in tissue and tumor biopsy samples","3":"PRJNA492323","4":"We combined the tissue preservation and single-cell resolution of laser capture with an improved preamplification procedure enabling RNA sequencing of 10 microdissected cells. This in situ 10-cell RNA sequencing (10cRNA-seq) can exploit fluorescent reporters of cell type in genetically engineered mice and is compatible with freshly cryoembedded clinical biopsies from patients. By using small pools of microdissected cells, 10cRNA-seq thus results in improved per-cell reliability and sensitivity beyond existing approaches for single-cell RNA sequencing (scRNA-seq). Accordingly, in multiple tissue and tumor settings, we observe 1.5<U+2013>2-fold increases in genes detected and overall alignment rates compared to scRNA-seq. Combined with existing approaches to deconvolve small pools of cells, 10cRNA-seq offers a reliable, unbiased, and sensitive way to measure cell-state heterogeneity in tissues and tumors.","5":"10-cell samples from various tissue sources captured by laser capture microdissection. mRNA was extracted and PCR amplified for RNA-sequencing","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Human\", \"Mouse\"]","8":"[\"Carcinoma in situ of Breast\", \"Lung Small Cell Carcinoma\"]","9":"syn21630075, syn21630081","10":"[\"Heterogeneity\", \"Evolution\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084062","14":"[\"CA215794\"]","15":"An Integrated Systems Approach for Incompletely Penetrant Onco-phenotypes","16":"syn21681604","17":"In situ 10-cell RNA sequencing in tissue and tumor biopsy samples","18":"[In situ 10-cell RNA sequencing in tissue and tumor biopsy samples (PMID:30894605)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30894605)","19":"[GEO:GSE120261](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE120261), [SRA:SRP162268](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP162268)","_rn_":"179"},{"1":"syn21809528","2":"Effect of chromatin accessibility due to loss of PIN1","3":"PRJNA495629","4":"The goal of this study was to determine the chromatin accessibility difference between WT and PIN1 knockout mouse embryonic fibroblasts.","5":"Wildtype and PIN1 knockout MEFs were serum starved for 48 hours, and stimulated 4hrs to induce MYC expression. ATAC-seq were performed on three biological replicates for each condition.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630075, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773345","14":"[\"CA209988\"]","15":"Measuring, Modeling and Controlling Heterogeneity (M2CH)","16":"syn21649183","17":"Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals","18":"[Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals (PMID:30366908)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30366908)","19":"[GEO:GSE121094](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121094), [SRA:SRP164935](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP164935)","_rn_":"180"},{"1":"syn21812579","2":"BRCA1 Mutations Attenuate Super-Enhancer Function and Chromatin Looping in Haploinsufficient Human Breast Epithelial Cells","3":"PRJNA496412","4":"BRCA1 functions in multiple biological processes, including double-strand break repair, replication stress suppression, transcriptional regulation, and chromatin reorganization. While non-malignant cells carrying cancer-predisposing BRCA1 mutations exhibit increased genomic instability, it remains unclear whether BRCA1 haploinsufficiency affects transcription and chromatin dynamics. Here we show that primary mammary epithelial cells from women with BRCA1 mutations (BRCA1mut/+) display significant loss of H3K27ac-associated super-enhancers.","5":"Primary human mammary epithelial cells (HMECs) were isolated from fresh cancer-free breast tissues of BRCA1 mutation carriers (BRCA1mut/+, n = 3) and non-carriers (BRCA1+/+, n = 3), who underwent prophylactic mastectomy and reduction mammoplasty, respectively. H3K27ac chromatin immunoprecipitation with deep-sequencing (ChIP-seq) was performed.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681667","17":"BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells","18":"[BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells (PMID:30995943)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30995943)","19":"[GEO:GSE121229](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121229), [SRA:SRP165726](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP165726)","_rn_":"181"},{"1":"syn21811019","2":"Linking single-cell measurements of mass, growth rate, and gene expression","3":"PRJNA498045","4":"We introduce a microfluidic platform that enables single-cell mass and growth rate measurements upstream of single-cell RNA-sequencing (scRNA-seq) to generate paired single-cell biophysical and transcriptional data sets. Biophysical measurements are collected with a serial suspended microchannel resonator platform (sSMR) that utilizes automated fluidic state switching to load individual cells at fixed intervals, achieving a throughput of 120 cells per hour. Each single-cell is subsequently captured downstream for linked molecular analysis using an automated collection system. From linked measurements of a murine leukemia (L1210) and pro-B cell line (FL5.12), we identify gene expression signatures that correlate significantly with cell mass and growth rate. In particular, we find that both cell lines display a cell-cycle signature that correlates with cell mass, with early and late cell-cycle signatures significantly enriched amongst genes with negative and positive correlations with mass, respectively. FL5.12 cells also show a significant correlation between single-cell growth efficiency and a G1-S transition signature, providing additional transcriptional evidence for a phenomenon previously observed through biophysical measurements alone. Importantly, the throughput and speed of our platform allows for the characterization of phenotypes in dynamic cellular systems. As a proof-of principle, we apply our system to characterize activated murine CD8+ T cells and uncover two unique features of CD8+ T cells as they become proliferative in response to activation: i) the level of coordination between cell cycle gene expression and cell mass increases, and ii) translation-related gene expression increases and shows a correlation with single-cell growth efficiency. Overall, our approach provides a new means of characterizing the transcriptional mechanisms of normal and dysfunctional cellular mass and growth rate regulation across a range of biological contexts.","5":"Single-cell RNA-Sequencing of L1210 cells, FL5.12 cells, activated T cells, and cells from a patient derived glioblastoma cell line.","6":"[]","7":"[\"Mouse\", \"Human\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773338","14":"[\"CA217377\"]","15":"Quantitative and Functional Characterization of Therapeutic Resistance in Cancer","16":"syn21649021","17":"Linking single-cell measurements of mass, growth rate, and gene expression","18":"[Linking single-cell measurements of mass, growth rate, and gene expression (PMID:30482222)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30482222)","19":"[GEO:GSE121655](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121655), [SRA:SRP166447](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP166447)","_rn_":"182"},{"1":"syn21809597","2":"Single cell sequencing of mouse syngeneic tumor models","3":"PRJNA498671","4":"Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor interactions. Targeting ligand-receptor interactions, for instance with immune check-point inhibitors, can provide significant benefit for patients. However, our knowledge of which interactions occur in a tumor and how these interactions affect outcome is still limited. We present an approach to characterize communication by ligand-receptor interactions across all cell types in a microenvironment using single-cell RNA sequencing. We apply this approach to identify and compare ligand-receptor interactions present in six syngeneic mouse tumor models. To identify interactions potentially associated with outcome, we regress interactions against phenotypic measurements of tumor growth rate. In addition, we quantify ligand-receptor interactions between T-cell subsets and their relation to immune infiltration using a publicly available human melanoma data-set. Overall, this approach provides a tool for studying cell-cell interactions, their variability across tumors, and their relationship to outcome.","5":"We used three different types of immuno-competent inbred mouse strains: BALB/c, and A/J z. All animals enrolled in our study were 6-8 weeks old female mice that were housed in vivarium under specific pathogen free conditions in cages of up to 5 animals and receiving special rodent diet (Teklad). We implanted two mice for each syngeneic model resulting in a total of 12 samples. Each mouse tumor was harvested when the tumor size reached 100 <U+2013> 200 mm3. Each sample was minced and digested with reagents from Mouse Tumor Dissociation Kit (Miltenyi) according to the manufacturer<U+2019>s instructions. Cells were resuspended at 2x105 cells/mL in PBS-0.04% BSA. Each sample was processed individually and run in technical duplicates. For each sample (except CT26 and MC-38) one replicate was enriched for CD45 positive cells. Live CD45 positive cells were sorted with BD Aria after staining with FITC-CD45 (Biolegend) and 7-AAD. Single cell suspensions of all samples were resuspended in PBS-0.04% BSA at 5x105 cells/mL and barcoded with a 10x Chromium Controller (10x Genomics). In total, this procedure resulted in 24 samples.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076","10":"[\"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn17084053","14":"[\"CA215798\"]","15":"Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy","16":"syn21681451","17":"Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics","18":"[Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics (PMID:30404002)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30404002)","19":"[GEO:GSE121861](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121861), [SRA:SRP166967](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP166967)","_rn_":"183"},{"1":"syn21792696","2":"Gene expression profiles of isogenic single-cell derived clones of BRAF-mutated SK-MEL-5 melanoma cell lines","3":"PRJNA503257","4":"We recently reported that single-cell derived isogenic subclones of SKMEL5 cells have differential initial sensitivity to BRAF-inhibitors. In order to probe differences among these subclones, we selected three subclones with unique drug responses: progressing (SK-MEL-5 SC10), stationary (SK-MEL-5 SC07), and regressing (SK-MEL-5 SC01) and performed RNASeq. This study examines differentially expressed genes (DEGs) among the subclones to identify the molecular basis for initial differences in drug sensitivity.","5":"Transcriptomics analysis between single-cell derived isogenic subclones of BRAF-mutated melanoma cell line, SK-MEL-5","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Melanoma\"]","9":"syn21630076, syn21630075","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9775651","14":"[\"CA182915\"]","15":"Phenotype Transitions in Small Cell Lung Cancer","16":"syn21649049","17":"A Nonquiescent \"Idling\" Population State in Drug-Treated, BRAF-Mutated Melanoma","18":"[A Nonquiescent \"Idling\" Population State in Drug-Treated, BRAF-Mutated Melanoma (PMID:29590606)](https://www.ncbi.nlm.nih.gov/pubmed/?term=29590606)","19":"[GEO:GSE122041](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122041), [SRA:SRP167389](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP167389)","_rn_":"184"},{"1":"syn21811595","2":"Next-gen RNA sequencing of Sleeping Beauty accelerated mouse brain tumors","3":"PRJNA503264","4":"Expression profiling by high throughput sequencing","5":"23 Tumor samples were obtained from a Sleeping Beauty forward genetic screen and sequenced using Illumina HiSeq 2000","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Malignant Neoplasm of Brain\"]","9":"syn21630078, syn21630079, syn21630077","10":"[\"Microenvironment\", \"Metastasis\", \"Tumor-Immune\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349745","14":"[\"CA210190\"]","15":"Center for Modeling Tumor Cell Migration Mechanics","16":"syn21681529","17":"Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors","18":"[Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors (PMID:30674530)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30674530)","19":"[GEO:GSE122050](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122050), [SRA:SRP167390](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP167390)","_rn_":"185"},{"1":"syn21811649","2":"An Optofluidic Real-Time Cell Sorter for Longitudinal CTC Studies in Mouse Models of Cancer","3":"PRJNA504047","4":"Circulating tumor cells (CTCs) play a fundamental role in cancer progression. However, in mice, limited blood volume and the rarity of CTCs in the bloodstream preclude longitudinal, in-depth studies of these cells using existing liquid biopsy techniques. Here, we present an optofluidic system that continuously collects fluorescently-labeled CTCs from a genetically-engineered mouse model for several hours per day over multiple days or weeks. The system is based on a microfluidic cell-sorting chip connected serially to an un-anesthetized mouse via an implanted arteriovenous shunt. Pneumatically-controlled microfluidic valves capture CTCs as they flow through the device and CTC-depleted blood is returned back to the mouse via the shunt. To demonstrate the utility of our system, we profile CTCs isolated longitudinally from animals over a four-day treatment with the BET inhibitor JQ1 using single-cell RNA-Seq (scRNA-Seq) and show that our approach eliminates potential biases driven by inter-mouse heterogeneity that can occur when CTCs are collected across different mice. The CTC isolation and sorting technology presented here provides a research tool to help reveal details of how CTCs change over time, allowing studies to credential changes in CTCs as biomarkers of drug response and facilitating future studies to understand the role of CTCs in metastasis.","5":"Single-cell RNA-Sequencing of CTCs and primary tumors from a murine model of non-small cell-lung cancer","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773338","14":"[\"CA217377\"]","15":"Quantitative and Functional Characterization of Therapeutic Resistance in Cancer","16":"syn21681530","17":"Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer","18":"[Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer (PMID:30674677)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30674677)","19":"[GEO:GSE122233](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE122233), [SRA:SRP167975](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP167975)","_rn_":"186"},{"1":"syn21813770","2":"Single-cell survey of human lymphatics unveils marked endothelial cell heterogeneity and mechanisms of homing for neutrophils","3":"PRJNA512202","4":"Lymphatic vessels form a critical component in the regulation of human health and disease. While their functional significance is increasingly being recognized, the comprehensive heterogeneity of lymphatics remains uncharacterized. Here, we report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lymph nodes (LNs) by single-cell RNA sequencing. Unbiased clustering revealed six major types of human LECs. LECs lining the sub-capsular sinus (SCS) of LNs abundantly expressed neutrophil chemoattractants, whereas LECs lining the medullary sinus (MS) expressed a C-type lectin CD209. Binding of a carbohydrate Lewis X (CD15) to CD209 mediated neutrophil binding to the MS. The neutrophil-selective homing by MS LECs may retain neutrophils in the LN medulla and allow lymph-borne pathogens to clear, preventing their spread through LNs in humans. Our study provides a comprehensive characterization of LEC heterogeneity and unveils a previously undefined role for medullary LECs in human immunity.","5":"Droplet-based single-cell RNA sequencing (scRNAseq) of human CD45- CD31+ PDPN+ cells from the axillary LNs (AXLNs) and head and neck LNs (HNLNs). ScRNAseq was performed using 10X Genomics Single Cell 3' solution, version 2 according to manufacture's instructions. Libraries were sequenced on HiSeq3000.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630077, syn21630079, syn21630078","10":"[\"Tumor-Immune\", \"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315808","14":"[\"CA209971\"]","15":"Stanford University Center for Cancer Systems Biology","16":"syn21681865","17":"Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils","18":"[Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils (PMID:31402260)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31402260)","19":"[GEO:GSE124494](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124494), [SRA:SRP175077](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP175077)","_rn_":"187"},{"1":"syn21814010","2":"Molecular determinants for enzalutamide-induced transcription in prostate cancer","3":"PRJNA514909","4":"Enzalutamide, a second-generation androgen receptor (AR) antagonist, has demonstrated clinical benefit in men with prostate cancer. However, it only provides a temporary response and modest increase in survival, indicating a rapid evolution of resistance. Previous studies suggest that enzalutamide may function as a partial transcriptional agonist, but the underlying mechanisms for enzalutamide-induced transcription remain poorly understood. Here, we show that enzalutamide stimulates expression of a novel subset of genes distinct from androgen-responsive genes. Treatment of prostate cancer cells with enzalutamide enhances recruitment of pioneer factor GATA2, AR, Mediator subunits MED1 and MED14, and RNA Pol II to regulatory elements of enzalutamide-responsive genes. Mechanistically, GATA2 functions in directing AR, Mediator and Pol II loading to enzalutamide-responsive gene loci. Importantly, the GATA2 inhibitor K7174 inhibits enzalutamide-induced transcription by decreasing binding of the GATA2/AR/Mediator/Pol II transcriptional complex, contributing to sensitization of prostate cancer cells to enzalutamide treatment. Our findings provide mechanistic insight into the future combination of GATA2 inhibitors and enzalutamide for improved AR-targeted therapy.","5":"mRNA profiles of LNCaP cells treated with vehicle, DHT and Enzalutamide were generated by deep sequencing, in duplicate, using Illumina HiSeq2500\\nmRNA profiles of LNCaP cells (sicontrol or siGATA2) treated with vehicle and Enzalutamide were generated by deep sequencing, in triplicate, using Illumina HiSeq4000","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630082","10":"[\"Drug Resistance/Sensitivity\", \"Epigenetics\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773346","14":"[\"CA217297\"]","15":"Systems Analysis of Epigenomic Architecture in Cancer Progression","16":"syn21681899","17":"Molecular determinants for enzalutamide-induced transcription in prostate cancer","18":"[Molecular determinants for enzalutamide-induced transcription in prostate cancer (PMID:31501863)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31501863)","19":"[GEO:GSE125014](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125014), [SRA:SRP178865](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP178865)","_rn_":"188"},{"1":"syn21812998","2":"Digital gene expression (DGE) based transcript profiling of CDK inhibitors","3":"PRJNA515531","4":"We compare differences in gene expression induced after 6 hours of exposure to one of three CDK4/6 inhibitors or a pan-CDK inhibitor","5":"mRNA levels for 7 breast cancer cell lines or PDX models treated with one of three CDK4/6 inhibitors (abemaciclib, palbociclib, or ribociclib) at 4 concentrations (0.1, 0.3, 1, 3 um) or the pan-CDK inhibitor alvocidib at 2 concentrations (0.1, 1 um) in triplicate.","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681801","17":"Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity","18":"[Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity (PMID:31178407)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31178407)","19":"[GEO:GSE125215](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125215)","_rn_":"189"},{"1":"syn21813759","2":"Single Cell RNA seq of Genetically Engineered Mouse Models of Pancreatic Adenocarcinoma","3":"PRJNA516878","4":"We report the scRNAseq profiles of three mouse models of pancreatic cancer: KIC, KPfC, KPC. Analyses demonstrate the existence of 2 molecular subtypes of cancer cells, 2 molecular subtypes of cancer associated fibroblasts, and 2 molecular subtypes of cancer associated macrophages.","5":"Untreated mice were sacrificed at various time points prior to scRNA library generation: normal mouse at 60 days, early KIC mouse at 40 days, late KIC mouse at 60 days, late KPfC mouse at 60 days and KPC mouse at 6 months.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Pancreatic Adenocarcinoma\"]","9":"syn21630075, syn21630077, syn21630078","10":"[\"Heterogeneity\", \"Tumor-Immune\", \"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349762","14":"[\"CA210181\"]","15":"The Center for Immunotherapeutic Transport Oncophysics","16":"syn21681851","17":"Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution","18":"[Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution (PMID:31335328)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31335328)","19":"[GEO:GSE125588](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125588), [SRA:SRP181952](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP181952)","_rn_":"190"},{"1":"syn21812727","2":"Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration","3":"PRJNA517167","4":"Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration The liver is an essential organ with compartmentalized metabolic processes and significant regenerative capabilities. Repopulation of the liver parenchyma can transpire from both main epithelial cell types, hepatocytes and biliary epithelial cells (BECs). Here, we harness high-throughput single-cell RNA sequencing (scRNA-seq) to dissect the transcriptional heterogeneity and cellular diversity of these epithelial compartments in homeostasis and injury. Our data argue against the idea of a rigidly defined liver progenitor cell in BECs, finding instead that heterogeneity in homeostatic BECs is principally distinguished by a YAP-dependent program that defines a dynamic cellular state. We report that this cellular state dynamically fluctuates between BECs and can be induced in the majority of BECs in response to environmental stimuli and injury. Functional studies demonstrate that YAP is distinctly required for BEC survival in homeostasis, uncovering a tight physiological necessity for YAP signaling in BECs compared to other tissues. YAP is also essential for hepatocyte reprogramming towards a ductal progenitor fate upon injury. Finally, our data demonstrate that this YAP-driven cellular state is highly responsive to injury by physiological exposure to bile acids (BAs) via apical sodium-bile acid transporter, and that sequestration of endogenous BAs rescues the cell loss phenotype associated with homeostatic Yap deletion. Together, our findings uncover previously undescribed molecular heterogeneity within the ductal epithelium and highlight a distinct and potent role for YAP as a protective rheostat and regenerative regulator in the mammalian liver.","5":"RNA sequencing data from single biliary epithelial cells isolated from mouse livers","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773338","14":"[\"CA217377\"]","15":"Quantitative and Functional Characterization of Therapeutic Resistance in Cancer","16":"syn21681739","17":"Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration","18":"[Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration (PMID:31080134)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31080134)","19":"[GEO:GSE125688](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125688), [SRA:SRP182724](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP182724)","_rn_":"191"},{"1":"syn21812436","2":"Plasminogen activator inhibitor 1 (PAI1) promotes actin cytoskeleton reorganization and glycolytic metabolism in triple negative breast cancer","3":"PRJNA517541","4":"We altered the expression of PAI1 in SUM159 breast cancer cell line and would like to see the effects","5":"We compared the wild-type (WT) and PAI1 transfected SUM159 breast cancer cell line","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn17083789","14":"[\"CA210152\"]","15":"Environmental Regulation of Cancer Stem Cell Plasticity in Metastasis","16":"syn21681547","17":"Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer","18":"[Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer (PMID:30718260)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30718260)","19":"[GEO:GSE125802](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE125802), [SRA:SRP182754](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP182754)","_rn_":"192"},{"1":"syn18425364","2":"Single-cell combinatorial indexing ATAC-seq of HCC1143 with MEK, PI3K, and BET inhibition","3":"PRJNA521411","4":"We performed single-cell combinatorial indexing ATAC-seq on the basal-like TNBC cell line HCC1143 under MEK, PI3K, BET and combination treatments as well as DMSO controls","5":"Cells were cultured and exposed to inhibitors or vehicle for 72 hours and processed in a single batch of sci-ATAC-seq using transposition barcodes for sample tracking to eliminate batch effects downstream","6":"[\"ATAC-Seq\"]","7":"[\"Human\"]","8":"[\"Ductal Carcinoma\"]","9":"syn21630076, syn21630075, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Heterogeneity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9773345","14":"[\"CA209988\"]","15":"Measuring, Modeling and Controlling Heterogeneity (M2CH)","16":"syn21649001","17":"Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer","18":"[Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer (PMID:30232459)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30232459)","19":"[GEO:GSE126261](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE126261)","_rn_":"193"},{"1":"syn21812613","2":"Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells","3":"PRJNA523232","4":"Stable changes in chromatin states and gene expression in cells of the immune system form the basis for their memory of infections and other challenges. We used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore the mechanisms underlying long-lasting vs. transient gene regulation in antigen-specific CD8 T cells responding to acute viral infection. Our observations provide novel insights into the mechanisms driving stable and reversible transcriptional and epigenetic memory in virus-specific CD8 T cells. These findings suggest a general mechanism for the formation of epigenetic memory in CD8 T cells and other immune and non-immune cells.","5":"The project studied the chromatin accessibility and gene transcription of CD8+ T cell in response to viral infection. 70 samples were analysed in total, including 22 ATAC-Seq, 29 RNA-Seq, 18 ChIP-Seq and 1 single cell RNA-Seq samples.","6":"[]","7":"[\"Mouse\"]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21681695","17":"Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8<U+00A0>T Cells","18":"[Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8<U+00A0>T Cells (PMID:31027997)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31027997)","19":"[GEO:GSE126770](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE126770), [SRA:SRP186300](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP186300)","_rn_":"194"},{"1":"syn21812634","2":"Highly-motile versus unsorted MDA-MB-231 breast cancer cells","3":"PRJNA527110","4":"The challenge of predicting which patients with breast cancer will develop metastases leads to the overtreatment of patients with benign disease and to the inadequate treatment of the aggressive cancers. Here, we report the development and testing of a microfluidic assay that quantifies the abundance and proliferation of migratory cells in breast-cancer specimens, for the assessment of their metastatic propensity and for the rapid screening of potential antimetastatic therapeutics. On the basis of the key roles of cell motility and proliferation in cancer metastasis, the device accurately predicts the metastatic potential of breast-cancer cell lines and of patient-derived xenografts. Compared to unsorted cancer cells, highly motile cells isolated by the device exhibited similar tumourigenic potential but markedly increased metastatic propensity in vivo. RNA sequencing of the highly motile cells revealed an enrichment of motility-related and survival-related genes. The approach might be developed into a companion assay for the prediction of metastasis in patients and for the selection of effective therapeutic regimens.","5":"RNA was isolated from samples of 1000<U+00A0>migratory or unsorted cells in triplicate","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Human\"]","8":"[\"Carcinoma in situ of Breast\"]","9":"syn21630078, syn21630079, syn21630080","10":"[\"Microenvironment\", \"Metastasis\", \"Metabolism\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349766","14":"[\"CA210173\"]","15":"Johns Hopkins Physical Sciences Oncology Center (PS-OC)","16":"syn21681723","17":"A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens","18":"[A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens (PMID:31061459)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31061459)","19":"[GEO:GSE128313](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128313), [SRA:SRP188447](https://www.ncbi.nlm.nih.gov/sra?term=SRP188447)","_rn_":"195"},{"1":"syn21813525","2":"Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals cancer-associated fibroblasts expressing MHC class II","3":"PRJNA531464","4":"This study used 10X Genomics, single-cell RNA-sequencing to examine the cell types present in the KrasLSL-G12D; Trp53LSL-R172H; Pdx1-Cre (KPC) mouse model for pancreatic ductal adenocarcinoma. The study analyzed tumors from 4 different mice. For each tumor, we performed flow sorting to isolate all viable cells, and to isolate a fibroblast-enriched population of cells for single-cell RNA-seq to determine the transcriptomes of individual cells in KPC pancreatic ductal adenocarcinoma tumors.","5":"Single-cell RNA-sequencing analysis (10X Genomics and Illumina sequencing) of the viable and fibroblast-enriched cell populations taken from 4 replicate mice of the KPC mouse model of pancreatic ductal adenocarcinoma","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Pancreatic Ductal Adenocarcinoma\"]","9":"syn21630075, syn21630076","10":"[\"Heterogeneity\", \"Drug Resistance/Sensitivity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21681814","17":"Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts","18":"[Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts (PMID:31197017)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31197017)","19":"[GEO:GSE129455](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129455), [SRA:SRP191615](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP191615)","_rn_":"196"},{"1":"syn21812940","2":"Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma (ChIP-seq)","3":"PRJNA531655","4":"BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for resistance, have not been fully defined. Here, using a combination of expression profiling, genome-scale CRISPR/Cas9-mediated loss of function and ORF/cDNA driven rescue screens, and cell-based models of spontaneous resistance, we identify bHLH/homeobox transcription factors and cell-cycle regulators as key genes mediating BETi<U+2019>s response and resistance. Cells that acquire drug tolerance exhibit a more neuronally differentiated cell-state and expression of lineage-specific bHLH/homeobox transcription factors. However, they do not terminally differentiate, maintain expression of CCND2, and continue to cycle through S-phase. Moreover, CDK4/CDK6 inhibition delays acquisition of resistance. Therefore, our data provide insights about the mechanisms underlying BETi effects and the appearance of resistance and support the therapeutic use of combined cell-cycle inhibitors with BETi in MYC-amplified medulloblastoma.","5":"Drug sensitive and drug tolerant cells were treated with 1uM JQ1 or DMSO controls","6":"[]","7":"[\"Human\"]","8":"[]","9":"syn21630076, syn21630078","10":"[\"Drug Resistance/Sensitivity\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn12051865","14":"[\"CA225088\"]","15":"Center for Cancer Systems Pharmacology","16":"syn21681783","17":"Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma","18":"[Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma (PMID:31160565)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31160565)","19":"[GEO:GSE129521](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129521), [SRA:SRP192023](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP192023)","_rn_":"197"},{"1":"syn21812565","2":"Microarray of TBK1 WT and Mutant pancreatic tumors in the KIC model","3":"PRJNA534328","4":"Analysis of gene expression changes that occur in pancreatic tumors when global TBK1 is lost.","5":"Total RNA obtained from isolated fresh pancreatic tumor tissue in KIC GEMM at 8wks of age.","6":"[\"Expression Array\"]","7":"[\"Mouse\"]","8":"[\"Pancreatic Adenocarcinoma\"]","9":"syn21630075, syn21630077, syn21630078","10":"[\"Heterogeneity\", \"Tumor-Immune\", \"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349762","14":"[\"CA210181\"]","15":"The Center for Immunotherapeutic Transport Oncophysics","16":"syn21681618","17":"Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer","18":"[Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer (PMID:30938713)](https://www.ncbi.nlm.nih.gov/pubmed/?term=30938713)","19":"[GEO:GSE130232](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE130232)","_rn_":"198"},{"1":"syn21814484","2":"Single-cell connectomic analysis of adult mammalian lungs","3":"PRJNA552370","4":"Single-cell RNA sequencing (scRNAseq) has made it possible to analyze complex organs such as the lung with unprecedented resolution. We have leveraged these techniques to identify conserved patterns of cell-cell cross-talk in adult mammalian lungs, analyzing mouse, rat, pig and human pulmonary tissues. Following clustering and histological registration, we mapped putative ligand-receptor interactions within and between cell types and assessed the significance of these interactions. Our findings demonstrate specific, stereotyped functional roles for each cell type in the distal lung which emerge as top candidates for the regulation of tissue phenotype.","5":"Single-cell RNA sequenceing data was generated from the lungs of 2 mice, 2 rats, 2 pigs, and 14 humans\\nPlease note that ther are privacy concerns with the raw reads (for the human samples, GSM4050097-GSM4050115), as they are clinical in origin. Thus, the raw data files are intended to be uploaded to dbGaP in the coming months.","6":"[]","7":"[\"Human\", \"Mouse\", \"Rat\", \"Boar\"]","8":"[]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315810","14":"[\"CA209992\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion","16":"syn21681999","17":"Single-cell connectomic analysis of adult mammalian lungs","18":"[Single-cell connectomic analysis of adult mammalian lungs (PMID:31840053)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31840053)","19":"[GEO:GSE133747](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE133747), [SRA:SRP212810](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP212810)","_rn_":"199"},{"1":"syn21813995","2":"Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control [I]","3":"PRJNA555627","4":"Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show Stag2 deletion in hematopoietic stem/progenitor cells (HSPC) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. ChIP-sequencing revealed that while Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites are unoccupied by Stag1 even in Stag2-deficient HSPCs. While concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B-cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.","5":"ChIP-sequencing of PU.1 in Stag2 wildtype and knockout cells derived from murine bone marrow and spleen","6":"[\"ChIP-Seq\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21681890","17":"Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation","18":"[Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation (PMID:31495782)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31495782)","19":"[GEO:GSE134583](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134583), [SRA:SRP215518](https://www.ncbi.nlm.nih.gov/sra?term=SRP215518)","_rn_":"200"},{"1":"syn21813982","2":"Stag1 and Stag2 regulate cell fate decisions in hematopoiesis through non-redundant topological control [II]","3":"PRJNA557111","4":"Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show Stag2 deletion in hematopoietic stem/progenitor cells (HSPC) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. ChIP-sequencing revealed that while Stag2 and Stag1 can bind the same loci, a component of Stag2 binding sites are unoccupied by Stag1 even in Stag2-deficient HSPCs. While concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to blunted HSPC commitment to the B-cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.","5":"Single-cell RNA sequencing was performed on 6 samples ( Lin-HSPC) from Stag2 KO (n=3) and WT (n=3) mice and were assayed for transcriptome-wide RNA-sequence.","6":"[\"Single Cell RNA-Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21681890","17":"Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation","18":"[Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation (PMID:31495782)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31495782)","19":"[GEO:GSE134997](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE134997), [SRA:SRP216650](https://www.ncbi.nlm.nih.gov/sra?term=SRP216650)","_rn_":"201"},{"1":"syn21814176","2":"RNA Sequencing analysis of xenografts for mouse gene expression changes","3":"PRJNA559355","4":"Control and 2G8-treated MiaPaca-2 and Colo375 xenografts were subjected to RNA-seq analysis for mouse gene expression changes","5":"Tumor tissues were harvested in RLT lysis buffer and purified according to instructions of the RNeasy Plus Kit (QIAGEN). RNA concentration was determined by a Qubit fluorometer (Thermo Fisher Scientific) and then prepared with TruSeq Stranded Total RNA Sample Prep Kit (Illumina). Samples were quantified, normalized, and sequenced on the Illumina HiSeq 2500 with at least 25 million reads per sample. FASTQ files were aligned to mouse mm10 reference transcriptome.","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[\"Pancreatic Adenocarcinoma\"]","9":"syn21630075, syn21630077, syn21630078","10":"[\"Heterogeneity\", \"Tumor-Immune\", \"Microenvironment\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349762","14":"[\"CA210181\"]","15":"The Center for Immunotherapeutic Transport Oncophysics","16":"syn21681944","17":"Targeting TGF<U+03B2>R2-mutant tumors exposes vulnerabilities to stromal TGF<U+03B2> blockade in pancreatic cancer","18":"[Targeting TGF<U+03B2>R2-mutant tumors exposes vulnerabilities to stromal TGF<U+03B2> blockade in pancreatic cancer (PMID:31609088)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31609088)","19":"[GEO:GSE135578](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135578), [SRA:SRP217843](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP217843)","_rn_":"202"},{"1":"syn21814183","2":"Evolved Labels of Placental Invasion in Human and Bovine Endometrial Stroma","3":"PRJNA562073","4":"Among mammals, the extent of placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (e.g. humans) are more vulnerable to malignancy, whereas animals with a non-invasive placenta (e.g. ruminants) are less likely to develop malignant cancer. To explain this correlation,we propose the hypothesis of Evolved Levels ofInvasibility (ELI) positing that the permissiveness of stromal tissue to invasion is a unitary character affecting both placental and cancer invasion. We provide evidence for this hypothesis by contrasting invasion of human and bovine cancer and placental cells into a lawn of stromal cells from different species. We find that both bovine endometrial andskin fibroblasts are more resistant to invasion of placental and cancer cells than their human counterparts. Gene expression profiling identified genes with high expression in human but not bovine fibroblasts. Knocking down of a subset of them in human fibroblasts leads to significantly stronger resistance to cancer cell invasion. Comparative analysis of gene expression among mammals suggests that humans evolved higher vulnerability to malignancy than the eutherian ancestor, possibly as a correlate of more invasive placentation, and boroeutherians evolved to decrease stromal invasibility. Identifying the evolutionary determinants of stromal invasibility can provide significant insights to developrational anti-metastatic therapeutics.","5":"3 samples each of human and bovine endometrial stromal trophoblasts were sequenced with and without co-culture with their respective trophoblasts","6":"[]","7":"[\"Human\", \"Cow\"]","8":"[]","9":"syn21630079, syn21630078","10":"[\"Metastasis\", \"Microenvironment\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315810","14":"[\"CA209992\"]","15":"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion","16":"syn21681987","17":"Evolution of placental invasion and cancer metastasis are causally linked","18":"[Evolution of placental invasion and cancer metastasis are causally linked (PMID:31768023)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31768023)","19":"[GEO:GSE136299](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE136299), [SRA:SRP219234](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP219234)","_rn_":"203"},{"1":"syn21813875","2":"Stag1 and Stag2 Impact Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation [ATAC_LSK_GMP_CFUE_Stag2KOWT]","3":"PRJNA574134","4":"Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. Chromatin immunoprecipitation (ChIP) sequencing revealed that, although Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites is unoccupied by Stag1, even in Stag2-deficient HSPCs. Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.","5":"ATAC-seq of Stag2 KO and WT LSK, GMP, and CFU-E cells","6":"[\"ATAC-Seq\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21681890","17":"Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation","18":"[Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation (PMID:31495782)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31495782)","19":"[GEO:GSE138003](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138003),[SRA:SRP223256](https://www.ncbi.nlm.nih.gov/sra?term=SRP223256)","_rn_":"204"},{"1":"syn21813864","2":"Stag1 and Stag2 Impact Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation [ATAC_LinNegBM]","3":"PRJNA574135","4":"Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. Chromatin immunoprecipitation (ChIP) sequencing revealed that, although Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites is unoccupied by Stag1, even in Stag2-deficient HSPCs. Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.","5":"ATAC-seq of Stag2 KO and WT lineage depleted bone marrow","6":"[\"ATAC-Seq\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21681890","17":"Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation","18":"[Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation (PMID:31495782)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31495782)","19":"[GEO:GSE138004](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138004),[SRA:SRP223257](https://www.ncbi.nlm.nih.gov/sra?term=SRP223257)","_rn_":"205"},{"1":"syn21813819","2":"Stag1 and Stag2 Impact Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation [ChIP_LinNeg_Stag1Stag2CTCF]","3":"PRJNA574136","4":"Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. Chromatin immunoprecipitation (ChIP) sequencing revealed that, although Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites is unoccupied by Stag1, even in Stag2-deficient HSPCs. Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.","5":"ChIP-sequencing of Stag1, Stag2, Smc1a, Smc3, and CTCF in Stag2 wildtype and knockout cells","6":"[\"ChIP-Seq\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21681890","17":"Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation","18":"[Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation (PMID:31495782)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31495782)","19":"[GEO:GSE138005](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138005),[SRA:SRP223263](https://www.ncbi.nlm.nih.gov/sra?term=SRP223263)","_rn_":"206"},{"1":"syn21813811","2":"Stag1 and Stag2 Impact Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation [RNA_3populations_LSK_GMP_CFUE]","3":"PRJNA574137","4":"Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. Chromatin immunoprecipitation (ChIP) sequencing revealed that, although Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites is unoccupied by Stag1, even in Stag2-deficient HSPCs. Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.","5":"RNA-seq of Stag2 KO and WT LSK, GMP, and CFU-E cells","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21681890","17":"Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation","18":"[Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation (PMID:31495782)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31495782)","19":"[GEO:GSE138006](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138006),[SRA:SRP223261](https://www.ncbi.nlm.nih.gov/sra?term=SRP223261)","_rn_":"207"},{"1":"syn21813804","2":"Stag1 and Stag2 Impact Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation [RNA_LinNegBM]","3":"PRJNA574138","4":"Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation. Chromatin immunoprecipitation (ChIP) sequencing revealed that, although Stag2 and Stag1 bind a shared set of genomic loci, a component of Stag2 binding sites is unoccupied by Stag1, even in Stag2-deficient HSPCs. Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage. Our data illustrate a role for Stag2 in transformation and transcriptional dysregulation distinct from its shared role with Stag1 in chromosomal segregation.","5":"RNA-seq of Stag2 KO and WT lineage depleted bone marrow","6":"[\"Whole Transcriptome Sequencing\"]","7":"[\"Mouse\"]","8":"[]","9":"syn21630080, syn21630075, syn21630081","10":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","11":"syn21630128","12":"[\"PS-ON\"]","13":"syn7349742","14":"[\"CA193419\"]","15":"Chicago Region Physical Science Oncology Center","16":"syn21681890","17":"Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation","18":"[Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation (PMID:31495782)](https://www.ncbi.nlm.nih.gov/pubmed/?term=31495782)","19":"[GEO:GSE138007](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138007), [SRA:SRP223262](https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP223262)","_rn_":"208"},{"1":"syn11678365","2":"Single-cell RNA-seq of Glioblastoma Tumors","3":"Glioblastoma Data","4":"NA","5":"NA","6":"[\"Single Cell Sequencing\"]","7":"[\"Human\"]","8":"[\"Glioblastoma\"]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315802","14":"[\"CA209997\"]","15":"Center for Cancer Systems Therapeutics (CaST)","16":"syn21648955","17":"Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm","18":"[Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm](https://www.ncbi.nlm.nih.gov/pubmed/?term=29662057)","19":"NA","_rn_":"209"},{"1":"syn20826574","2":"Genetic Interactions of Chromatin-Related Genes","3":"Genetic Interactions of Chromatin-Related Genes","4":"Network depicting significant negative (blue) and positive (grey) genetic interactions between chromatin related genes.","5":"NA","6":"[\"CRISPR\"]","7":"[\"Human\"]","8":"[]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn10140998","14":"[\"CA209891\"]","15":"The Cancer Cell Map Initiative","16":"syn21645343","17":"Genetic interaction mapping in mammalian cells using CRISPR interference","18":"[Genetic interaction mapping in mammalian cells using CRISPR interference](https://www.ncbi.nlm.nih.gov/pubmed/?term=28481362)","19":"NA","_rn_":"210"},{"1":"syn20826577","2":"Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions","3":"Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions","4":"We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual guide RNAs in three cell lines, comprising 141,912 tests of interaction.","5":"NA","6":"[\"CRISPR\"]","7":"[\"Human\"]","8":"[]","9":"syn21630081, syn21630075","10":"[\"Evolution\", \"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn10140998","14":"[\"CA209891\"]","15":"The Cancer Cell Map Initiative","16":"syn21645347","17":"Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions","18":"[Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions](https://www.ncbi.nlm.nih.gov/pubmed/?term=28319113)","19":"NA","_rn_":"211"},{"1":"syn21889770","2":"phs001231.v2.p1","3":"phs001231.v2.p1","4":"NA","5":"NA","6":"[\"ATAC-Seq\"]","7":"[\"Human\"]","8":"[]","9":"syn21630075","10":"[\"Heterogeneity\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn9772917, syn9772917","14":"[\"CA184898\", \"CA184898\"]","15":"Embryonal Brain Tumor Networks | Embryonal Brain Tumor Networks","16":"syn21645594","17":"Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells","18":"[Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells (PMID:27146274)](https://www.ncbi.nlm.nih.gov/pubmed/?term=27146274)","19":"[dbGaP:phs001231.v2.p1](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001231.v2.p1)","_rn_":"212"},{"1":"syn21889771","2":"phs001680.v1.p1","3":"phs001680.v1.p1","4":"NA","5":"NA","6":"[]","7":"[]","8":"[]","9":"syn21630077, syn21630078, syn21630076, syn21630079","10":"[\"Tumor-Immune\", \"Microenvironment\", \"Drug Resistance/Sensitivity\", \"Metastasis\"]","11":"syn21630127","12":"[\"CSBC\"]","13":"syn7315805","14":"[\"CA209975\"]","15":"CSBC Research Center for Cancer Systems Immunology at MSKCC","16":"syn21645338","17":"Chromatin states define tumour-specific T cell dysfunction and reprogramming","18":"[Chromatin states define tumour-specific T cell dysfunction and reprogramming (PMID:28514453)](https://www.ncbi.nlm.nih.gov/pubmed/?term=28514453)","19":"[dbGaP:phs001680.v1.p1](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001680.v1.p1)","_rn_":"213"}],"options":{"columns":{"min":{},"max":[10],"total":[19]},"rows":{"min":[10],"max":[10],"total":[213]},"pages":{}}}
</script>
</div>
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```r
```r
merged_dataset_syntable <- update_synapse_table(\syn21897968\, merged_dataset_cleaned, syn, syntab)
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## Publications
<!-- rnb-text-end -->
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<!-- rnb-source-begin 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 -->
```r
merged_publication_df %>%
select(-grantInstitution) %>%
mutate(grantId = map(grantId, json_to_list)) %>%
unnest(grantId) %>%
left_join(select(merged_grant_df, grantId, institutionId, institutionAlias, grantInstitution),
by = "grantId") %>%
# group_by_at(vars(-one_of(c("institutionId", "institutionAlias")))) %>%
# summarize_all(~ str_c(., collapse = ", ")) %>%
# ungroup() %>%
# mutate(institutionAlias = map_chr(institutionAlias, .delim_str_to_json)) %>%
I
```r
merged_publication_cleaned <- merged_publication_df %>%
mutate(grantId = map(grantId, json_to_list)) %>%
mutate(grant = map(grant, json_to_list)) %>%
unnest(cols = c(\grantId\, \grant\)) %>%
mutate(grant = ifelse(grantId == \syn9775651\, \CA215845\, grant)) %>%
group_by(publicationId) %>%
mutate_at(c(\grantId\, \grant\), ~ str_c(., collapse = \
Vectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' 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attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributesVectorizing 'json' elements may not preserve their attributes
```r
merged_publication_cleaned
<!-- rnb-source-end -->
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Adaptive Cancer Therapies","8":"2018","9":"","10":"Gallaher JA, Enriquez-Navas PM, Luddy KA, Gatenby RA, Anderson ARA","11":"[\"Mathematical Modeling\"]","12":"[\"Pan-cancer\"]","13":"[]","14":"syn21630081, syn21630076, syn21630078, syn21630077","15":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Tumor-Immune\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349753\"]","19":"[\"CA193489\"]","20":"[\"H Lee Moffitt Cancer Center and Research Institute\"]","21":"","22":"","_rn_":"981"},{"1":"syn21681858","2":"","3":"PLoS Comput Biol","4":"31356595","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=31356595","6":"[PMID:31356595](https://www.ncbi.nlm.nih.gov/pubmed/?term=31356595)","7":"Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data","8":"2019","9":"","10":"Chkhaidze K, Heide T, Werner B, Williams MJ, Huang W, Caravagna G, Graham TA, Sottoriva A","11":"[]","12":"[]","13":"[]","14":"syn21630081, syn21630075, syn21630082, syn21630078","15":"[\"Evolution\", \"Heterogeneity\", \"Epigenetics\", \"Microenvironment\"]","16":"syn21630127","17":"[\"CSBC\"]","18":"[\"syn18435688\"]","19":"[\"CA217376\"]","20":"[\"Arizona Cancer and Evolution Center\"]","21":"","22":"","_rn_":"982"},{"1":"syn21649026","2":"","3":"Proc Natl Acad Sci U S A","4":"29866846","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=29866846","6":"[PMID:29866846](https://www.ncbi.nlm.nih.gov/pubmed/?term=29866846)","7":"Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility","8":"2018","9":"Src, lipid bilayer, metastasis, microfabrication, single molecule","10":"Chen Z, Oh D, Biswas KH, Yu CH, Zaidel-Bar R, Groves JT","11":"[\"3D Cell Culture\"]","12":"[]","13":"[]","14":"syn21630075, syn21630078","15":"[\"Heterogeneity\", \"Microenvironment\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7416710\"]","19":"[\"CA202241\"]","20":"[\"ECM geometrical and mechanical properties modulate RTK signaling\"]","21":"","22":"","_rn_":"983"},{"1":"syn21649176","2":"","3":"Biophys J","4":"30075851","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=30075851","6":"[PMID:30075851](https://www.ncbi.nlm.nih.gov/pubmed/?term=30075851)","7":"Spatiomechanical Modulation of EphB4-Ephrin-B2 Signaling in Neural Stem Cell Differentiation","8":"2018","9":"","10":"Dong M, Spelke DP, Lee YK, Chung JK, Yu CH, Schaffer DV, Groves JT","11":"[]","12":"[]","13":"[]","14":"syn21630075, syn21630078","15":"[\"Heterogeneity\", \"Microenvironment\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7416710\"]","19":"[\"CA202241\"]","20":"[\"ECM geometrical and mechanical properties modulate RTK signaling\"]","21":"","22":"","_rn_":"984"},{"1":"syn21645572","2":"","3":"Nat Genet","4":"28263318","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=28263318","6":"[PMID:28263318](https://www.ncbi.nlm.nih.gov/pubmed/?term=28263318)","7":"Spatiotemporal genomic architecture informs precision oncology in glioblastoma","8":"2017","9":"","10":"Lee JK, Wang J, Sa JK, Ladewig E, Lee HO, Lee IH, Kang HJ, Rosenbloom DS, Camara PG, Liu Z, van Nieuwenhuizen P, Jung SW, Choi SW, Kim J, Chen A, Kim KT, Shin S, Seo YJ, Oh JM, Shin YJ, Park CK, Kong DS, Seol HJ, Blumberg A, Lee JI, Iavarone A, Park WY, Rabadan R, Nam DH","11":"[\"Whole Transcriptome Sequencing\", \"Whole Exome Sequencing\"]","12":"[\"Glioblastoma\"]","13":"[\"Brain\"]","14":"syn21630075, syn21630081, syn21630079","15":"[\"Heterogeneity\", \"Evolution\", \"Metastasis\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349759\"]","19":"[\"CA193313\"]","20":"[\"Columbia University Center for Topology of Cancer Evolution and Heterogeneity\"]","21":"","22":"","_rn_":"985"},{"1":"syn21648948","2":"","3":"Lancet Oncol","4":"29753700","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=29753700","6":"[PMID:29753700](https://www.ncbi.nlm.nih.gov/pubmed/?term=29753700)","7":"Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort","8":"2018","9":"","10":"Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugi`eres L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hern'aiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Sch\"uz J, Johansen C, Andersen TV, R\"o\"osli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon DA, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM","11":"[\"Whole Genome Sequencing\", \"Whole Exome Sequencing\"]","12":"[\"Tumor of Cerebellum\"]","13":"[\"Brain\"]","14":"syn21630075","15":"[\"Heterogeneity\"]","16":"syn21630127","17":"[\"CSBC\"]","18":"[\"syn9772917\"]","19":"[\"CA184898\"]","20":"[\"Embryonal Brain Tumor Networks\"]","21":"","22":"","_rn_":"986"},{"1":"syn21681475","2":"","3":"Proc Natl Acad Sci U S A","4":"30504144","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=30504144","6":"[PMID:30504144](https://www.ncbi.nlm.nih.gov/pubmed/?term=30504144)","7":"Spontaneous migration of cellular aggregates from giant keratocytes to running spheroids","8":"2018","9":"bipedal stick–slip motion, cell aggregate, collective migration, dewetting, reactive wetting","10":"Beaune G, Blanch-Mercader C, Douezan S, Dumond J, Gonzalez-Rodriguez D, Cuvelier D, Ondarcuhu T, Sens P, Dufour S, Murrell MP, Brochard-Wyart F","11":"[]","12":"[]","13":"[]","14":"syn21630079, syn21630078","15":"[\"Metastasis\", \"Microenvironment\"]","16":"syn21630127","17":"[\"CSBC\"]","18":"[\"syn7315810\"]","19":"[\"CA209992\"]","20":"[\"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion\"]","21":"","22":"","_rn_":"987"},{"1":"syn21648942","2":"","3":"Leuk Lymphoma","4":"29569971","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=29569971","6":"[PMID:29569971](https://www.ncbi.nlm.nih.gov/pubmed/?term=29569971)","7":"Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells","8":"2018","9":"Retinoic acid, SFK inhibitors, leukemia","10":"MacDonald RJ, Bunaciu RP, Ip V, Dai D, Tran D, Varner JD, Yen A","11":"[\"Expression Array\"]","12":"[\"Acute Promyelolitic Leukemia\"]","13":"[\"Blood\"]","14":"syn21630080, syn21630078, syn21630079","15":"[\"Metabolism\", \"Microenvironment\", \"Metastasis\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349770\"]","19":"[\"CA210184\"]","20":"[\"Center on the Physics of Cancer Metabolism\"]","21":"","22":"","_rn_":"988"},{"1":"syn21681533","2":"","3":"Biotechnol Bioeng","4":"30684357","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=30684357","6":"[PMID:30684357](https://www.ncbi.nlm.nih.gov/pubmed/?term=30684357)","7":"Stable recombinant production of codon-scrambled lubricin and mucin in human cells","8":"2019","9":"Muc1, PRG4, bioprocess, custom gene synthesis, lubrication, lubricin, mucin, recombinant, synthetic biology, tribology","10":"Shurer CR, Wang Y, Feeney E, Head SE, Zhang VX, Su J, Cheng Z, Stark MA, Bonassar LJ, Reesink HL, Paszek MJ","11":"[]","12":"[]","13":"[]","14":"syn21630080, syn21630078, syn21630079","15":"[\"Metabolism\", \"Microenvironment\", \"Metastasis\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349770\"]","19":"[\"CA210184\"]","20":"[\"Center on the Physics of Cancer Metabolism\"]","21":"","22":"","_rn_":"989"},{"1":"syn21648996","2":"","3":"IEEE Trans Control Netw Syst","4":"30320141","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=30320141","6":"[PMID:30320141](https://www.ncbi.nlm.nih.gov/pubmed/?term=30320141)","7":"State observation and sensor selection for nonlinear networks","8":"2018","9":"complex networks, observability, sensor selection, state and parameter estimation","10":"Haber A, Molnar F, Motter AE","11":"[\"Mathematical Modeling\"]","12":"[]","13":"[]","14":"syn21630080, syn21630075, syn21630081","15":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349742\"]","19":"[\"CA193419\"]","20":"[\"Chicago Region Physical Science Oncology Center\"]","21":"","22":"","_rn_":"990"},{"1":"syn21645451","2":"","3":"Physiology (Bethesda)","4":"29212889","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=29212889","6":"[PMID:29212889](https://www.ncbi.nlm.nih.gov/pubmed/?term=29212889)","7":"Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics","8":"2018","9":"","10":"Smith LR, Cho S, Discher DE","11":"[\"Hydrogels\"]","12":"[]","13":"[]","14":"syn21630078, syn21630081, syn21630079","15":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349747\"]","19":"[\"CA193417\"]","20":"[\"Physical Science Oncology Center at Penn\"]","21":"","22":"","_rn_":"991"},{"1":"syn21645363","2":"","3":"IEEE Trans Biomed Eng","4":"28113244","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=28113244","6":"[PMID:28113244](https://www.ncbi.nlm.nih.gov/pubmed/?term=28113244)","7":"Stem Cell Plasticity and Niche Dynamics in Cancer Progression","8":"2017","9":"","10":"Picco N, Gatenby RA, Anderson ARA","11":"[\"Mathematical Modeling\"]","12":"[\"Carcinoma in situ of Breast\"]","13":"[\"Breast\"]","14":"syn21630081, syn21630076, syn21630078, syn21630077","15":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Tumor-Immune\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349753\"]","19":"[\"CA193489\"]","20":"[\"H Lee Moffitt Cancer Center and Research Institute\"]","21":"","22":"","_rn_":"992"},{"1":"syn21645419","2":"","3":"Opt Express","4":"28380910","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=28380910","6":"[PMID:28380910](https://www.ncbi.nlm.nih.gov/pubmed/?term=28380910)","7":"Stochastic fluorescence switching of nucleic acids under visible light illumination","8":"2017","9":"","10":"Dong B, Almassalha LM, Soetikno BT, Chandler JE, Nguyen TQ, Urban BE, Sun C, Zhang HF, Backman V","11":"[\"Microscopy\", \"Mass Spectrometry\"]","12":"[]","13":"[]","14":"syn21630080, syn21630075, syn21630081","15":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349742\"]","19":"[\"CA193419\"]","20":"[\"Chicago Region Physical Science Oncology Center\"]","21":"","22":"","_rn_":"993"},{"1":"syn21681830","2":"","3":"Proc Natl Acad Sci U S A","4":"31278151","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=31278151","6":"[PMID:31278151](https://www.ncbi.nlm.nih.gov/pubmed/?term=31278151)","7":"Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction","8":"2019","9":"bistability, kinase, phosphatase, polarization, stochastic","10":"Hansen SD, Huang WYC, Lee YK, Bieling P, Christensen SM, Groves JT","11":"[]","12":"[]","13":"[]","14":"syn21630075, syn21630078","15":"[\"Heterogeneity\", \"Microenvironment\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7416710\"]","19":"[\"CA202241\"]","20":"[\"ECM geometrical and mechanical properties modulate RTK signaling\"]","21":"","22":"","_rn_":"994"},{"1":"syn21645350","2":"","3":"Genetics","4":"27770034","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=27770034","6":"[PMID:27770034](https://www.ncbi.nlm.nih.gov/pubmed/?term=27770034)","7":"Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging","8":"2016","9":"bacterial persistence, bet-hedging, drug resistance, evolution, genotype–phenotype map","10":"Nichol D, Robertson-Tessi M, Jeavons P, Anderson AR","11":"[\"Mathematical Modeling\"]","12":"[]","13":"[]","14":"syn21630081, syn21630076, syn21630078, syn21630077","15":"[\"Evolution\", \"Drug Resistance/Sensitivity\", \"Microenvironment\", \"Tumor-Immune\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349753\"]","19":"[\"CA193489\"]","20":"[\"H Lee Moffitt Cancer Center and Research Institute\"]","21":"","22":"","_rn_":"995"},{"1":"syn21645399","2":"","3":"Nat Commun","4":"29416042","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=29416042","6":"[PMID:29416042](https://www.ncbi.nlm.nih.gov/pubmed/?term=29416042)","7":"Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries","8":"2018","9":"","10":"Gong Y, Lazaris C, Sakellaropoulos T, Lozano A, Kambadur P, Ntziachristos P, Aifantis I, Tsirigos A","11":"[\"Molecular Simulations\"]","12":"[]","13":"[]","14":"syn21630080, syn21630075, syn21630081","15":"[\"Metabolism\", \"Heterogeneity\", \"Evolution\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349742\"]","19":"[\"CA193419\"]","20":"[\"Chicago Region Physical Science Oncology Center\"]","21":"","22":"","_rn_":"996"},{"1":"syn21681612","2":"","3":"Bioessays","4":"30919472","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=30919472","6":"[PMID:30919472](https://www.ncbi.nlm.nih.gov/pubmed/?term=30919472)","7":"Stress-Induced Evolutionary Innovation: A Mechanism for the Origin of Cell Types","8":"2019","9":"cell type origin, evolutionary innovation, novelty, plasticity, stress response","10":"Wagner GP, Erkenbrack EM, Love AC","11":"[]","12":"[]","13":"[]","14":"syn21630079, syn21630078","15":"[\"Metastasis\", \"Microenvironment\"]","16":"syn21630127","17":"[\"CSBC\"]","18":"[\"syn7315810\"]","19":"[\"CA209992\"]","20":"[\"Systems Analysis of Phenotypic Switch in Control of Cancer Invasion\"]","21":"","22":"","_rn_":"997"},{"1":"syn21681772","2":"","3":"Cell","4":"31155233","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=31155233","6":"[PMID:31155233](https://www.ncbi.nlm.nih.gov/pubmed/?term=31155233)","7":"Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer","8":"2019","9":"mass spectrometry, pancreatic cancer, pancreatic ductal adenocarcinoma, single cell RNA-sequencing, single cell spatial analysis, stromal microenvironment, tumor architecture","10":"Ligorio M, Sil S, Malagon-Lopez J, Nieman LT, Misale S, Di Pilato M, Ebright RY, Karabacak MN, Kulkarni AS, Liu A, Vincent Jordan N, Franses JW, Philipp J, Kreuzer J, Desai N, Arora KS, Rajurkar M, Horwitz E, Neyaz A, Tai E, Magnus NKC, Vo KD, Yashaswini CN, Marangoni F, Boukhali M, Fatherree JP, Damon LJ, Xega K, Desai R, Choz M, Bersani F, Langenbucher A, Thapar V, Morris R, Wellner UF, Schilling O, Lawrence MS, Liss AS, Rivera MN, Deshpande V, Benes CH, Maheswaran S, Haber DA, Fernandez-Del-Castillo C, Ferrone CR, Haas W, Aryee MJ, Ting DT","11":"[]","12":"[]","13":"[]","14":"syn21630076","15":"[\"Drug Resistance/Sensitivity\"]","16":"syn21630127","17":"[\"CSBC\"]","18":"[\"syn17084053\"]","19":"[\"CA215798\"]","20":"[\"Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy\"]","21":"syn21812746","22":"PRJNA464359","_rn_":"998"},{"1":"syn21681603","2":"","3":"Proc Natl Acad Sci U S A","4":"30894480","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=30894480","6":"[PMID:30894480](https://www.ncbi.nlm.nih.gov/pubmed/?term=30894480)","7":"Strong triaxial coupling and anomalous Poisson effect in collagen networks","8":"2019","9":"3D cell traction force microscopy, fibrous matrices, matrix realignment, tissue swelling","10":"Ban E, Wang H, Franklin JM, Liphardt JT, Janmey PA, Shenoy VB","11":"[]","12":"[\"Acinar Cell Carcinoma\"]","13":"[\"Epithelium\"]","14":"syn21630078, syn21630079, syn21630081","15":"[\"Microenvironment\", \"Metastasis\", \"Evolution\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7416707\",\"syn7349747\"]","19":"[\"CA202177\",\"CA193417\"]","20":"[\"Quantitative analyses of tumor cell extravasation\", \"Physical Science Oncology Center at Penn\"]","21":"","22":"","_rn_":"999"},{"1":"syn21681330","2":"","3":"Nature","4":"29342135","5":"https://www.ncbi.nlm.nih.gov/pubmed/?term=29342135","6":"[PMID:29342135](https://www.ncbi.nlm.nih.gov/pubmed/?term=29342135)","7":"Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling","8":"2018","9":"","10":"Lee S, Choi J, Mohanty J, Sousa LP, Tome F, Pardon E, Steyaert J, Lemmon MA, Lax I, Schlessinger J","11":"[]","12":"[]","13":"[]","14":"syn21630078, syn21630081, syn21630079","15":"[\"Microenvironment\", \"Evolution\", \"Metastasis\"]","16":"syn21630128","17":"[\"PS-ON\"]","18":"[\"syn7349747\"]","19":"[\"CA193417\"]","20":"[\"Physical Science Oncology Center at Penn\"]","21":"","22":"","_rn_":"1000"}],"options":{"columns":{"min":{},"max":[10],"total":[22]},"rows":{"min":[10],"max":[10],"total":[1170]},"pages":{}}}
</script>
</div>
<!-- rnb-frame-end -->
<!-- rnb-chunk-end -->
<!-- rnb-text-begin -->
<!-- rnb-text-end -->
<!-- rnb-chunk-begin -->
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```r
merged_publication_syntable <- update_synapse_table("syn21868591", merged_publication_cleaned, syn, syntab)
---
title: "Portal Cleanup"
output: html_notebook
---

```{r}
library(reticulate)
library(dccvalidator)
library(tidyverse)
library(purrrogress)

# source("../R/synapse_db.R")

use_condaenv("csbc-pson-dcc", required = TRUE)
synapseclient <- reticulate::import("synapseclient")
syn <- synapseclient$Synapse()
syntab <- reticulate::import("synapseclient.table")
synfile <- synapseclient$File
syn$login()
```


```{r}
tibble(id = c("ICBP", "TEC")) %>% 
  create_entities("syn21630050", syn, synfile)

```

## Grants

```{r}
merged_grant_df <- dccvalidator::get_synapse_table("syn21918972", syn)
```

```{r}
db_institution_df <- dccvalidator::get_synapse_table("syn21905891", syn)
```

```{r}
merged_grant_df %>%
  select(-institutionAlias) %>% 
  # select(grantId, institutionId) %>% 
  separate_rows(institutionId, sep = ",") %>% 
  mutate_all(~ str_trim(.)) %>% 
  left_join(select(db_institution_df, institutionId = id, institutionAlias = displayName),
            by = "institutionId") %>%
  group_by_at(vars(-one_of(c("institutionId", "institutionAlias")))) %>%
  summarize_all(~ str_c(., collapse = ", ")) %>%
  ungroup() %>%
  mutate(institutionAlias = map_chr(institutionAlias, .delim_str_to_json)) %>%
  update_synapse_table("syn21918972", ., syn, syntab)
```


```{r}
merged_grant_df %>% 
  select(grantId, institutionId) %>% 
  separate_rows(institutionId, sep = ",") %>% 
  mutate_all(str_trim) %>% 
  distinct() %>% 
  I %>% 
  update_synapse_table("syn21905912", ., syn, syntab)
```

```{r}
db_institution_df <- dccvalidator::get_synapse_table("syn21905891", syn)
```

```{r}
merged_grant_cleaned <- merged_grant_df %>% 
  separate_rows(institutionId, institution, sep = "\\|") %>% 
  mutate_all(str_trim) %>% 
  distinct() %>% 
  arrange(institution) %>% 
  mutate(institutionId = case_when(
    institution == "University of Pennsylvania" ~ "syn21905883",
    institution == "University of Virginia" ~ "syn21905886",
    institution == "University of Colorado Denver" ~ "",
    institution == "University of Delaware" ~ "",
    institution == "Pacific Northwest National Laboratory" ~ "",
    institution == "Massachusetts Institute of Technology" ~ "syn21905863",
    institution == "The Hebrew University of Jerusalem" ~ "",
    TRUE ~ institutionId
  )) %>% 
  mutate(institution = str_replace(institution, "^The ", "")) %>% 
  # filter(institutionId == "") %>% 
  left_join(select(db_institution_df, id, institution = fullName), by = "institution") %>%
  mutate(institutionId = ifelse(institutionId == "", id, institutionId)) %>%
  select(-id) %>%
  distinct() %>% 
  group_by_at(vars(-contains("institution"))) %>%
  summarize(
    institutionId = str_c(unique(institutionId), collapse = ", "),
    institution = str_c(unique(institution), collapse = " | ")
  ) %>% 
  ungroup() %>% 
  mutate_all(~ ifelse(str_detect(., "Not Applicable"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '"Not Applicable"'), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., "^NA$"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '\\["NA"\\]'), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '"NA"'), NA, .)) %>%
  I
merged_grant_cleaned
```


```{r}
merged_grant_syntable <- update_synapse_table("syn21918972", merged_grant_cleaned, syn, syntab)
```


## Projects

```{r}
merged_project_df <- dccvalidator::get_synapse_table("syn21868602", syn)
```

```{r}
merged_project_cleaned <- merged_project_df %>% 
  mutate(theme = str_replace(theme, "Tumor Evolution", "Evolution")) %>% 
  mutate(theme = str_replace(theme, "metastasis", "Metastasis")) %>% 
  mutate(theme = str_replace(theme, "drug resistance/sensitivity", "Drug Resistance/Sensitivity")) %>% 
  mutate(theme = str_replace(theme, "microenvironment", "Microenvironment")) %>% 
  mutate_all(~ ifelse(str_detect(., "Not Applicable"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '"Not Applicable"'), "", .)) %>%
  mutate_all(~ ifelse(str_detect(., "^NA$"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '\\["NA"\\]'), "[]", .)) %>%
  mutate_all(~ ifelse(str_detect(., '"NA"'), "", .)) %>%
  # filter(projectId == "syn21645193") %>% 
  # update_synapse_table("syn21930566", ., syn, syntab) %>%
  I
 
merged_project_cleaned
```

```{r}
merged_project_syntable <- update_synapse_table("syn21868602", merged_project_cleaned, syn, syntab)
```

## Tools

```{r}
merged_tool_df <- dccvalidator::get_synapse_table("syn21930566", syn)
```

```{r}
merged_tool_cleaned <- merged_tool_df %>% 
  mutate(theme = str_replace(theme, "Tumor Evolution", "Evolution")) %>% 
  mutate_all(~ ifelse(str_detect(., "Not Applicable"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '"Not Applicable"'), "", .)) %>%
  mutate_all(~ ifelse(str_detect(., "^NA$"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '\\["NA"\\]'), "[]", .)) %>%
  mutate_all(~ ifelse(str_detect(., '"NA"'), "", .)) %>%
  mutate(homepageUrl = ifelse(is.na(homepageUrl), "", homepageUrl)) %>% 
  mutate(toolType = ifelse(is.na(toolType), "", toolType)) %>% 
  mutate(publicationId = ifelse(is.na(publicationId), "", publicationId)) %>% 
  mutate(publicationTitle = ifelse(is.na(publicationTitle), "", publicationTitle)) %>% 
  mutate(publication = ifelse(is.na(publication), "", publication))
 
merged_tool_cleaned
```

```{r}
merged_tool_syntable <- update_synapse_table("syn21930566", merged_tool_cleaned, syn, syntab)
```

## Datasets


```{r}
merged_dataset_df <- dccvalidator::get_synapse_table("syn21897968", syn)
```

```{r}
merged_dataset_cleaned <- merged_dataset_df %>% 
  mutate(theme = str_replace(theme, "Tumor Evolution", "Evolution")) %>% 
  mutate(theme = str_replace(theme, "metastasis", "Metastasis")) %>% 
  mutate(theme = str_replace(theme, "drug resistance/sensitivity", "Drug Resistance/Sensitivity")) %>% 
  mutate(theme = str_replace(theme, "microenvironment", "Microenvironment")) %>% 
  mutate(assay = str_replace(assay, "Whoe", "Whole")) %>% 
  mutate_all(~ ifelse(str_detect(., "Not Applicable"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '"Not Applicable"'), "", .)) %>%
  mutate_all(~ ifelse(str_detect(., "^NA$"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '\\["NA"\\]'), "[]", .)) %>%
  mutate_all(~ ifelse(str_detect(., '"NA"'), "", .)) %>%
  mutate(tumorType = ifelse(is.na(tumorType), "", tumorType)) %>% 
  # filter(datasetId == "syn21645193") %>% 
  # update_synapse_table("syn21930566", ., syn, syntab) %>%
  I
 
merged_dataset_cleaned
```

```{r}
merged_dataset_syntable <- update_synapse_table("syn21897968", merged_dataset_cleaned, syn, syntab)
```

## Publications

```{r}
merged_publication_df <- dccvalidator::get_synapse_table("syn21868591", syn)
```

```{r}
merged_publication_df %>% 
  select(-grantInstitution) %>% 
  mutate(grantId = map(grantId, json_to_list)) %>% 
  unnest(grantId) %>% 
  
  left_join(select(merged_grant_df, grantId, institutionId, institutionAlias, grantInstitution),
            by = "grantId") %>%
  # group_by_at(vars(-one_of(c("institutionId", "institutionAlias")))) %>%
  # summarize_all(~ str_c(., collapse = ", ")) %>%
  # ungroup() %>%
  # mutate(institutionAlias = map_chr(institutionAlias, .delim_str_to_json)) %>% 
  I
```


```{r}
merged_publication_cleaned <- merged_publication_df %>% 
  mutate_all(~ ifelse(str_detect(., "Not Applicable"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '"Not Applicable"'), "", .)) %>%
  mutate_all(~ ifelse(str_detect(., "^NA$"), NA, .)) %>%
  mutate_all(~ ifelse(str_detect(., '\\["NA"\\]'), "[]", .)) %>%
  mutate_all(~ ifelse(str_detect(., '"NA"'), "", .)) %>%
  mutate_at(c("doi", "keywords",
              "themeId", "theme", "datasetId", "dataset"),
            ~ ifelse(is.na(.), "", .)) %>%
  # mutate(tumorType = ifelse(is.na(tumorType), "", tumorType)) %>% 
  # mutate(doi = ifelse(is.na(doi), "", doi)) %>% 
  # mutate(keywords = ifelse(is.na(keywords), "", keywords)) %>% 
  # mutate(assay = ifelse(is.na(assay), "", assay)) %>% 
  # mutate(datasetId = ifelse(is.na(datasetId), "", datasetId)) %>% 
  # mutate(dataset = ifelse(is.na(dataset), "", dataset)) %>% 
  # filter(publicationId == "syn21645193") %>% 
  # update_synapse_table("syn21930566", ., syn, syntab) %>%
  I
 
merged_publication_cleaned
```

```{r}
merged_publication_syntable <- update_synapse_table("syn21868591", merged_publication_cleaned, syn, syntab)
```
